CuGenDBv2

Gene ID	Tan0004448
Organism	Trichosanthes anguina (Snake gourd v1)
Description	DNA topoisomerase
Genome location	LG08:56527731..56635665
RNA-Seq Expression	Tan0004448
Synteny	Tan0004448
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0005634 - nucleus (cellular component) GO:0005694 - chromosome (cellular component) GO:0003677 - DNA binding (molecular function) GO:0008270 - zinc ion binding (molecular function) GO:0003917 - DNA topoisomerase type I activity (molecular function)
InterPro domains	IPR003602 - DNA topoisomerase, type IA, DNA-binding domain IPR036875 - Zinc finger, CCHC-type superfamily IPR034144 - DNA topoisomerase 3-like, TOPRIM domain IPR023406 - DNA topoisomerase, type IA, active site IPR023405 - DNA topoisomerase, type IA, core domain IPR013826 - DNA topoisomerase, type IA, central region, subdomain 3 IPR013824 - DNA topoisomerase, type IA, central region, subdomain 1 IPR013497 - DNA topoisomerase, type IA, central IPR010666 - Zinc finger, GRF-type IPR006171 - TOPRIM domain IPR003601 - DNA topoisomerase, type IA, domain 2 IPR001878 - Zinc finger, CCHC-type IPR000380 - DNA topoisomerase, type IA

Homology

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GenBank top hits

e value

%identity

Alignment

XP_008443145.1 PREDICTED: DNA topoisomerase 3-alpha isoform X1 [Cucumis melo]

0.0e+00

88.5

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Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKW+SCDP +LFHAPV KFVPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSVTDD+N++LSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTF+WTRGNLFDYTCAV+ YEMCVQESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IV+EQQEHQIWGAYAQRLLDP SGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PT+LGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLA+ LQQMK+C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+ CGLCQ+SDMVLKRNR             CRNVVWLPGSIAEA VTSD C  CTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSR+SARGRGTSSSNVQR N GQSVCIFCQQVGHSSNDCPSQ VGS SAR  QSGESSVSCS+C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGR--------GHGQIAATFVSATGEPIS
        GTPCVLRTANT NNRGRKFYKCQSQECNFF+WEDNVDN NGG++A RSNVRSSGSA SNPNPG+N GRGRGR R        G GQIAATFVSATGEPIS
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGR--------GHGQIAATFVSATGEPIS

Query:  DRRCFVCGDPSHFANVCPNRGA
        DRRCFVCGDPSHFANVCPNRGA
Subjt:  DRRCFVCGDPSHFANVCPNRGA

XP_022154286.1 DNA topoisomerase 3-alpha [Momordica charantia]

0.0e+00

89.84

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Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGRPITVLNVAEKPSVAK+VATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPA+LFHAPVRKFVPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVV+VCTAVN HL IKRAHFSALIERDIHEAVQNLVQPN+WFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAF IDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTF+WTRG+LFDYTCAV+LYEMCVQESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FSQRTDLH IVQEQQ HQIWGAYAQRLLDPGSGLWRNPS GGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHH++YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGYKLWKP+LRAVMEHEMKAVSEGTKRK EVLA SLQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDARLNKLKLLEAMEVFFERSNGSGGDE+H VG VVRRCGLCQDSDMVLKRNR             CRNVVWLPGSIAEAAVT DCCNSCTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRG-TSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCST
        FKFR LEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMS RGRG TSSS+ QRGNTGQ VCI CQQVGHSSNDCPSQVVGSRSAR  QSGESSVSCS 
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRG-TSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCST

Query:  CGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVC
        CGTPCVLRTANTANNRGRKFY CQSQ+CNFF+WEDN+D+GNGG++APRSN+R S S ASNPNPG+N G GRGRGRG+  IA TFVSATGEPISDRRCFVC
Subjt:  CGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVC

Query:  GDPSHFANVCPNRGA
        GDPSHFANVCPNRGA
Subjt:  GDPSHFANVCPNRGA

XP_022982837.1 DNA topoisomerase 3-alpha isoform X1 [Cucurbita maxima]

