CuGenDBv2

Gene ID	Spg000505
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	DNA replication ATP-dependent helicase/nuclease DNA2
Genome location	scaffold8:44059490..44059865
RNA-Seq Expression	Spg000505
Synteny	Spg000505
Gene Ontology terms	GO:0006281 - DNA repair (biological process) GO:0030245 - cellulose catabolic process (biological process) GO:0032508 - DNA duplex unwinding (biological process) GO:0033567 - DNA replication, Okazaki fragment processing (biological process) GO:0071932 - replication fork reversal (biological process) GO:0005634 - nucleus (cellular component) GO:0005737 - cytoplasm (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003723 - RNA binding (molecular function) GO:0005524 - ATP binding (molecular function) GO:0008810 - cellulase activity (molecular function) GO:0016887 - ATPase activity (molecular function) GO:0017108 - 5'-flap endonuclease activity (molecular function) GO:0017116 - single-stranded DNA helicase activity (molecular function) GO:0046872 - metal ion binding (molecular function)
InterPro domains	IPR014808 - DNA replication factor Dna2, N-terminal

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7018906.1 DNA replication ATP-dependent helicase/nuclease DNA2, partial [Cucurbita argyrosperma subsp. argyrosperma]

2.0e-30

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

XP_022924798.1 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1 [Cucurbita moschata]

2.0e-30

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

XP_022924803.1 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X2 [Cucurbita moschata]

2.0e-30

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

XP_022924804.1 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X3 [Cucurbita moschata]

2.0e-30

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

XP_022924805.1 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4 [Cucurbita moschata]

2.0e-30

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L7S1 Uncharacterized protein

1.6e-30

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+D DNNFVIL  DILVSGTRVAGHLTC RR VLDERLKSNEQS++ LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

A0A6J1EA85 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X3

9.7e-31

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

A0A6J1EDH9 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X1

9.7e-31

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

A0A6J1EDI4 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X2

9.7e-31

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

A0A6J1EG37 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X4

9.7e-31

87.18

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        FDSIIAPGDTVNVI EFDDQGRCH+DHD NFVIL  D+LVSGTRVAGHLTC RR VLDERL+SNEQSIS LIGTLLHQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

SwissProt top hits

e value

%identity

Alignment

A0A1P8ASY1 DNA replication ATP-dependent helicase/nuclease JHS1

4.8e-19

56.41

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        F S ++PGD++NVI EFD  G+C +D  NNF+I+  D LV+GTRVA    C RR VLDERL+SNE +   L+GTL HQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

E1BMP7 DNA replication ATP-dependent helicase/nuclease DNA2

2.1e-06

36.25

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Query:  IAPGDTVNVIDEFDDQGRC-----HIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISE-LIGTLLHQ
        + PGD +++      +G C      ID D  ++IL  D+L+SGT +A  + C RR VL E  +S++ +  + LIGT+LH+
Subjt:  IAPGDTVNVIDEFDDQGRC-----HIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISE-LIGTLLHQ

F6QXW0 DNA replication ATP-dependent helicase/nuclease DNA2

4.7e-06

37.84

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Query:  IAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLK-SNEQSISELIGTLLH
        I PGD +++           I  D  ++IL  D+L+SGT +A  + C RR VL E+ K  ++ S   LIGT+LH
Subjt:  IAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLK-SNEQSISELIGTLLH

P51530 DNA replication ATP-dependent helicase/nuclease DNA2

2.1e-06

36.25

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Query:  IAPGDTVNVIDEFDDQGRCH-----IDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISE-LIGTLLHQ
        + PGD +++      +G C      ID D  ++IL  D+L+SGT +A  + C RR VL E  +S++ +  + LIGT+LH+
Subjt:  IAPGDTVNVIDEFDDQGRCH-----IDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISE-LIGTLLHQ

Q8QHA5 DNA replication ATP-dependent helicase/nuclease DNA2

3.6e-06

33.75

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Query:  IAPGDTVNVIDEFDDQGRCHIDH------DNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELI-GTLLH
        I PGD +++      +G C +D+      D  ++IL  D+L+SGT +A  + C RR VL E+ K  ++   +++ GT+LH
Subjt:  IAPGDTVNVIDEFDDQGRCHIDH------DNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELI-GTLLH

Arabidopsis top hits

e value

%identity

Alignment

AT1G08840.1 DNA replication helicase, putative

3.4e-20

56.41

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        F S ++PGD++NVI EFD  G+C +D  NNF+I+  D LV+GTRVA    C RR VLDERL+SNE +   L+GTL HQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

AT1G08840.2 DNA replication helicase, putative

3.4e-20

56.41

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Query:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ
        F S ++PGD++NVI EFD  G+C +D  NNF+I+  D LV+GTRVA    C RR VLDERL+SNE +   L+GTL HQ
Subjt:  FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

Sequences

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CDS sequence

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TTTGACAGTATTATTGCACCCGGAGATACTGTGAATGTTATTGATGAATTTGATGACCAAGGAAGATGTCACATTGACCACGACAATAATTTTGTTATCCTACCCCTCGA
TATACTTGTCTCTGGAACTCGGGTTGCTGGTCATTTGACTTGTCGAAGGAGGGGTGTTCTTGATGAGAGGTTGAAAAGTAACGAACAATCAATTTCAGAGTTAATTGGTA
CATTGCTGCATCAG

mRNA sequence

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Protein sequence

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FDSIIAPGDTVNVIDEFDDQGRCHIDHDNNFVILPLDILVSGTRVAGHLTCRRRGVLDERLKSNEQSISELIGTLLHQ

Spg000505 (gene) of Sponge gourd (cylindrica) v1 genome