| GenBank top hits | e value | %identity | Alignment |
|---|
| KAG6581568.1 DNA topoisomerase 2, partial [Cucurbita argyrosperma subsp. sororia] | 6.4e-114 | 67 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
EIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGA +ETDE E+ E VKGERVSDYEYLL +AIGTL I+KVQELCNERDK K EVE+L+KATPKS
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
Query: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
LWL DLD EKELDEMDRNDAQA+E+R++QRIK NN+ KPKISRNAPKAP +N VVKPKGKAAPRKA AKK
Subjt: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Q KA V++D ++DDEVLELK RLAAYK++SSP+ EV +ETEV + KKKEP+KRAA K K TAKS Q S DSDD DFEI EI PPA KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Query: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
GGRKAAANAKTTK KK+EP+ +LGQKL+TQMLEP ENS IS EKKVRKIR SPFNKKSGS LGR +G EEE EE GNEGKM+ S
Subjt: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
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| KAG7018075.1 DNA topoisomerase 2 [Cucurbita argyrosperma subsp. argyrosperma] | 1.5e-115 | 67.51 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
EIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGA +ETDE E+ E VKGERVSDYEYLL +AIGTL I+KVQELCNERDK K EVE+L+KATPKS
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
Query: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
LWL DLD EKELDEMDRNDAQA+E+R++QRIK NN+ KPKISRNAPKAP +N VVKPKGKAAPRKA AKK
Subjt: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Q KA V++D ++DDEVLELKDRLAAYK++SSP+ EV +ETEV + KKKEP+KRAA KKK TAKS Q S DSDD DFEI EI PPA KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Query: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
GGRKAAANAKTTK KK+EP+ +LGQKL+TQMLEP ENS IS EKKVRKIR SPFNKKSGS LGR +G EEE EE GNEGKM+ S
Subjt: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
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| XP_022152631.1 DNA topoisomerase 2 isoform X1 [Momordica charantia] | 6.2e-117 | 67.17 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
EI+V NRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGA +ETDE E+ E KGERVSDY YLL +AIGTL I+KVQELCN+RD+LK EVEDL+KATPKSL
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
Query: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
WL DLD+ EKELDEMDRNDAQAEE+R++QRIK NN+ KPKISRN APKAP SNAVVKPKGKAAPRKA AKK +
Subjt: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
Query: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRG
VVN + +++DDEVLELKDRLAAYKIDSSPDR EV +ETEV + KKKEP+KRA KKK TAKS Q + DSDD DFEI E+ PPA KK
Subjt: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRG
Query: VPPTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
GG + AANAKTTK PAAAKKRE KLGQKL+TQML P +N+ IS EKKVRK+RASPFNKKSGS LGRVG EEEEEG GNEGK++ S
Subjt: VPPTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
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| XP_022152632.1 DNA topoisomerase 2 isoform X2 [Momordica charantia] | 5.6e-118 | 67.25 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
EI+V NRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGA +ETDE E+ E KGERVSDY YLL +AIGTL I+KVQELCN+RD+LK EVEDL+KATPKSL
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
Query: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
WL DLD+ EKELDEMDRNDAQAEE+R++QRIK NN+ KPKISRN APKAP SNAVVKPKGKAAPRKA AKK +
Subjt: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
Query: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRGVP
VVN + +++DDEVLELKDRLAAYKIDSSPDR E +ETEV + KKKEP+KRA KKK TAKS Q + DSDD DFEI E+ PPA KK
Subjt: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRGVP
Query: PTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
GG + AANAKTTK PAAAKKRE KLGQKL+TQML P +N+ IS EKKVRK+RASPFNKKSGS LGRVG EEEEEG GNEGK++ S
Subjt: PTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
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| XP_022982562.1 DNA topoisomerase 2 isoform X1 [Cucurbita maxima] | 1.7e-114 | 67.76 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
EIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGA +ETDE E+ E VKGERVSDYEYLL +AIGTL I+KVQELCNERDK K EVE+L+KATPKS
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
Query: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
LWL DLD EKELDEMDRNDAQA+E+R++QRIK NN+ KPKISRNAPKAP +N VVKPKGKAAPRKA AKK
Subjt: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Q KA V++D G DDEVLELKDRLAAYK++SSP+ EV +ETEV + KKKEP+KRAA KKK TAKS Q S DSDD DFEI EI PPA KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Query: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
GGRKAAANAKTTK KK+EP+ +LGQKL+TQMLEP ENS IS EKKVRKIR SPFNKKSGS LGR +G EEE EE GNEGKM+ S
Subjt: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
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| TrEMBL top hits | e value | %identity | Alignment |
|---|
| A0A6J1DGT3 DNA topoisomerase 2 | 2.7e-118 | 67.25 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
EI+V NRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGA +ETDE E+ E KGERVSDY YLL +AIGTL I+KVQELCN+RD+LK EVEDL+KATPKSL
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
Query: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
WL DLD+ EKELDEMDRNDAQAEE+R++QRIK NN+ KPKISRN APKAP SNAVVKPKGKAAPRKA AKK +
Subjt: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
Query: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRGVP
VVN + +++DDEVLELKDRLAAYKIDSSPDR E +ETEV + KKKEP+KRA KKK TAKS Q + DSDD DFEI E+ PPA KK
Subjt: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRGVP
Query: PTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
GG + AANAKTTK PAAAKKRE KLGQKL+TQML P +N+ IS EKKVRK+RASPFNKKSGS LGRVG EEEEEG GNEGK++ S
Subjt: PTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
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| A0A6J1DIB5 DNA topoisomerase 2 | 3.0e-117 | 67.17 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
EI+V NRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGA +ETDE E+ E KGERVSDY YLL +AIGTL I+KVQELCN+RD+LK EVEDL+KATPKSL
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKSL
Query: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
WL DLD+ EKELDEMDRNDAQAEE+R++QRIK NN+ KPKISRN APKAP SNAVVKPKGKAAPRKA AKK +
Subjt: WLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRN-APKAP---------------------------PSNAVVKPKGKAAPRKALAKKPQ
Query: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRG
VVN + +++DDEVLELKDRLAAYKIDSSPDR EV +ETEV + KKKEP+KRA KKK TAKS Q + DSDD DFEI E+ PPA KK
Subjt: DKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ---SFDSDDKDFEINEIVPPATKKVRG
Query: VPPTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
GG + AANAKTTK PAAAKKRE KLGQKL+TQML P +N+ IS EKKVRK+RASPFNKKSGS LGRVG EEEEEG GNEGK++ S
Subjt: VPPTTKKVRGGRKAAANAKTTKVPAAAKKREPME-KLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEG---GNEGKMLCS
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| A0A6J1F9E0 DNA topoisomerase 2 | 5.3e-114 | 67.25 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
EIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGA +ETDE E+ E VKGERVSDYEYLL +AIGTL I+KVQELCNERDK K EVE+L+KATPKS
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
Query: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
LWL DLD EKELDEMDRNDAQA+E+R++QRIK NN+ KPKISRNAPKAP +N VVKPKGKAAPRKA AKK
Subjt: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Q K V++D ++DDEVLELKDRLAAYK++SSP+ EV +ETEV + KKKEP+KRAA KKK TAKS Q S DSDD DFEI EI PPA KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Query: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
GGRKAAANAKTTK KK+EP+ +LGQKL+TQMLEP ENS IS EKKVRKIR SPFNKKSGS LGR +G EEE EE GNEGKM+ S
Subjt: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
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| A0A6J1IWX9 DNA topoisomerase 2 | 8.2e-115 | 67.76 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
EIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGA +ETDE E+ E VKGERVSDYEYLL +AIGTL I+KVQELCNERDK K EVE+L+KATPKS