0.0e+00

89.19

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Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        M+GGRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDP ELF+APVRK VPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCT VN HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NV+LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+LYEMCV+ESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGYKLWKPHLRA+MEHEMKAVSEG KRKDEVLAT LQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR NK KL EAMEVFFERSNGSGGDENHAVGEVV+RC LCQDSDMVLKRNR             CRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYN NHLGCIGGCDDILRQLTEICGTGSR+SARGRGTSSS+VQRGNT QSVC+FCQQ+ HSSNDCPSQVVGSRSAR  Q+GESS SCS C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGR--GRGRGHGQIAATFVSATGEPISDRRCFV
        GTPCVLRTANT NNRGRKFYKCQSQECNFF WED+VD+ NGG++A +SN+RSS SAASN NPGRN GRGR  G+G+G GQIAATFVSATGEPISDRRCFV
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGR--GRGRGHGQIAATFVSATGEPISDRRCFV

Query:  CGDPSHFANVCPNRGA
        CGDPSHFANVCPNRGA
Subjt:  CGDPSHFANVCPNRGA

XP_038904101.1 DNA topoisomerase 3-alpha isoform X1 [Benincasa hispida]

0.0e+00

89.82

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Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMELEFEERYRKWHSCDP +LFHAPVRK VPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWL+LWLDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSV DD+N++LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+ YEMCVQE TATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLAT LQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+RCGLCQDS+MVLKRNR             CRNVVWLPGSIAEAAVTSDCCN CTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSR+SARGRGTSSS+VQR NT QSVCIFCQQVGHSSNDCPSQVVGSRSA   QSGE SVSCS C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCG
        GTPCVLRTANT NNRGRKFYKCQSQECNFF+WEDNVDN NGG++A RSN+R+SGSAA NPNPGRN   GRGRGRG  +IAATFVSATGEPISDRRCFVCG
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCG

Query:  DPSHFANVCPNRGA
        D SHFANVCPNRGA
Subjt:  DPSHFANVCPNRGA

XP_038904102.1 DNA topoisomerase 3-alpha isoform X2 [Benincasa hispida]

0.0e+00

92.35

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Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMELEFEERYRKWHSCDP +LFHAPVRK VPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWL+LWLDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSV DD+N++LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+ YEMCVQE TATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDH
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDH
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDH

Query:  IKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGS
        IKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLAT LQQMK CFLDAR+NK KLLEAMEVFFERSNGS
Subjt:  IKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGS

Query:  GGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDD
        GGDEN AVGEVV+RCGLCQDS+MVLKRNR             CRNVVWLPGSIAEAAVTSDCCN CTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDD
Subjt:  GGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQLEIPPNYNANHLGCIGGCDD

Query:  ILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQ
        ILRQLTEICGTGSR+SARGRGTSSS+VQR NT QSVCIFCQQVGHSSNDCPSQVVGSRSA   QSGE SVSCS CGTPCVLRTANT NNRGRKFYKCQSQ
Subjt:  ILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKCQSQ

Query:  ECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCGDPSHFANVCPNRGA
        ECNFF+WEDNVDN NGG++A RSN+R+SGSAA NPNPGRN   GRGRGRG  +IAATFVSATGEPISDRRCFVCGD SHFANVCPNRGA
Subjt:  ECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCGDPSHFANVCPNRGA

TrEMBL top hits

e value

%identity

Alignment

A0A0A0LBG7 DNA topoisomerase

0.0e+00

88.2

Show/hide

Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGR ITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKWHSCDP +LFHAPV KFVPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQE+RR QWLVLWLDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIH+AVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSVTDD+N++LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTF+WTRGNLFDYTCAV+ YEMCVQESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IV+EQQEHQIWGAYAQRLLDP S LWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGY LWKP+LRA+MEHEMKAVSEGTKRKDEVLA+ LQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+ CGLCQDSDMVLKRNR             CRNVVWLPGSIAEA VTSD C  CTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSR+SARGRGTSSSNVQR N GQSVCIFCQQVGHSSNDCPSQ VGSRSA+  QSGESSVSCS+C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRG----------RGHGQIAATFVSATGEP
        G+PCVLRTANTANNRGRKFYKCQSQECNFF+WEDNVDNGNGG++  RSNVRSSGSA SN NPG+N GRGRGRG          RG GQIAATFVSATGEP
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRG----------RGHGQIAATFVSATGEP

