CuGenDBv2

Gene ID	Spg001267
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	DNA repair protein RAD50
Genome location	scaffold8:44051267..44056497
RNA-Seq Expression	Spg001267
Synteny	Spg001267
Gene Ontology terms	GO:0000722 - telomere maintenance via recombination (biological process) GO:0090305 - nucleic acid phosphodiester bond hydrolysis (biological process) GO:0006302 - double-strand break repair (biological process) GO:0007004 - telomere maintenance via telomerase (biological process) GO:0016233 - telomere capping (biological process) GO:0070192 - chromosome organization involved in meiotic cell cycle (biological process) GO:0032508 - DNA duplex unwinding (biological process) GO:0000794 - condensed nuclear chromosome (cellular component) GO:0005737 - cytoplasm (cellular component) GO:0030870 - Mre11 complex (cellular component) GO:0043047 - single-stranded telomeric DNA binding (molecular function) GO:0046872 - metal ion binding (molecular function) GO:0051880 - G-quadruplex DNA binding (molecular function) GO:0016887 - ATPase activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0003691 - double-stranded telomeric DNA binding (molecular function)
InterPro domains	IPR027417 - P-loop containing nucleoside triphosphate hydrolase

Homology

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GenBank top hits

e value

%identity

Alignment

KAA0049132.1 DNA repair protein RAD50 [Cucumis melo var. makuwa]

1.1e-47

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

XP_004133980.1 DNA repair protein RAD50 isoform X1 [Cucumis sativus]

1.1e-47

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

XP_008438322.1 PREDICTED: DNA repair protein RAD50 [Cucumis melo]

1.1e-47

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

XP_022146955.1 DNA repair protein RAD50 [Momordica charantia]

1.2e-49

83.33

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Query:  IDKYQIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVR
        +   QIRWHTLREEKVKAANTLRDV+KAEEELDRLTEEK ++ L  +   HLAEA+VPL+KEKDKLLND+NELK+KLNREYEEL EKKRNFQQEVETL+R
Subjt:  IDKYQIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVR

Query:  SASKIKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        +ASKIKEYLDLK GERLKELQEKKAQAESQLQSCDIRK
Subjt:  SASKIKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

XP_031738582.1 DNA repair protein RAD50 isoform X2 [Cucumis sativus]

1.1e-47

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

TrEMBL top hits

e value

%identity

Alignment

A0A0A0L416 Zinc-hook domain-containing protein

5.3e-48

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

A0A1S3AWR7 DNA repair protein RAD50

5.3e-48

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

A0A5A7U014 DNA repair protein RAD50

5.3e-48

83.58

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

A0A5D3D3I4 DNA repair protein RAD50

5.3e-48

83.58

Show/hide

Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEK ++ L  +   HLAEAL+PL+KEKDKLLND+NELKDKLNREYEEL +KKR FQQEVETL+R+ SK
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        IKEYLDLK GERLKELQEKKAQAESQLQ CD RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

A0A6J1CYT2 DNA repair protein RAD50

5.6e-50

83.33

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Query:  IDKYQIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVR
        +   QIRWHTLREEKVKAANTLRDV+KAEEELDRLTEEK ++ L  +   HLAEA+VPL+KEKDKLLND+NELK+KLNREYEEL EKKRNFQQEVETL+R
Subjt:  IDKYQIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVR

Query:  SASKIKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        +ASKIKEYLDLK GERLKELQEKKAQAESQLQSCDIRK
Subjt:  SASKIKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

SwissProt top hits

e value

%identity

Alignment

A0A1P8ASY1 DNA replication ATP-dependent helicase/nuclease JHS1

1.4e-16

86.27

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Query:  MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ
        +FASTFVL G HYQLPPLVQSTEARENG GISLF RLSEAHPQAIS LQ+Q
Subjt:  MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ