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
Query: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
LWL DLD EKELDEMDRNDAQA+E+R++QRIK NN+ KPKISRNAPKAP +N VVKPKGKAAPRKA AKK
Subjt: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Q KA V++D G DDEVLELKDRLAAYK++SSP+ EV +ETEV + KKKEP+KRAA KKK TAKS Q S DSDD DFEI EI PPA KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Query: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
GGRKAAANAKTTK KK+EP+ +LGQKL+TQMLEP ENS IS EKKVRKIR SPFNKKSGS LGR +G EEE EE GNEGKM+ S
Subjt: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
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| A0A6J1J555 DNA topoisomerase 2 | 4.1e-114 | 67.51 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
EIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGA +ETDE E+ E VKGERVSDYEYLL +AIGTL I+KVQELCNERDK K EVE+L+KATPKS
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE-VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPKS
Query: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
LWL DLD EKELDEMDRNDAQA+E+R++QRIK NN+ KPKISRNAPKAP +N VVKPKGKAAPRKA AKK
Subjt: LWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAP----------------------------PSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
KA V++D G DDEVLELKDRLAAYK++SSP+ EV +ETEV + KKKEP+KRAA KKK TAKS Q S DSDD DFEI EI PPA KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEV--IETEV-----STKKKEPNKRAATKKKITAKSTQ-SFDSDDKDFEINEIVPPATKKVRGV
Query: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
GGRKAAANAKTTK KK+EP+ +LGQKL+TQMLEP ENS IS EKKVRKIR SPFNKKSGS LGR +G EEE EE GNEGKM+ S
Subjt: PPTTKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGR-VGLEEE--EEGGNEGKMLCS
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| SwissProt top hits | e value | %identity | Alignment |
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| O24308 DNA topoisomerase 2 | 1.9e-47 | 38.21 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE---------VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVED
EIIV NR++ +L EL+ KGFTP P+K KS +P+VAGA D+ E ++ +E V+G DY+ LL + IGTL ++ VQ+L +E+ + ++E E
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDETDETEDISE---------VKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVED
Query: LKKATPKSLWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENN-------EEKPKISRNAPKA---PPSN-----------------AVVKPKGKAAPR
L SLWL DLD FEK+LDE+D A+ + R Q K+ N ++ P+ +N KA P N V KPKG+AAP+
Subjt: LKKATPKSLWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENN-------EEKPKISRNAPKA---PPSN-----------------AVVKPKGKAAPR
Query: KALAKKPQDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETE----VSTKKKEPNKRAATKKKITA--------KSTQSFDSDDKDF-EINE
K + K+P +D++ L++RLAAY I+SS ++ + +E+E + KK+ NKR KKK + D DD DF E+ +
Subjt: KALAKKPQDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETE----VSTKKKEPNKRAATKKKITA--------KSTQSFDSDDKDF-EINE
Query: IVPPATKKVRGVPPTTKKVRGGRK-AAANAK------TTKVPAAAKKRE--PMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGL
P K GGRK AA NAK K PAA KKR + GQKLLT ML+PAE + S EKKVRK+R SPFNKKSGS LGR
Subjt: IVPPATKKVRGVPPTTKKVRGGRK-AAANAK------TTKVPAAAKKRE--PMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGL
Query: EEE
++
Subjt: EEE
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| P08096 DNA topoisomerase 2 | 4.5e-09 | 25.99 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPF--PKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPK
E++V +++ DL EL+ K F P PKK V+ EV A E +++ D+S+ E Y YLL M + +L ++ EL ++D++ E++ L K TPK
Subjt: EIIVGNRRRVDLFHELQAKGFTPF--PKKTKSVEPEVAGAFDETDETEDISEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPK
Query: SLWLNDLDSFE----KELDEMDRNDAQAEE--------LRRRQRIKENNEEKPK--ISRNAPKAPPSNAVVKPKGKAAPRKA------LAKKPQDKAVVV
LWL+DLD+FE K +D++ R + E+ +++ R K KP+ ++ A A + K RK A K +K+ +
Subjt: SLWLNDLDSFE----KELDEMDRNDAQAEE--------LRRRQRIKENNEEKPK--ISRNAPKAPPSNAVVKPKGKAAPRKA------LAKKPQDKAVVV