Query:  ISDRRCFVCGDPSHFANVCPNRGA
        ISDRRCFVCGDPSHFANVCPNRGA
Subjt:  ISDRRCFVCGDPSHFANVCPNRGA

A0A1S3B7B9 DNA topoisomerase

0.0e+00

88.5

Show/hide

Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNM+VTSVTGHLMEL FEERYRKW+SCDP +LFHAPV KFVPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        +DIKRTLEQEARR QWLVLWLDCDREGENIAFEVVEVCTAVN HLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQT+LL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSVTDD+N++LSYGPCQFPTLGFVVERYWEIQ+HEPEEFWTINCSHNSDDGISTF+WTRGNLFDYTCAV+ YEMCVQESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IV+EQQEHQIWGAYAQRLLDP SGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PT+LGEALVMGYDDMGY LWKPHLRA+MEHEMKAVSEGTKRKDEVLA+ LQQMK+C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR+NK KLLEAMEVFFERSNGSGGDEN AVGEVV+ CGLCQ+SDMVLKRNR             CRNVVWLPGSIAEA VTSD C  CTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYNANHLGC+GGCDDILRQLTEICGTGSR+SARGRGTSSSNVQR N GQSVCIFCQQVGHSSNDCPSQ VGS SAR  QSGESSVSCS+C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGR--------GHGQIAATFVSATGEPIS
        GTPCVLRTANT NNRGRKFYKCQSQECNFF+WEDNVDN NGG++A RSNVRSSGSA SNPNPG+N GRGRGR R        G GQIAATFVSATGEPIS
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGR--------GHGQIAATFVSATGEPIS

Query:  DRRCFVCGDPSHFANVCPNRGA
        DRRCFVCGDPSHFANVCPNRGA
Subjt:  DRRCFVCGDPSHFANVCPNRGA

A0A6J1DNA0 DNA topoisomerase

0.0e+00

89.84

Show/hide

Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        MSGGRPITVLNVAEKPSVAK+VATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPA+LFHAPVRKFVPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVV+VCTAVN HL IKRAHFSALIERDIHEAVQNLVQPN+WFADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAF IDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTF+WTRG+LFDYTCAV+LYEMCVQESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETD FSQRTDLH IVQEQQ HQIWGAYAQRLLDPGSGLWRNPS GGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHH++YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGYKLWKP+LRAVMEHEMKAVSEGTKRK EVLA SLQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDARLNKLKLLEAMEVFFERSNGSGGDE+H VG VVRRCGLCQDSDMVLKRNR             CRNVVWLPGSIAEAAVT DCCNSCTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRG-TSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCST
        FKFR LEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMS RGRG TSSS+ QRGNTGQ VCI CQQVGHSSNDCPSQVVGSRSAR  QSGESSVSCS 
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRG-TSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCST

Query:  CGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVC
        CGTPCVLRTANTANNRGRKFY CQSQ+CNFF+WEDN+D+GNGG++APRSN+R S S ASNPNPG+N G GRGRGRG+  IA TFVSATGEPISDRRCFVC
Subjt:  CGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVC

