CuGenDBv2

Gene ID	Spg034414
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	3-hydroxyisobutyrate dehydrogenase
Genome location	scaffold12:23644749..23646080
RNA-Seq Expression	Spg034414
Synteny	Spg034414
Gene Ontology terms	GO:0006551 - leucine metabolic process (biological process) GO:0006574 - valine catabolic process (biological process) GO:0008442 - 3-hydroxyisobutyrate dehydrogenase activity (molecular function) GO:0043621 - protein self-association (molecular function) GO:0050661 - NADP binding (molecular function) GO:0051287 - NAD binding (molecular function)
InterPro domains	IPR006115 - 6-phosphogluconate dehydrogenase, NADP-binding IPR036291 - NAD(P)-binding domain superfamily

Homology

Show/hide homology

GenBank top hits

e value

%identity

Alignment

KAG6583846.1 putative 3-hydroxyisobutyrate dehydrogenase, mitochondrial, partial [Cucurbita argyrosperma subsp. sororia]

4.4e-37

95.24

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

KAG7019466.1 putative 3-hydroxyisobutyrate dehydrogenase, mitochondrial [Cucurbita argyrosperma subsp. argyrosperma]

4.4e-37

95.24

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

XP_022927542.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X2 [Cucurbita moschata]

4.4e-37

95.24

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Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

XP_023000831.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X2 [Cucurbita maxima]

4.4e-37

95.24

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Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

XP_023520240.1 probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial isoform X1 [Cucurbita pepo subsp. pepo]

4.4e-37

95.24

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

TrEMBL top hits

e value

%identity

Alignment

A0A0A0M152 3-hydroxyisobutyrate dehydrogenase

1.4e-36

91.86

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGT
        MK YSD+GVATKETPFEVAEASDVVITMLP PSHVLDVYNGSHGLLHGG H+RPWLLIDSSTIDP+TSRELSAVVSSRILKEKRG+
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGT

A0A6J1EHG8 3-hydroxyisobutyrate dehydrogenase

2.1e-37

95.24

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

A0A6J1EHZ4 3-hydroxyisobutyrate dehydrogenase

2.1e-37

95.24

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Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

A0A6J1KER6 3-hydroxyisobutyrate dehydrogenase

2.1e-37

95.24

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

A0A6J1KJE2 3-hydroxyisobutyrate dehydrogenase

2.1e-37

95.24

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        M+KYSDMGVATKETPFEVAEASDVVITMLP PSHVL+VYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSA+VSSRILKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

SwissProt top hits

e value

%identity

Alignment

P31937 3-hydroxyisobutyrate dehydrogenase, mitochondrial

4.5e-08

39.77

Show/hide

Query:  KKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFL
        K++ D G     +P +VAE +D +ITMLP   + ++ Y+G++G+L      +  LLIDSSTIDP  S+EL+  V      EK G  F+
Subjt:  KKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFL

Q54CX6 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

4.1e-09

42.67

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRP-WLLIDSSTIDPRTSRELSAV
        M +  + G     +P EVA+ +DV++TMLP  +HV +VY G +G+      +RP  LL+DSSTIDP T+RE++++
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRP-WLLIDSSTIDPRTSRELSAV

Q5R5E7 3-hydroxyisobutyrate dehydrogenase, mitochondrial

4.5e-08

39.77

Show/hide

Query:  KKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFL
        K++ D G     +P +VAE +D +ITMLP   + ++ Y+G++G+L      +  LLIDSSTIDP  S+EL+  V      EK G  F+
Subjt:  KKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFL

Q99L13 3-hydroxyisobutyrate dehydrogenase, mitochondrial

1.5e-08

40.91

Show/hide

Query:  KKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFL
        K++ + G     +P EVAE +D +ITMLP   + ++VY+G++G+L      +  LLIDSSTIDP  S+EL+  V      EK G  F+
Subjt:  KKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFL

Q9SUC0 Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

9.3e-22

60.71

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        MK +++MGV+++ETP+EVA+ S+VVITMLP  SHV+DVY G++GLL G   +RP L IDSSTIDP+T+R++S  VS+  LKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

Arabidopsis top hits

e value

%identity

Alignment

AT4G20930.1 6-phosphogluconate dehydrogenase family protein

6.6e-23

60.71

Show/hide

Query:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR
        MK +++MGV+++ETP+EVA+ S+VVITMLP  SHV+DVY G++GLL G   +RP L IDSSTIDP+T+R++S  VS+  LKEKR
Subjt:  MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKR

AT4G29120.1 6-phosphogluconate dehydrogenase family protein

2.4e-04

36.84

Show/hide

Query:  DMGVATKETPFEVAEASDVVITMLPFPSHV----LDVYNGS-HGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVS
        DMG    ++P  VAE SDVV T++ +PS V    LD  +G+  GL  GG      +L+D +T +P  + E++   S
Subjt:  DMGVATKETPFEVAEASDVVITMLPFPSHV----LDVYNGS-HGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVS

Sequences

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CDS sequence

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ATGAAGAAGTACTCAGATATGGGAGTTGCCACCAAAGAAACACCTTTTGAAGTTGCAGAAGCTTCTGACGTTGTCATTACAATGCTACCCTTTCCTTCTCATGTGCTTGA
TGTGTATAATGGTTCACATGGTTTACTCCATGGTGGCTATCATCTAAGGCCGTGGTTATTAATAGACTCCTCCACCATTGATCCACGAACATCAAGAGAGCTTTCAGCAG
TTGTATCTAGCCGTATTTTAAAGGAAAAGAGAGGTACCTGTTTTTTAATCAAAGTACTAGGAAGAGTCATTAAGTACAATATGACTCATCTTGGAACTTCTGTATTGATT
GACTTTGAAAATATGAAATCTCATCCAGTTTAA

mRNA sequence

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Protein sequence

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MKKYSDMGVATKETPFEVAEASDVVITMLPFPSHVLDVYNGSHGLLHGGYHLRPWLLIDSSTIDPRTSRELSAVVSSRILKEKRGTCFLIKVLGRVIKYNMTHLGTSVLI
DFENMKSHPV

Spg034414 (gene) of Sponge gourd (cylindrica) v1 genome