CuGenDBv2

Gene ID	Spg022719
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	DNA annealing helicase and endonuclease ZRANB3
Genome location	scaffold2:4639754..4645403
RNA-Seq Expression	Spg022719
Synteny	Spg022719
Gene Ontology terms	GO:0006281 - DNA repair (biological process) GO:0031297 - replication fork processing (biological process) GO:0048478 - replication fork protection (biological process) GO:0090305 - nucleic acid phosphodiester bond hydrolysis (biological process) GO:0043596 - nuclear replication fork (cellular component) GO:0003676 - nucleic acid binding (molecular function) GO:0004386 - helicase activity (molecular function) GO:0004520 - endodeoxyribonuclease activity (molecular function) GO:0005524 - ATP binding (molecular function)
InterPro domains	IPR002711 - HNH endonuclease IPR003615 - HNH nuclease

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6589530.1 DNA annealing helicase and endonuclease ZRANB3, partial [Cucurbita argyrosperma subsp. sororia]

9.8e-87

77.31

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   + +      +ELFQMEHGVCSNCHLDCHKLVKHIRPLS+DMRRDYIEKVAP LASRK LL+K+VNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKKQLRDTITD+KK  NTE IDN+IQN+VHD QENV+D+QLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGEST
        KDDCLDNNTEGP EST
Subjt:  KDDCLDNNTEGPGEST

KAG7023215.1 DNA annealing helicase and endonuclease ZRANB3, partial [Cucurbita argyrosperma subsp. argyrosperma]

2.8e-86

76.85

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   + +      +ELFQMEHGVCSNCHLDCHKLVKHIRPLS++MRRDYIEKVAP LASRK LL+K+VNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKKQLRDTITD+KK  NTE IDN+IQN+VHD QENV+D+QLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGEST
        KDDCLDNNTEGP EST
Subjt:  KDDCLDNNTEGPGEST

XP_022134708.1 DNA annealing helicase and endonuclease ZRANB3 [Momordica charantia]

4.4e-87

77.98

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE +ED     L   +   + +      +ELFQMEHGVCSNCHLDCHKLVKHI+PLSLDMRRDYIEKVAPNLASRKKLL+KIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAW+ADHIVPVYRGGGECRLENMRTLCVACH DVTA+QRAERRLVRLKAKKQLRDTIT LKKGGNTE  DNNIQNQVHD QENVVDDQLI+VKVPGS+YS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGESTGA
        KDD LDN+T+ PGES GA
Subjt:  KDDCLDNNTEGPGESTGA

XP_023516624.1 DNA annealing helicase and endonuclease ZRANB3 [Cucurbita pepo subsp. pepo]

1.7e-86

76.61

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   + +      +ELFQMEHGVCSNCHLDCHKLVKHIRPLS++MRRDYIEKVAP LASRK LL+KIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCV CHFDVTA+QRAERRLVRLKAKKQLRDTITD+KK  NTE IDN+IQN+VHD QENV+D+QLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGESTGA
        KDDCLDNNTEGP EST A
Subjt:  KDDCLDNNTEGPGESTGA

XP_038880755.1 DNA annealing helicase and endonuclease ZRANB3-like isoform X1 [Benincasa hispida]

3.7e-86

77.63

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   I +      +ELFQ+E GVCSNCHLDCHKLVKHIRPL+LDMR DYIEKVAPNLA RKKLLDKIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKKQLRDTITD+KKGGNTE ID NIQ ++HD QENV+DDQLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLD-NNTEGPGESTGA
        KDDCLD NNTEGP ES GA
Subjt:  KDDCLD-NNTEGPGESTGA

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LPG8 Uncharacterized protein

5.8e-85

75.11

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE +ED     L   +   + +      +ELFQMEHGVCSNC LDCHKLVKHI+PL+LDMRRDYIEKVAPNLASRKKLL+KIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNT-EIDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKKQL+D I D+KKGGNT  ID +IQ QVHD QE+V+DDQLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNT-EIDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCL---DNNTEGPGESTGA
        KDDCL   +NN EGPGESTGA
Subjt:  KDDCL---DNNTEGPGESTGA

A0A6J1C2S2 DNA annealing helicase and endonuclease ZRANB3

2.1e-87

77.98

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE +ED     L   +   + +      +ELFQMEHGVCSNCHLDCHKLVKHI+PLSLDMRRDYIEKVAPNLASRKKLL+KIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAW+ADHIVPVYRGGGECRLENMRTLCVACH DVTA+QRAERRLVRLKAKKQLRDTIT LKKGGNTE  DNNIQNQVHD QENVVDDQLI+VKVPGS+YS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGESTGA
        KDD LDN+T+ PGES GA
Subjt:  KDDCLDNNTEGPGESTGA

A0A6J1E1Z4 DNA annealing helicase and endonuclease ZRANB3 isoform X1

7.6e-85

75.23

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   + +      +ELFQMEHGVCSNCHLDCHKLVKHIRPLS++MRRDYIEKVAP L SRK LL+ IVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKKQLRDTITD+KK  NTE IDN+IQN+VH+ QENV+D+QLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGESTGA
        KDDCLDNNT GP EST A
Subjt:  KDDCLDNNTEGPGESTGA

A0A6J1JAQ4 DNA annealing helicase and endonuclease ZRANB3 isoform X2

4.0e-86

76.15

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   + +      +ELFQMEHGVCS CHLDCHKLVKHIRPLS++MRRDYIEKVAP LASRK LL+KIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKK+LRDTITD+KK  NTE IDN+IQN+VHD QENV+D+QLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGESTGA
        KDDCLDNNTEGP EST A
Subjt:  KDDCLDNNTEGPGESTGA