Query:  GDPSHFANVCPNRGA
        GDPSHFANVCPNRGA
Subjt:  GDPSHFANVCPNRGA

A0A6J1F0T9 DNA topoisomerase

0.0e+00

89.08

Show/hide

Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        M+GGRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDP ELF+APVRK VPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEA RCQWLVLWLDCDREGENIAFEVVEVCT VN HLNIKRAHFSALIERDIHEAVQNLVQPNK++ADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NV+LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+LYEMCV+ESTATVVNV+RQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGYKLWKPHLRA+MEHEMKAVSEG KRKDEVLAT LQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR NK KL EAMEVFFERSNGSGGDENHAVGEVV+RC LCQDSDMVLKRNR             CRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYN NHLGCIGGCDDILRQLTEICGTGSR+SARGRGTSSS+VQRGNT QSVC+FCQQ+ HSSNDCPSQVVGSRSAR  Q+GESS SCS C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGR--GRGHGQIAATFVSATGEPISDRRCFV
        GTPCVLRTANT NNRGRKFYKCQSQECNFF WED+VD+ NGG++A RSN+RSSGSAASN NPGRN GRGRGR  G+G GQIAATFVSA GEPISDRRCFV
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGR--GRGHGQIAATFVSATGEPISDRRCFV

Query:  CGDPSHFANVCPNRGA
        CGDPSHFANVCPNRGA
Subjt:  CGDPSHFANVCPNRGA

A0A6J1IXM8 DNA topoisomerase

0.0e+00

89.19

Show/hide

Query:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK
        M+GGRPITVLNVAEKPSVAKSVATILSRNQGLRVR+GRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDP ELF+APVRK VPEDK
Subjt:  MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDK

Query:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL
        MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCT VN HLNIKRAHFSALIERDIHEAVQNLVQPNK+FADAVDARQEIDLRIGASFTRFQTMLL
Subjt:  MDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLL

Query:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY
        KDAFNIDSV DD+NV+LSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNS DGISTF+WTRGNLFDYTCAV+LYEMCV+ESTATVVNVRRQETLKY
Subjt:  KDAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKY

Query:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
        PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLH IVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP
Subjt:  PPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHP

Query:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP
        TKFSAGER WSQDHHR+YELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA                         FVPTTLTLDSGVTRPPP
Subjt:  TKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPP

Query:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC
        LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKD NTRF PTNLGEALVMGYDDMGYKLWKPHLRA+MEHEMKAVSEG KRKDEVLAT LQQMK C
Subjt:  LLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDC

Query:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ
        FLDAR NK KL EAMEVFFERSNGSGGDENHAVGEVV+RC LCQDSDMVLKRNR             CRNVVWLPGSIAEAAVTS+ CNSCTPGPVYLIQ
Subjt:  FLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQ

Query:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC
        FKFRQLEIPPNYN NHLGCIGGCDDILRQLTEICGTGSR+SARGRGTSSS+VQRGNT QSVC+FCQQ+ HSSNDCPSQVVGSRSAR  Q+GESS SCS C
Subjt:  FKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTC

Query:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGR--GRGRGHGQIAATFVSATGEPISDRRCFV
        GTPCVLRTANT NNRGRKFYKCQSQECNFF WED+VD+ NGG++A +SN+RSS SAASN NPGRN GRGR  G+G+G GQIAATFVSATGEPISDRRCFV
Subjt:  GTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGR--GRGRGHGQIAATFVSATGEPISDRRCFV

Query:  CGDPSHFANVCPNRGA
        CGDPSHFANVCPNRGA
Subjt:  CGDPSHFANVCPNRGA

SwissProt top hits

e value

%identity

Alignment

C7J0A2 DNA topoisomerase 3-alpha

0.0e+00

64.97

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Query:  GGRPITVLNVAEKPSVAKSVATILSR-NQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKM
        GG  I VLNVAEKPSVAKSVA ILSR + G+R R+GRSRYN++FEF+Y+I G++C+MLVTSVTGHLMELEF++R+R+WHSCDPA+LFHAPVRK VP+DK 
Subjt:  GGRPITVLNVAEKPSVAKSVATILSR-NQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKM

Query:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK
        DIKRTLE+EAR+CQWLVLWLDCDREGENIA+EV+++C   N  LNI RA FSALI+R+IHEAVQ+L +PNK FADAVDARQEIDLRIGASFTRFQTMLLK
Subjt:  DIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLK

