CuGenDBv2

Gene ID	Spg016896
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	3-hydroxy-3-methylglutaryl-coenzyme A reductase 3
Genome location	scaffold9:40727306..40728410
RNA-Seq Expression	Spg016896
Synteny	Spg016896
Gene Ontology terms	GO:0008299 - isoprenoid biosynthetic process (biological process) GO:0015936 - coenzyme A metabolic process (biological process) GO:0005789 - endoplasmic reticulum membrane (cellular component) GO:0016021 - integral component of membrane (cellular component) GO:0004420 - hydroxymethylglutaryl-CoA reductase (NADPH) activity (molecular function)
InterPro domains	IPR002202 - Hydroxymethylglutaryl-CoA reductase, class I/II IPR009023 - Hydroxymethylglutaryl-CoA reductase, class I/II, NAD/NADP-binding domain superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

QTH36770.1 HMG-CoA reductase 3, partial [Siraitia grosvenorii]

2.0e-22

85.07

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Query:  KSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEAL
        K   NVLDFLQ+DFPDMDVIGISGNFC DKKPAAVNW EGR K VVCEAIIK DVVRKVLKTN+EAL
Subjt:  KSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEAL

XP_004144569.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 [Cucumis sativus]

2.6e-22

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+   RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEA+IK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

XP_008451185.1 PREDICTED: 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Cucumis melo]

2.6e-22

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+   RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEA+IK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

XP_023554472.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Cucurbita pepo subsp. pepo]

2.6e-22

56.8

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      S K+  +RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKK AAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEAIIK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

XP_038888927.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1-like [Benincasa hispida]

1.2e-22

56.8

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+  +RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEAIIK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

TrEMBL top hits

e value

%identity

Alignment

A0A0A0K2Z2 3-hydroxy-3-methylglutaryl coenzyme A reductase

1.3e-22

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+   RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEA+IK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

A0A1S3BRZ3 3-hydroxy-3-methylglutaryl coenzyme A reductase

1.3e-22

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+   RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEA+IK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

A0A2P5AA26 3-hydroxy-3-methylglutaryl coenzyme A reductase

1.6e-22

54.84

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Query:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK
        FL   + F T  L+   SS F  L   +G     + K+  +RFS        +    K   NVLDFLQ DFPDMDVIGISGNFC DKKPAAVNW EGR K
Subjt:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK

Query:  YVVCEAIIKDDVVRKVLKTNMEAL
         VVCEA+IK+DVV+KVLKTN++AL
Subjt:  YVVCEAIIKDDVVRKVLKTNMEAL

A0A5A7UUL1 3-hydroxy-3-methylglutaryl coenzyme A reductase

1.3e-22

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+   RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKKPAAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEA+IK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

A0A6J1HV93 3-hydroxy-3-methylglutaryl coenzyme A reductase

3.6e-22

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Query:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV
        +FL     F T  L+   SS F  L + +      + K+   RFS        +    K   NVLDFLQEDFPDMDVIGISGNFC DKK AAVNW EGR 
Subjt:  VFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRV

Query:  KYVVCEAIIKDDVVRKVLKTNMEAL
        K VVCEAIIK DVVRKVLKTN+EAL
Subjt:  KYVVCEAIIKDDVVRKVLKTNMEAL

SwissProt top hits

e value

%identity

Alignment

A0A0A1C3I2 3-hydroxy-3-methylglutaryl coenzyme A reductase 1

8.3e-24

54.03

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Query:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRF-----SHYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK
        FL   L F T  ++   SS F  L S + +    + K+  IRF         +    K   NVL+FLQ DFPDMDVIGISGNFC DKKPAAVNW EGR K
Subjt:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRF-----SHYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK

Query:  YVVCEAIIKDDVVRKVLKTNMEAL
         VVCEAII DDVV+KVLKT + AL
Subjt:  YVVCEAIIKDDVVRKVLKTNMEAL

O64967 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1.4e-23

80.6

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Query:  KSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEAL
        K   NVLDFLQ DFPDMDVIGISGNFC DKKPAAVNW EGR K VVCEAII+ DVVRKVLKT++E+L
Subjt:  KSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEAL

P48021 3-hydroxy-3-methylglutaryl-coenzyme A reductase

7.1e-23

50.81

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Query:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK
        FL   L F T   +   SS F  L + +      + K+  +R+S        +    K   NVLDFLQ+DFPDMDVIGISGN+C DKKPAAVNW EGR K
Subjt:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK

Query:  YVVCEAIIKDDVVRKVLKTNMEAL
         VVCEA+IK++VV+KVLKTN+ +L
Subjt:  YVVCEAIIKDDVVRKVLKTNMEAL

Q9XHL5 3-hydroxy-3-methylglutaryl-coenzyme A reductase 3

8.3e-24

50.81

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Query:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK
        FL  ++ F+T  ++   SS F  L   +G     + ++  +RFS        +    K   NVLD+LQ+DFPDMDVI ISGNFC DKKPAAVNW EGR K
Subjt:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK

Query:  YVVCEAIIKDDVVRKVLKTNMEAL
         VVCEA+IK+DVV+KVLKTN+++L
Subjt:  YVVCEAIIKDDVVRKVLKTNMEAL

U5JCC6 3-hydroxy-3-methylglutaryl coenzyme A reductase 2-B

3.2e-23

52.42

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Query:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK
        FL   + F T  L+   SS F  L   +G     + K+  +RF+        +    K   NVLDFLQ DFPDMDV+GISGN+C DKKPAAVNW EGR K
Subjt:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFS-----HYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK

Query:  YVVCEAIIKDDVVRKVLKTNMEAL
         VVCEAIIK++VV+KVLKTN+ AL
Subjt:  YVVCEAIIKDDVVRKVLKTNMEAL

Arabidopsis top hits

e value

%identity

Alignment

AT1G76490.1 hydroxy methylglutaryl CoA reductase 1

1.0e-21

47.58

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Query:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRF-----SHYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK
        FL     F T  ++   SS F  L S +      + K+  +RF         +    K   NVL++L +DFPDMDVIGISGNFC DKKPAAVNW EGR K
Subjt:  FLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRF-----SHYFVIFADKSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVK

Query:  YVVCEAIIKDDVVRKVLKTNMEAL
         VVCEA+I+ ++V KVLKT++ AL
Subjt:  YVVCEAIIKDDVVRKVLKTNMEAL

AT2G17370.1 3-hydroxy-3-methylglutaryl-CoA reductase 2

1.8e-21

68.66

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Query:  KSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEAL
        K   NVLDF++ +FPDMDVIGISGN+C DKK +AVNW EGR K+VVCEA IK ++V KVLKT++EAL
Subjt:  KSTSNVLDFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEAL

Sequences

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CDS sequence

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CGTGAAAAGTCCGCTAACCTCTGTAGCGTATTTCGCAAGCGACTCTTCCGTATAAATTCATTCCCGCCATCACGTTTTAACTTCACAATCATTCTTGAGGCTTACCTTTC
ATTAATGGTTGAAGCATTTCCCTGGTTAGAGTTCTCTCTCGTCTTTCTCAGTTTTGCCCTAGGATTTTCTACTAGGGTTTTGTTATTGCCTGGTTCTTCGAATTTCATGG
CATTACCATCTTTCCGAGGCAATGATGATTTGAGATCAGAAAAGTCTCGGAGTATTAGATTTTCTCACTATTTCGTCATCTTCGCCGATAAGAGCACATCGAACGTTCTC
GATTTCTTACAGGAGGATTTCCCTGACATGGATGTAATCGGCATTTCCGGAAATTTCTGCTTGGATAAGAAACCGGCTGCTGTGAACTGGGATGAAGGAAGGGTGAAGTA
CGTGGTTTGTGAGGCCATAATTAAAGACGATGTGGTGAGGAAGGTATTGAAAACAAACATGGAGGCTCTGGCCACGTGA

mRNA sequence

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Protein sequence

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REKSANLCSVFRKRLFRINSFPPSRFNFTIILEAYLSLMVEAFPWLEFSLVFLSFALGFSTRVLLLPGSSNFMALPSFRGNDDLRSEKSRSIRFSHYFVIFADKSTSNVL
DFLQEDFPDMDVIGISGNFCLDKKPAAVNWDEGRVKYVVCEAIIKDDVVRKVLKTNMEALAT

Spg016896 (gene) of Sponge gourd (cylindrica) v1 genome