CuGenDBv2

Gene ID	Spg023612
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	DNA topoisomerase 2
Genome location	scaffold13:4231223..4231702
RNA-Seq Expression	Spg023612
Synteny	Spg023612
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0043231 - intracellular membrane-bounded organelle (cellular component) GO:0003677 - DNA binding (molecular function) GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity (molecular function) GO:0005524 - ATP binding (molecular function) GO:0046872 - metal ion binding (molecular function)
InterPro domains	IPR003594 - Histidine kinase/HSP90-like ATPase IPR036890 - Histidine kinase/HSP90-like ATPase superfamily

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7018075.1 DNA topoisomerase 2 [Cucurbita argyrosperma subsp. argyrosperma]

3.9e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

XP_022935016.1 DNA topoisomerase 2 isoform X2 [Cucurbita moschata]

3.9e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

XP_022982562.1 DNA topoisomerase 2 isoform X1 [Cucurbita maxima]

3.0e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

XP_022982563.1 DNA topoisomerase 2 isoform X2 [Cucurbita maxima]

3.0e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

XP_023527826.1 DNA topoisomerase 2 isoform X6 [Cucurbita pepo subsp. pepo]

3.9e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LEU2 DNA topoisomerase 2

1.9e-33

93.75

Show/hide

Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDSVKV IDVEQN ISVFNNGDGVPVE+HQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

A0A5A7TZH5 DNA topoisomerase 2

1.9e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDSVKV IDVEQN ISVFNNGDGVPVE+HQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

A0A5B7BLD1 DNA topoisomerase 2 (Fragment)

8.5e-34

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDSVKVVIDVEQNSISV+NNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDT KKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

A0A6J1IWX9 DNA topoisomerase 2

1.5e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

A0A6J1J555 DNA topoisomerase 2

1.5e-33

93.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KVVID EQN ISVFNNGDGVPVEVHQEE VYVPELIFGHLLTSSNYDDTEKKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

SwissProt top hits

e value

%identity

Alignment

O24308 DNA topoisomerase 2

5.3e-33

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRDPSMDS+KV ID E N++SV+NNGDGVPVE+HQEE VYVPELIFGHLLTSSNYDD  KKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

P08096 DNA topoisomerase 2

7.5e-27

66.25

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EI+VNAADNK RDP+M+++KV +D E N IS++NNG G+P+E+H +E +Y+PELIFG+LLTSSNYDD +KK TGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

P15348 DNA topoisomerase 2

2.2e-26

68.75

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRD SM+++K+ ID E+N +SV+NNG G+PV +H+E+ +YVP +IFGHLLTSSNY+D EKK TGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

P30182 DNA topoisomerase 2

1.1e-30

82.5

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Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRD  MDSV+VVIDVEQN ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

Q01879 DNA topoisomerase 2

1.5e-27

65.17

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Query:  HLCAWSLQDFYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        H+     + F EILVNAADNK RDPSM ++KV ID E N+ISV N+G G+P+E+H++E +Y+PELIFG+LLTSSNYDD EKK TGGRNG
Subjt:  HLCAWSLQDFYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

Arabidopsis top hits

e value

%identity

Alignment

AT3G23890.1 topoisomerase II

7.9e-32

82.5

Show/hide

Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRD  MDSV+VVIDVEQN ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

AT3G23890.2 topoisomerase II

7.9e-32

82.5

Show/hide

Query:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG
        F EILVNAADNKQRD  MDSV+VVIDVEQN ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNG
Subjt:  FYEILVNAADNKQRDPSMDSVKVVIDVEQNSISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

Sequences

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CDS sequence

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ATGGCCGTGGAGAAGCGCACTGCAGAACAGCACCGCCGCCAATGTCGACCAGATTCCGGCAGGGTCGAAGAAAACAATCGAAGAAATGTACCAGAAGAAGACCCAGCTCG
AGCACATCCTTCTCAGGCCCGATACCTATGTTGGATCAATCGAAAAGCACACCCAAAACCTCTGGGTTTACGAGAACGACAAGATGGTCAACCGATCCGTCACTTATGTG
CCTGGTCTCTACAAGATTTTTATGAAATCTTGGTCAATGCCGCCGATAATAAGCAGAGAGACCCCTCCATGGACTCGGTCAAAGTTGTAATCGATGTTGAACAGAACTCT
ATCAGCGTGTTCAACAATGGAGATGGAGTTCCGGTTGAGGTTCATCAGGAAGAGAATGTTTATGTGCCTGAATTGATCTTTGGACATCTGTTGACCAGTAGTAATTACGA
TGATACTGAGAAGAAAACCACCGGTGGACGCAACGGCTAG

mRNA sequence

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Protein sequence

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MAVEKRTAEQHRRQCRPDSGRVEENNRRNVPEEDPARAHPSQARYLCWINRKAHPKPLGLRERQDGQPIRHLCAWSLQDFYEILVNAADNKQRDPSMDSVKVVIDVEQNS
ISVFNNGDGVPVEVHQEENVYVPELIFGHLLTSSNYDDTEKKTTGGRNG

Spg023612 (gene) of Sponge gourd (cylindrica) v1 genome