Query:  DAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYP
        DAF +D   DD+N+ILSYGPCQFPTLGF+VER+WEIQ+HEPEEFWTINCSH SD+G ++F W RG+LFDY+ AV++YEMCV+E  ATV NVR QE LKYP
Subjt:  DAFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYP

Query:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT
        P+PL+TIEL+KRASRYFRMSSEHTMKVAE+LYQAGFISYPRTETD FS  TDLH+IV EQ  H  WG YAQRLLDP + LWRNPS GGHDDKAHPPIHPT
Subjt:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT

Query:  KFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPL
        KFSAGE  W+ +H ++YELVVRHFLAC SQPAVGA TTVEIDIAGE F+ SGR++LA                         FVPTTLTLDSG+TRPPPL
Subjt:  KFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPL

Query:  LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF
        L+EADLL CMDK GIGTDATMHDHIKKLLDR YATKD NTRF PTNLGEALVMGYD+MGY+LWKP+LR++ME +MK+VS GTK K EVL   LQQMK CF
Subjt:  LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF

Query:  LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRN-------------RCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQF
        LDAR NK+KL +AM  FF RS+    +  +++ E VR C  C +S+M LK+              +CRNVVWLP S++ AAVT   C +C PGPVY IQF
Subjt:  LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRN-------------RCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQF

Query:  KFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMS----ARGRGTSSSNVQRGNTGQSV-CIFCQQVGHSSNDCP-SQVVGSRSARCWQSGESS-
        KFR+ +IPPN++ +HLGCIGGCDDIL++L E+   GS       AR +  ++S V++G++ Q +   F   V  ++   P     G RS     SG +S 
Subjt:  KFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMS----ARGRGTSSSNVQRGNTGQSV-CIFCQQVGHSSNDCP-SQVVGSRSARCWQSGESS-

Query:  -VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDN----GNGGH-NAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATG
         V C++C  PCVLRTANT  NRGRKFYKCQ+  C FF WED+V+N    G GG     RS+ R S ++AS    G   GRGR RGRG       FV+ATG
Subjt:  -VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDN----GNGGH-NAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATG

Query:  EPISDRRCFVCGDPSHFANVCPNRG
        EP+    CF+CGDP+HFANVCPN G
Subjt:  EPISDRRCFVCGDPSHFANVCPNRG

O70157 DNA topoisomerase 3-alpha

1.4e-180

40.9

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Query:  VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLE
        VL VAEK   AK +A +LS N  +R ++G S++NKI+EF+Y + GQ+  M++TSV+GHL+  +F+ ++RKW SC+P  LF A + K+ PE+ +DIK+TLE
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLE

Query:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS
        +E   CQ LV+W DCDREGENI FE++ VC AV  +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRIGA+FTRFQT+ L+  F    
Subjt:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS

Query:  VTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTI
        V  ++  ++SYG CQFPTLGFVVER+  IQ+  PE F  I  +H+  DG   FNW R  LF++T  ++LY++C+++  ATVV VR +   K+ P  L+T+
Subjt:  VTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTI

Query:  ELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER
        ELEK ASR  R++++ TM++AE LY  G+ISYPRTET+ F +  +L A+V++Q     WGA+AQ +L+ G      P  G   D+AHPPIHPTK+++G  
Subjt:  ELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER

Query:  RWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPLLSEADLL
            D  R+YE +VRHFLAC SQ A G  TTVEIDIA E F   G +ILA                         F P+T+ +  G T PP LL+EADL+
Subjt:  RWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPLLSEADLL

Query:  SCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNK
        + M+K GIGTDAT  +HI+ +  R Y    ++ RF+P +LG  LV GYD MGY++ KP LRA +E ++K + EG K K +VL   +Q+ K  F++A    
Subjt:  SCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNK

Query:  LKLLEAMEVFF-ERSNGSGGDENH-AVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQL
         KL EA+  +  ER+  +  +E + A+ E VR+C  C + DMVLK  +             CR+ VW P S+ EA+  +  C+ C P PVY ++ KF++ 
Subjt:  LKLLEAMEVFF-ERSNGSGGDENH-AVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQL

Query:  EIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRG---NTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTP
         +PP      +GCIGGCD+ L+   EI G     +       S ++Q     N   S      Q   + +  PS+ V         +GES+     CG  
Subjt:  EIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRG---NTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTP

Query:  CVLRTANTAN-NRGRKFYKCQSQECNFFIWEDNVDNGNGG-----HNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRG--HGQIAATFVSATGEPISDRR
         VL T      N+GR FYKC + +CNFF+W D+  +  GG        P S+V    S  S+ +   ++G     G     GQ A T       P   R+
Subjt:  CVLRTANTAN-NRGRKFYKCQSQECNFFIWEDNVDNGNGG-----HNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRG--HGQIAATFVSATGEPISDRR

Query:  CFVCGDP
           C  P
Subjt:  CFVCGDP

Q13472 DNA topoisomerase 3-alpha

1.4e-183

42.12

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Query:  VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLE
        VL VAEK   AK +A +LS N  +R R+G S++NKI+EF+Y + GQ+  M++TSV+GHL+  +F+ ++RKW SC+P  LF A + K+ PE+ +DIK+TLE
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLE

Query:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS
        +E R+CQ LV+W DCDREGENI FE++ VC AV  +L + RA FS +    +  A +NL +P++  +DAVD RQE+DLRIGA+FTRFQT+ L+  F    
Subjt:  QEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDS

Query:  VTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTI
        V  ++  ++SYG CQFPTLGFVVER+  IQ+  PE F  I  +H+  DGI  FNW R  LF++T  ++LY++CV++  ATVV VR +   K+ P  L+T+
Subjt:  VTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTI

Query:  ELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER
        ELEK ASR  R++++ TM++AE LY  G+ISYPRTET+ F +  +L  +V++Q     WGA+AQ +L+ G      P  G   D+AHPPIHPTK++    
Subjt:  ELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGER

Query:  RWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPLLSEADLL
            D  R+YE +VRHFLAC SQ A G  TTVEIDIA E F   G MILA                         F P+T+ +  G T PP LL+EADL+
Subjt:  RWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPLLSEADLL

Query:  SCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNK
        + M+K GIGTDAT  +HI+ +  R Y     + RF+P +LG  LV GYD MGY++ KP LRA +E ++K + +G K K  VL   +Q+ K  F++A    
Subjt:  SCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNK

Query:  LKLLEAMEVFFERSNGSGGDEN--HAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQL
         KL EA+  +F         E+   A+ E +R+C  C + DMVLK  +             CR+ VWLP S+ EA+  S  C  C P PVY ++ KF++ 
Subjt:  LKLLEAMEVFFERSNGSGGDEN--HAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQFKFRQL

Query:  EIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSA---RGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTP
         +PP      + CIGGCDD LR++ ++  +G    A    GR  ++ ++ R +  Q       Q   S     S+ +         +GES+     CG  
Subjt:  EIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSA---RGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTP

Query:  CVLRTANTAN-NRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSG-SAASNPNPGRNIGRGRGRGRGHG
         VL T      NRGR+F+KC    CNFF+W D+ + G GG   P    R  G S    P PG ++G     G G G
Subjt:  CVLRTANTAN-NRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSG-SAASNPNPGRNIGRGRGRGRGHG

Q8T2T7 DNA topoisomerase 3

1.1e-151

44.8

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Query:  VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTL
        +LNVAEKPS AK +A ILS N+   VR+G S+YNK+++F Y I     C M  TSVTGHLME++  E+++ W SCDP +LF AP+RK VP DK  +K+TL
Subjt:  VLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRG-QSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTL

Query:  EQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNID
        E+E ++   L+LWLDCDREGENIAFEV+EVC          RAHFSA+I R+I  A +NL +PN+  + AVD R EIDLRIGA+FTRFQT+ LK  F I 
Subjt:  EQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNID

Query:  SVTDDK---------------------NVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFNWTRGNLFDYTCAVLLYEM
        S +D++                       I+SYGPCQFPTLGFVVERY+ I + +PE+FW ++  H   D  S      TF+W R  LFDYT A +LYE 
Subjt:  SVTDDK---------------------NVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGIS------TFNWTRGNLFDYTCAVLLYEM

