CuGenDBv2

Gene ID	Spg037580
Organism	Luffa cylindrica (Sponge gourd (cylindrica) v1)
Description	2-(3-amino-3-carboxypropyl)histidine synthase subunit 2
Genome location	scaffold11:32071493..32074281
RNA-Seq Expression	Spg037580
Synteny	Spg037580
Gene Ontology terms	GO:0017183 - peptidyl-diphthamide biosynthetic process from peptidyl-histidine (biological process) GO:0016021 - integral component of membrane (cellular component) GO:0090560 - 2-(3-amino-3-carboxypropyl)histidine synthase activity (molecular function)
InterPro domains	IPR010014 - Diphthamide synthesis DHP2 IPR016435 - Diphthamide synthesis DPH1/DPH2

Homology

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GenBank top hits

e value

%identity

Alignment

KAG6597669.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2, partial [Cucurbita argyrosperma subsp. sororia]

1.7e-53

85.5

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI+F  PNEGNRSDEARYSFL+G YVED DSQEN EEENEA ALVSATEK LQ+RDNR+SLIEGTARSGAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
         NGSSQPEPYL+GRSGRASGY+DEKN QEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

KAG7029112.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Cucurbita argyrosperma subsp. argyrosperma]

5.9e-54

86.26

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI+F  PNEGNRSDEARYSFL+G YVED DSQEN EEENEA ALVSATEKALQ+RDNR+SLIEGTARSGAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
         NGSSQPEPYL+GRSGRASGY+DEKN QEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

XP_022158396.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X1 [Momordica charantia]

7.7e-54

84.73

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI FSTP EGNRSDEAR+SFL+GGYVEDCDSQE+ EEE+EA ALVSATEKALQLRDN+NSL  GTAR+GAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
        +NG SQPEPYL+GRSG+ASGYRDEKNRQEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

XP_022158398.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X2 [Momordica charantia]

7.7e-54

84.73

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI FSTP EGNRSDEAR+SFL+GGYVEDCDSQE+ EEE+EA ALVSATEKALQLRDN+NSL  GTAR+GAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
        +NG SQPEPYL+GRSG+ASGYRDEKNRQEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

XP_023541019.1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 [Cucurbita pepo subsp. pepo]

1.5e-54

87.02

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI+F  PNEGNRSDEARYSFL+G YVED DSQEN EEENEA ALVSATEKALQ+RDNRNSLIEGTARSGAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
         NGSSQPEPYL+GRSGRASGY+DEKN QEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

TrEMBL top hits

e value

%identity

Alignment

A0A0A0KW05 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

4.1e-53

85.83

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLIDFSTP E NRSDEARYSFL+GGYVED DSQEN EEEN A ALV+ATEKALQLRDNRNSLIEGTARSGAEFFA RSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNR
        NNGS +PEPY++GRSG+ASGY+DEKNR
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNR

A0A6J1DVZ3 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 isoform X2

3.7e-54

84.73

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI FSTP EGNRSDEAR+SFL+GGYVEDCDSQE+ EEE+EA ALVSATEKALQLRDN+NSL  GTAR+GAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
        +NG SQPEPYL+GRSG+ASGYRDEKNRQEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

A0A6J1E0S8 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

3.7e-54

84.73

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI FSTP EGNRSDEAR+SFL+GGYVEDCDSQE+ EEE+EA ALVSATEKALQLRDN+NSL  GTAR+GAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE
        +NG SQPEPYL+GRSG+ASGYRDEKNRQEE+
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

A0A6J1EXA1 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

8.3e-54

86.72

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAY+MEFQDLI+F  PNEGNRSDEARYSFL+G YVED DSQEN EEENEA ALVSATEKALQ+RDNRNSLIEGTARSGAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKNRQ
         NGSSQPEPYL+GRSGRASGY+DEKN Q
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKNRQ

A0A6J1I4D3 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

5.4e-53

87.3

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Query:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI
        F  GSQWTGAYVMEFQDLI+FS P EGNRSDEARYSFL+G YVED DSQEN EEENEA  LVSATEKALQ+RDNRNSLIEGTARSGAEFFAARSF+GLDI
Subjt:  FEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSATEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDI

Query:  NNGSSQPEPYLMGRSGRASGYRDEKN
         NGSSQPEPYL+GRSGRASGY+DEKN
Subjt:  NNGSSQPEPYLMGRSGRASGYRDEKN

SwissProt top hits	e value	%identity	Alignment
No hits found

Arabidopsis top hits

e value

%identity

Alignment

AT3G59630.1 diphthamide synthesis DPH2 family protein

2.2e-27

52.17

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Query:  EGKERFEWGSQWTGAYVMEFQDLIDFSTPNEGNR---SDEARYSFLKGGYVED---CDSQENGEEE-NEALALVSATEKALQLRDN-RNSLIEGT-ARSG
        E    F  GS+WTGAY+M FQD+I+ S  +E      S+E R+SF +GGYVED    D  +NGEE+  E + LV A EKALQLR N  NSL + T A+SG
Subjt:  EGKERFEWGSQWTGAYVMEFQDLIDFSTPNEGNR---SDEARYSFLKGGYVED---CDSQENGEEE-NEALALVSATEKALQLRDN-RNSLIEGT-ARSG

Query:  AEFFAARSFRGLDINNGSSQPEPYLMGRSGRASGYRDE
         E+F  R +RGL+IN+ ++ PEPY++GRSG+ASGY+ E
Subjt:  AEFFAARSFRGLDINNGSSQPEPYLMGRSGRASGYRDE

Sequences

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CDS sequence

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ATGTTTCGGGCGGAACGGACGGCGATGACTGGGTTTCAGGTGAAACGGACGCGCGACGACTGGGCTTCAGGCGGAACAGACGGCGACGACCGACGGAAGGGGCTGCGTAC
GACGGGGAGAGAAGAAGGGAAAGAGAGATTTGAATGGGGGAGTCAATGGACGGGTGCCTACGTTATGGAATTTCAGGATTTGATTGATTTCTCAACACCTAATGAAGGAA
ACCGATCAGATGAAGCACGATATTCTTTCTTGAAAGGTGGATATGTTGAAGATTGTGATTCCCAAGAAAATGGTGAGGAAGAAAATGAAGCTTTGGCTCTAGTAAGTGCA
ACAGAGAAGGCTCTCCAGTTACGCGATAATCGAAACTCACTGATTGAGGGAACTGCCAGATCCGGAGCAGAATTTTTTGCAGCTCGTTCCTTTCGAGGTTTAGATATTAA
CAATGGTAGCTCCCAGCCAGAGCCATATCTAATGGGGAGGAGCGGCAGGGCGTCCGGGTATCGAGACGAGAAAAACAGGCAAGAAGAAGAATAA

mRNA sequence

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Protein sequence

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MFRAERTAMTGFQVKRTRDDWASGGTDGDDRRKGLRTTGREEGKERFEWGSQWTGAYVMEFQDLIDFSTPNEGNRSDEARYSFLKGGYVEDCDSQENGEEENEALALVSA
TEKALQLRDNRNSLIEGTARSGAEFFAARSFRGLDINNGSSQPEPYLMGRSGRASGYRDEKNRQEEE

Spg037580 (gene) of Sponge gourd (cylindrica) v1 genome