Query: NDYGEEEDDEVLELKDRLAAYK--IDSSPD-----RLEVIETEVSTKKKEPNKRAAT-----KKKITAKSTQSFDSDDKDFEINEIVPPATKKVRGVPPT
N E++ L +++ + +DSS R + +++E + KK K AA+ +K +T F SDD+D +++P + K
Subjt: NDYGEEEDDEVLELKDRLAAYK--IDSSPD-----RLEVIETEVSTKKKEPNKRAAT-----KKKITAKSTQSFDSDDKDFEINEIVPPATKKVRGVPPT
Query: TKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKK
G+KA++ K + P K + EP E+S+ K+
Subjt: TKKVRGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKK
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| P30182 DNA topoisomerase 2 | 1.1e-34 | 34.63 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDE--TDETEDI--------SEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVE
EIIV R++ D+ +L+ KGFTPFP+K +SVE +AGA D+ +E E+I S + G S+Y+YLL MAI +L I+KV+EL +RDK+ V
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGAFDE--TDETEDI--------SEVKGERVSDYEYLLGMAIGTLIIDKVQELCNERDKLKREVE
Query: DLKKATPKSLWLNDLDSFEKELDEMDRNDAQAEEL--RRRQRIKENNEEKPKISRNAPKAPPSNAVVKPKGKAAPRKALAKKPQDKAVVVNDYGEEEDDE
D+KK TPKSLWL+DL+S +KEL+++D DAQ ++ +++I+ + K+ R APK P AP+K K + + + + D+
Subjt: DLKKATPKSLWLNDLDSFEKELDEMDRNDAQAEEL--RRRQRIKENNEEKPKISRNAPKAPPSNAVVKPKGKAAPRKALAKKPQDKAVVVNDYGEEEDDE
Query: VLEL---KDRLAAYKIDSSPDRLEVIETEVSTKKK-----EPNKRAATKKKITAKSTQSFDSDDKDF-----EINEIVPPA-------TKKVRGVPPTTK
V E+ K R A K S + E + + T +P R KKK A + + + + D + N PA T K V
Subjt: VLEL---KDRLAAYKIDSSPDRLEVIETEVSTKKK-----EPNKRAATKKKITAKSTQSFDSDDKDF-----EINEIVPPA-------TKKVRGVPPTTK
Query: KV--------RGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEE
V +GGRK AA K K PAA +KR ++L +S EKKVRK+R+SPFNKKS S + R+ +EEE
Subjt: KV--------RGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAENSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEE
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| P87078 DNA topoisomerase 2 | 9.9e-09 | 24.28 | Show/hide |
Query: MKEEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVE-PEVAGAFDETDETEDISEVKGER-------------------------VSDYEYLLGMAIGTLI
+++++ V N+++ L L+ FT F K K ++ E D+ DE E+ E +G+ S Y+YLLGMAI +L
Subjt: MKEEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVE-PEVAGAFDETDETEDISEVKGER-------------------------VSDYEYLLGMAIGTLI
Query: IDKVQELCNERDKLKREVEDLKKATPKSLWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAPPSNAVVKPKGKAAPRKALAKKP
++ + +RD+ + E+ L + K LW DLD F E D+ D Q E K++ + + K + A K P+N VK + K +K+ + KP
Subjt: IDKVQELCNERDKLKREVEDLKKATPKSLWLNDLDSFEKELDEMDRNDAQAEELRRRQRIKENNEEKPKISRNAPKAPPSNAVVKPKGKAAPRKALAKKP
Query: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETEVSTKKKEPNKRAATKKKITAKSTQSFDSDDKD-FEINEIVPPATKKVRGVPPTTKKV
K N+ + E D L+ + SS + K +P+ RA + K+I + S D DD+D F +N KK
Subjt: QDKAVVVNDYGEEEDDEVLELKDRLAAYKIDSSPDRLEVIETEVSTKKKEPNKRAATKKKITAKSTQSFDSDDKD-FEINEIVPPATKKVRGVPPTTKKV
Query: RGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAE--NSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEGGNE
AK+ AA+K + + G++ + LE E + E K R+ R + K + V ++ ++E +E
Subjt: RGGRKAAANAKTTKVPAAAKKREPMEKLGQKLLTQMLEPAE--NSNISSEKKVRKIRASPFNKKSGSTLGRVGLEEEEEGGNE
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| Q64511 DNA topoisomerase 2-beta | 2.7e-06 | 26.39 | Show/hide |
Query: EIIVGNRRRVDLFHELQAKGFTPFPKKT-KSVEPEVAGAFDETDETEDISEVKGERVS-DYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPK
+I + NR + DL L +G+ P K K + + A D ++ +D S G D+ Y+L M++ +L +KV+EL +RD REV DLK+ +P
Subjt: EIIVGNRRRVDLFHELQAKGFTPFPKKT-KSVEPEVAGAFDETDETEDISEVKGERVS-DYEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLKKATPK
Query: SLWLNDLDSFEKELDEM---DRNDAQAEELRRRQRIKENNEEKPKISRNAPKAPPSNAVVKPKGKA----APRKALAKK--PQDKAVVVNDYGEEEDDEV
LW DL +F +ELD++ +R D A + + K + K+ P + P+ A A RK L KK D VV ++ EE
Subjt: SLWLNDLDSFEKELDEM---DRNDAQAEELRRRQRIKENNEEKPKISRNAPKAPPSNAVVKPKGKA----APRKALAKK--PQDKAVVVNDYGEEEDDEV
Query: LE---LKDRLAAYKIDSSP-DRLEVIETEVSTKKKEPNKRAATKKKITAKSTQSFDSDDKDFEINEIVP
E + + ++ P + E E +K + KK+ ++ S D + ++ E P
Subjt: LE---LKDRLAAYKIDSSP-DRLEVIETEVSTKKKEPNKRAATKKKITAKSTQSFDSDDKDFEINEIVP
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