; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

Spg005014 (gene) of Sponge gourd (cylindrica) v1 genome

Gene IDSpg005014
OrganismLuffa cylindrica (Sponge gourd (cylindrica) v1)
DescriptionRibonuclease H
Genome locationscaffold4:10690739..10694325
RNA-Seq ExpressionSpg005014
SyntenySpg005014
Gene Ontology termsGO:0006259 - DNA metabolic process (biological process)
GO:0003676 - nucleic acid binding (molecular function)
GO:0016787 - hydrolase activity (molecular function)
GO:0140640 - catalytic activity, acting on a nucleic acid (molecular function)
InterPro domainsNA


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAA0047477.1 uncharacterized protein E6C27_scaffold498G00940 [Cucumis melo var. makuwa]4.8e-1844.88Show/hide
Query:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE
        K+  +Q+++V+ GWTLVTRRK RKQ++ QKES  ++ ++ KGKS+R+N +K  R+  PI+EE+E   +P  PI LK+FFP+ F     +IV+CH    TE
Subjt:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE

Query:  DDNATSTTSEAIMNLEDLPSFNIDDLL
        +D   S   E     EDL    I+DLL
Subjt:  DDNATSTTSEAIMNLEDLPSFNIDDLL

KAA0047477.1 uncharacterized protein E6C27_scaffold498G00940 [Cucumis melo var. makuwa]1.4e-2552.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K++   R+S FDRI  S  R SVFQR+ST   +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

TYJ98225.1 uncharacterized protein E5676_scaffold180G001270 [Cucumis melo var. makuwa]1.4e-2552.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K+    R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

TYJ98225.1 uncharacterized protein E5676_scaffold180G001270 [Cucumis melo var. makuwa]4.8e-1844.88Show/hide
Query:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE
        K+  +Q+++V+ GWTLVTRRK RKQ++ QKES  ++ ++ KGKS+R+N +K  R+  PI+EE+E   +P  PI LK+FFP+ F     +IV+CH    TE
Subjt:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE

Query:  DDNATSTTSEAIMNLEDLPSFNIDDLL
        +D   S   E     EDL    I+DLL
Subjt:  DDNATSTTSEAIMNLEDLPSFNIDDLL

TYJ98225.1 uncharacterized protein E5676_scaffold180G001270 [Cucumis melo var. makuwa]1.4e-2552.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K+    R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

TYK18071.1 uncharacterized protein E5676_scaffold306G004020 [Cucumis melo var. makuwa]1.4e-2552.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K+    R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

TYK18071.1 uncharacterized protein E5676_scaffold306G004020 [Cucumis melo var. makuwa]4.8e-1844.88Show/hide
Query:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE
        K+  +Q+++V+ GWTLVTRRK RKQ++ QKES  ++ ++ KGKS+R+N +K  R+  PI+EE+E   +P  PI LK+FFP+ F     +IV+CH    TE
Subjt:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE

Query:  DDNATSTTSEAIMNLEDLPSFNIDDLL
        +D   S   E     EDL    I+DLL
Subjt:  DDNATSTTSEAIMNLEDLPSFNIDDLL

TYK18071.1 uncharacterized protein E5676_scaffold306G004020 [Cucumis melo var. makuwa]2.4e-2551.94Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY S EPVRIT KGK KVA+T HITVEE  DSE+ K++   R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

TrEMBL top hitse value%identityAlignment
A0A5A7TZU9 Ribonuclease H6.8e-2652.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K+    R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

A0A5A7TZU9 Ribonuclease H2.3e-1844.88Show/hide
Query:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE
        K+  +Q+++V+ GWTLVTRRK RKQ++ QKES  ++ ++ KGKS+R+N +K  R+  PI+EE+E   +P  PI LK+FFP+ F     +IV+CH    TE
Subjt:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE

Query:  DDNATSTTSEAIMNLEDLPSFNIDDLL
        +D   S   E     EDL    I+DLL
Subjt:  DDNATSTTSEAIMNLEDLPSFNIDDLL

A0A5A7TZU9 Ribonuclease H6.8e-2652.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K+    R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

A0A5D3BIH8 Uncharacterized protein2.3e-1844.88Show/hide
Query:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE
        K+  +Q+++V+ GWTLVTRRK RKQ++ QKES  ++ ++ KGKS+R+N +K  R+  PI+EE+E   +P  PI LK+FFP+ F     +IV+CH    TE
Subjt:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE

Query:  DDNATSTTSEAIMNLEDLPSFNIDDLL
        +D   S   E     EDL    I+DLL
Subjt:  DDNATSTTSEAIMNLEDLPSFNIDDLL

A0A5D3BIH8 Uncharacterized protein6.8e-2652.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K+    R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