Q9SL02 DNA repair protein RAD50

5.5e-34

60.45

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        Q RWH +REEK KAAN LRDV KAEE+L+RL EEK +L L    +++L EAL PL+KEK++LL+D+N++K + N+EYEEL+EKKRN+QQEVE L++++ K
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        I EY DLK GERL ++QEK+  ++SQLQSC+ RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

Q9URU2 DNA replication ATP-dependent helicase/nuclease dna2

1.7e-06

51.02

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Query:  ASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ
        A  FVL G HYQLPPLV+++   ++G  +SLF  LSE HP+A++ L+ Q
Subjt:  ASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ

Arabidopsis top hits

e value

%identity

Alignment

AT1G08840.1 DNA replication helicase, putative

9.6e-18

86.27

Show/hide

Query:  MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ
        +FASTFVL G HYQLPPLVQSTEARENG GISLF RLSEAHPQAIS LQ+Q
Subjt:  MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ

AT1G08840.2 DNA replication helicase, putative

9.6e-18

86.27

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Query:  MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ
        +FASTFVL G HYQLPPLVQSTEARENG GISLF RLSEAHPQAIS LQ+Q
Subjt:  MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQ

AT2G31970.1 DNA repair-recombination protein (RAD50)

3.9e-35

60.45

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Query:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK
        Q RWH +REEK KAAN LRDV KAEE+L+RL EEK +L L    +++L EAL PL+KEK++LL+D+N++K + N+EYEEL+EKKRN+QQEVE L++++ K
Subjt:  QIRWHTLREEKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASK

Query:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK
        I EY DLK GERL ++QEK+  ++SQLQSC+ RK
Subjt:  IKEYLDLKNGERLKELQEKKAQAESQLQSCDIRK

Sequences

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CDS sequence

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ATGTTTGCTTCAACATTCGTCCTTTTTGGTTATCACTATCAACTTCCTCCTCTTGTTCAGAGTACCGAGGCTCGAGAAAATGGACCGGGGATAAGCTTGTTTTGTAGGCT
TTCAGAAGCACATCCTCAAGCAATTTCCGCATTACAAAGCCAGCTAGCATATTATCAGAGGTCACGTAGGGATTGCTTGATGGTGGGATCAAAGGGAATGACGTTGGCAT
TATCACTCTGTATAACTCCCGGGAGCATAATTCGTCTAGCTATCAAGATAGCCGCTGTGGAGATACATACCATTGACAAATACCAGATAAGGTGGCACACTCTAAGAGAG
GAAAAAGTGAAAGCAGCTAATACTTTGCGTGATGTTAGGAAGGCAGAAGAAGAGTTGGATCGTCTGACTGAAGAAAAAGTCAAGTTGATTTTGATGAGAAGGAGACTGGA
GCATTTGGCAGAAGCCCTTGTCCCTTTGGCAAAGGAGAAAGATAAATTACTTAACGACCATAATGAACTCAAAGATAAACTTAATCGTGAATATGAGGAGCTGAGTGAGA
AAAAGAGGAATTTTCAGCAGGAAGTTGAGACACTTGTTAGATCAGCTTCTAAGATTAAAGAGTATCTTGATTTAAAGAATGGTGAGAGGCTGAAAGAATTACAGGAAAAG
AAAGCACAGGCAGAATCTCAACTTCAAAGTTGTGACATTAGGAAGTAG

mRNA sequence

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Protein sequence

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MFASTFVLFGYHYQLPPLVQSTEARENGPGISLFCRLSEAHPQAISALQSQLAYYQRSRRDCLMVGSKGMTLALSLCITPGSIIRLAIKIAAVEIHTIDKYQIRWHTLRE
EKVKAANTLRDVRKAEEELDRLTEEKVKLILMRRRLEHLAEALVPLAKEKDKLLNDHNELKDKLNREYEELSEKKRNFQQEVETLVRSASKIKEYLDLKNGERLKELQEK
KAQAESQLQSCDIRK

Spg001267 (gene) of Sponge gourd (cylindrica) v1 genome