A0A6J1JEM2 DNA annealing helicase and endonuclease ZRANB3 isoform X1

4.0e-86

76.15

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        Q P + ++ K+PE  ED     L   +   + +      +ELFQMEHGVCS CHLDCHKLVKHIRPLS++MRRDYIEKVAP LASRK LL+KIVNNPTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS
        NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA+QRAERRLVRLKAKK+LRDTITD+KK  NTE IDN+IQN+VHD QENV+D+QLI+VKVPGSAYS
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTE-IDNNIQNQVHDTQENVVDDQLIIVKVPGSAYS

Query:  KDDCLDNNTEGPGESTGA
        KDDCLDNNTEGP EST A
Subjt:  KDDCLDNNTEGPGESTGA

SwissProt top hits

e value

%identity

Alignment

E1BB03 DNA annealing helicase and endonuclease ZRANB3

2.5e-16

36.79

Show/hide

Query:  ELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRA
        ++F++EHGVC  C+L+  +L   +R      R+  ++    +    ++ L++++ +P EG+ W  DHI PV  GGG+C L+N++TLC  CH + TA+Q  
Subjt:  ELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRA

Query:  ERRLVR
        ER  VR
Subjt:  ERRLVR

Q5FWF4 DNA annealing helicase and endonuclease ZRANB3

3.8e-17

37.74

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Query:  ELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRA
        ++F+ EHGVC  C+++  +L   +R      R++ +     +    ++ L++++ NP EG+ W  DHI PVY GGG+C L+N++TLC  CH + TA+Q  
Subjt:  ELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRA

Query:  ERRLVR
        ER  VR
Subjt:  ERRLVR

Q6NZP1 DNA annealing helicase and endonuclease ZRANB3

2.2e-17

40.91

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Query:  ELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKL----LDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA
        ++F  EHGVC +C +D  +L   +R      R+  +     N A   KL    L++++ NP EG+ W  DHI PVY GGG+C L+N++TLC  CH + TA
Subjt:  ELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKL----LDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTA

Query:  KQRAERRLVR
        +Q  ER  VR
Subjt:  KQRAERRLVR

Arabidopsis top hits

e value

%identity

Alignment

AT5G07810.1 SNF2 domain-containing protein / helicase domain-containing protein / HNH endonuclease domain-containing protein

8.3e-52

50.95

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Query:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG
        QKP    + K PE +ED    +    D +  +  + ++     Q+EHG+C+NC LDCH+LVK +RPL L+ RR YI K AP L +RK LL+ +VN+PTEG
Subjt:  QKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDYIEKVAPNLASRKKLLDKIVNNPTEG

Query:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLK---KGGNTEIDNNIQNQVHDTQENVVDDQLIIVKVPGSA
        NAWHADHI+PVY+GGGECRLENMRTLCVACH DVTA Q AER+L+R KA+KQL++T+ +L+   K  +   D N +    D+  N  +D+L+I +VPGSA
Subjt:  NAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLK---KGGNTEIDNNIQNQVHDTQENVVDDQLIIVKVPGSA

Query:  YSKDDCLDNN
        YS D  ++++
Subjt:  YSKDDCLDNN

Sequences

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CDS sequence

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ATGATAACTTCTATTTCCATGAACCTCCTTCTAGGAAAAACCCTACCCTCCCCACTGGACAGAGCTCCAGCGCCCAATACACCCAACACACCCTCACCAGACACTCAAAA
ACCCCACCGGAAAGTTCATCGGAAGTCACCGGAGGTCATGGAAGATGGGAGAGAAATTGTCTTGTTGAAGTCAGACGCCCAAGCTATATCAGTTATCAAATGCTTGAAAT
ACCAGGAACTGTTTCAAATGGAGCATGGTGTCTGCTCAAATTGTCATTTGGACTGTCATAAGCTCGTAAAGCACATAAGACCATTATCCTTGGACATGCGGCGTGATTAT
ATTGAGAAAGTAGCACCTAATTTGGCAAGCCGGAAAAAGTTGCTTGATAAGATTGTTAATAATCCAACTGAGGGCAACGCATGGCACGCCGACCACATTGTTCCTGTTTA
CCGAGGTGGAGGTGAGTGCAGGCTAGAGAATATGAGGACCCTTTGTGTGGCATGTCATTTTGATGTTACTGCAAAACAACGTGCTGAACGACGATTAGTTCGGCTCAAAG
CTAAGAAACAACTTAGAGACACTATCACTGATCTCAAGAAAGGTGGAAACACTGAGATCGATAACAACATTCAGAATCAAGTACATGATACGCAAGAGAATGTAGTTGAT
GATCAGCTAATCATAGTGAAGGTTCCTGGAAGTGCTTACTCCAAAGACGACTGCTTAGACAATAATACAGAGGGCCCTGGAGAGTCCACAGGAGCTTAG

mRNA sequence

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Protein sequence

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MITSISMNLLLGKTLPSPLDRAPAPNTPNTPSPDTQKPHRKVHRKSPEVMEDGREIVLLKSDAQAISVIKCLKYQELFQMEHGVCSNCHLDCHKLVKHIRPLSLDMRRDY
IEKVAPNLASRKKLLDKIVNNPTEGNAWHADHIVPVYRGGGECRLENMRTLCVACHFDVTAKQRAERRLVRLKAKKQLRDTITDLKKGGNTEIDNNIQNQVHDTQENVVD
DQLIIVKVPGSAYSKDDCLDNNTEGPGESTGA

Spg022719 (gene) of Sponge gourd (cylindrica) v1 genome