A0A5D3C783 Ribonuclease H1.2e-2551.94Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY S EPVRIT KGK KVA+T HITVEE  DSE+ K++   R+S FDRI  S  R SVFQR+ST+  +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

A0A5D3D1E5 Ribonuclease H2.3e-1844.88Show/hide
Query:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE
        K+  +Q+++V+ GWTLVTRRK RKQ++ QKES  ++ ++ KGKS+R+N +K  R+  PI+EE+E   +P  PI LK+FFP+ F     +IV+CH    TE
Subjt:  KKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVDVTE

Query:  DDNATSTTSEAIMNLEDLPSFNIDDLL
        +D   S   E     EDL    I+DLL
Subjt:  DDNATSTTSEAIMNLEDLPSFNIDDLL

A0A5D3D1E5 Ribonuclease H6.8e-2652.71Show/hide
Query:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA
        ++I +  AG+GY+S EPVRIT KGKAKVA+T HITVEE  DSE+ K++   R+S FDRI  S  R SVFQR+ST   +D +Q  T  STR SAFQRL+ +
Subjt:  FNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYGSTRPSAFQRLSMA

Query:  SEEKENVHSTPTTRLSAFQRLNIFISHDK
        +++  ++  TPTTR SAF+RL++ ++ D+
Subjt:  SEEKENVHSTPTTRLSAFQRLNIFISHDK

SwissProt top hitse value%identityAlignment
No hits found
Arabidopsis top hitse value%identityAlignment
No hits found

Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGACTTCCCAGAAAGGGCTCTCTACAATGAGGATCTTCAAGAAAAGATTTAGGCAAATTGAAGACGTAGATGGAGGCTGGACACTCGTAACCCGACGGAAGAACCGAAA
GCAAAATTGGGTTCAAAAGGAATCTCGTTTGTTTCAAGAACACAAAATAAAAGGCAAGTCTCGAAGGAAAAATGGGAAGAAGTATATGAGAAGGCTCAAGCCTATCTTAG
AGGAAAATGAGGAGCATATCCAACCTCCACATCCAATAACTCTAAAAGAATTCTTCCCAAGAACTTTTCTTGCAGGAATCAATCAAATTGTTACATGTCATGTCGTTGAT
GTGACAGAAGATGATAATGCTACATCGACTACGTCAGAAGCAATCATGAACCTGGAAGACCTGCCATCCTTCAATATAGATGATTTACTAGCTGGTCTTGGATATAAATC
TCCTGAGCCGGTTCGAATCACAAGAAAAGGGAAAGCGAAAGTTGCAGATACGCTTCACATTACAGTGGAAGAAATCGATGATTCCGAACAGGCTAAAGAAAACATAGATC
ATAGGACTTCTGCATTTGATCGCATTGGACCGTCAGTTACACGATCCTCGGTTTTTCAAAGACTGAGTACAGCTGCAATAGAAGATGAAAGTCAACATCCAACTTATGGC
TCCACACGACCTTCAGCTTTCCAAAGATTAAGTATGGCTTCTGAAGAAAAAGAAAATGTGCATTCAACTCCTACCACACGGCTATCAGCTTTCCAAAGACTTAACATCTT
CATCAGTCATGACAAAGGCACACTCAATATTGGGGATCTCTTCACGGACTTTGGTAACCTCGAGTCTCTGTTGCTTCAAAGTCTTCTCCTCCATCACAAATCAAATTGGA
AAGCCTCTCATGCTCGACTAACGTTGTCTCAAGTTTGGCCTCTAATTCCTTTATCTCCAAGGATGATCGTGCAAGCTGTTGTTCGAGGTTTCACTCGTTTCAAGTTCAAG
TTTGAGCTTTCCTCATTTCAAGTACTTCAAGTTCAAGCTTTCATCGCTTCAAGTACTCTAAGTTCAAGTTCGAGCATTCCTCACTGCAAGTACTTCAAGTTCCAGTTCAA
TCTTCGCTCATTTCAAGTTCAAGTTCGAGCTTTCCTCACTTCAAGTACTCTAAGTTCAAGTTCGGGGGCTTTGCTCGTTTCAACTTCAAGTTCGGGCTTTCCTCACTTCA
AGTACTCTAAGTTCAAGTTCAGGGGCTTCGCTCATTTCAAGTTCAAGTTCGAGTTTTCCTCACTTCAAGTACTTCAAGTTCAAGCTTTCATCTCTTCAAGTGCTTTAAGT
TCAAGTTCAGGGCTTCGCTTGTTTCGAGTTCAAGTTCGAGCTTTCCCCACTACAAGTACTCCAAGTTCTAGTTCAATCTTTTCTCATTTCAAGTTCAAGTTCAAGCTTTC
ATAA
mRNA sequenceShow/hide mRNA sequence
ATGACTTCCCAGAAAGGGCTCTCTACAATGAGGATCTTCAAGAAAAGATTTAGGCAAATTGAAGACGTAGATGGAGGCTGGACACTCGTAACCCGACGGAAGAACCGAAA
GCAAAATTGGGTTCAAAAGGAATCTCGTTTGTTTCAAGAACACAAAATAAAAGGCAAGTCTCGAAGGAAAAATGGGAAGAAGTATATGAGAAGGCTCAAGCCTATCTTAG
AGGAAAATGAGGAGCATATCCAACCTCCACATCCAATAACTCTAAAAGAATTCTTCCCAAGAACTTTTCTTGCAGGAATCAATCAAATTGTTACATGTCATGTCGTTGAT
GTGACAGAAGATGATAATGCTACATCGACTACGTCAGAAGCAATCATGAACCTGGAAGACCTGCCATCCTTCAATATAGATGATTTACTAGCTGGTCTTGGATATAAATC
TCCTGAGCCGGTTCGAATCACAAGAAAAGGGAAAGCGAAAGTTGCAGATACGCTTCACATTACAGTGGAAGAAATCGATGATTCCGAACAGGCTAAAGAAAACATAGATC
ATAGGACTTCTGCATTTGATCGCATTGGACCGTCAGTTACACGATCCTCGGTTTTTCAAAGACTGAGTACAGCTGCAATAGAAGATGAAAGTCAACATCCAACTTATGGC
TCCACACGACCTTCAGCTTTCCAAAGATTAAGTATGGCTTCTGAAGAAAAAGAAAATGTGCATTCAACTCCTACCACACGGCTATCAGCTTTCCAAAGACTTAACATCTT
CATCAGTCATGACAAAGGCACACTCAATATTGGGGATCTCTTCACGGACTTTGGTAACCTCGAGTCTCTGTTGCTTCAAAGTCTTCTCCTCCATCACAAATCAAATTGGA
AAGCCTCTCATGCTCGACTAACGTTGTCTCAAGTTTGGCCTCTAATTCCTTTATCTCCAAGGATGATCGTGCAAGCTGTTGTTCGAGGTTTCACTCGTTTCAAGTTCAAG
TTTGAGCTTTCCTCATTTCAAGTACTTCAAGTTCAAGCTTTCATCGCTTCAAGTACTCTAAGTTCAAGTTCGAGCATTCCTCACTGCAAGTACTTCAAGTTCCAGTTCAA
TCTTCGCTCATTTCAAGTTCAAGTTCGAGCTTTCCTCACTTCAAGTACTCTAAGTTCAAGTTCGGGGGCTTTGCTCGTTTCAACTTCAAGTTCGGGCTTTCCTCACTTCA
AGTACTCTAAGTTCAAGTTCAGGGGCTTCGCTCATTTCAAGTTCAAGTTCGAGTTTTCCTCACTTCAAGTACTTCAAGTTCAAGCTTTCATCTCTTCAAGTGCTTTAAGT
TCAAGTTCAGGGCTTCGCTTGTTTCGAGTTCAAGTTCGAGCTTTCCCCACTACAAGTACTCCAAGTTCTAGTTCAATCTTTTCTCATTTCAAGTTCAAGTTCAAGCTTTC
ATAA
Protein sequenceShow/hide protein sequence
MTSQKGLSTMRIFKKRFRQIEDVDGGWTLVTRRKNRKQNWVQKESRLFQEHKIKGKSRRKNGKKYMRRLKPILEENEEHIQPPHPITLKEFFPRTFLAGINQIVTCHVVD
VTEDDNATSTTSEAIMNLEDLPSFNIDDLLAGLGYKSPEPVRITRKGKAKVADTLHITVEEIDDSEQAKENIDHRTSAFDRIGPSVTRSSVFQRLSTAAIEDESQHPTYG
STRPSAFQRLSMASEEKENVHSTPTTRLSAFQRLNIFISHDKGTLNIGDLFTDFGNLESLLLQSLLLHHKSNWKASHARLTLSQVWPLIPLSPRMIVQAVVRGFTRFKFK
FELSSFQVLQVQAFIASSTLSSSSSIPHCKYFKFQFNLRSFQVQVRAFLTSSTLSSSSGALLVSTSSSGFPHFKYSKFKFRGFAHFKFKFEFSSLQVLQVQAFISSSALS
SSSGLRLFRVQVRAFPTTSTPSSSSIFSHFKFKFKLS