Query:  CVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSG
        C+  + ATVV+V  +E+ +Y P PL TIEL+K AS+  R+SS  TM+ AE+LY  G ISYPRTETD F   TDL  ++  Q  +  WGAYA RL++    
Subjt:  CVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSG

Query:  LWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMIL-----------------------
        ++  P  G ++D +HPPIHPT  + G    S +  ++Y+ + R FLAC S+ +V A TTV IDI GE FS +G M+L                       
Subjt:  LWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMIL-----------------------

Query:  --AFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVS
           F P  + L  G T  P  ++EA+LL+ MD   IGTDATM  HI+ + DRFY  K+ + +F+P+NLG +LV  Y+ MG++  KP+LRA +E ++  +S
Subjt:  --AFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVS

Query:  EGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC
         G K K EVL +++++ K  +  A  N      +   ++E ++  GG+    V +   RCG C
Subjt:  EGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC

Q9LVP1 DNA topoisomerase 3-alpha

0.0e+00

67.68

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Query:  GGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMD
        GG P+TVLNVAEKPSVAKSVA ILSR    R R+GRSRYNKIFEF+YAI GQ C ML+TSV GHLMELEF +RYRKWHSCDPA+L+ APV K VPEDK D
Subjt:  GGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMD

Query:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD
        IK+TLE+EAR+  WLVLWLDCDREGENIAFEVV+VC AV  +L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQEIDLRIGASFTRFQTMLL+D
Subjt:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD

Query:  AFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNV-RRQETLKYP
         F IDS  ++++ ++SYGPCQFPTLGF+VERYWEIQ+HEPEEFWTINCSH S++G++TFNW RG+LFDY  AV+LYEMCV+E TATV+NV   +E  KYP
Subjt:  AFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNV-RRQETLKYP

Query:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT
        P+PLNTIELEKRASRYFR+SSEHTMKVAE+LYQAGFISYPRTETD FS RTDL A+V+EQ  H  WG+YAQRLL+P  GLWRNP+ GGHDDKAHPPIHPT
Subjt:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT

Query:  KFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPL
        KFS+GE  WS+DH  VYELVVRH+LACVSQPAV A TTVEIDIAGE FS SGR ILA                         F+PTTLTLD+ VTRPPPL
Subjt:  KFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPL

Query:  LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF
        L EADLLSCMDK GIGTDATMHDHIKKLLDR YATKD NTRF PTNLGEALVMGYDDMGY+LWKP+LRA+MEH+M  VS G K K EVL T LQQMK CF
Subjt:  LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF

Query:  LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQF
        LDAR+ K KLLEAM +FFERSN +   E+   GEVVRRC LC +SDM L++NR             CRN VWLPG   EA+VT++ C SC PGPVY I F
Subjt:  LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQF

Query:  KFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGR-GTS-SSNVQRGNTGQS-VCIFCQQVGHSSNDCPSQVVGSRSARCW----QSGESS
        KFRQ+ IPP ++ NHLGC+GGCDDIL+QL +ICGTGSR  AR   GT+ S+N+Q  NT QS VCI CQQ GH+S +CPS+V  SR++R      ++ ES+
Subjt:  KFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGR-GTS-SSNVQRGNTGQS-VCIFCQQVGHSSNDCPSQVVGSRSARCW----QSGESS

Query:  VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIA-------ATFVSAT
        VSC+TCG+ CVLRTANT  NRGR+F+ C +Q C+FF WED+++N +G          ++ + +++   GR   RGRGRG   GQ +        +FVSAT
Subjt:  VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIA-------ATFVSAT

Query:  GEPISDRRCFVCGDPSHFANVCPNR
        GEP+S  RCF CGDPSHFAN CPNR
Subjt:  GEPISDRRCFVCGDPSHFANVCPNR

Arabidopsis top hits

e value

%identity

Alignment

AT2G32000.1 DNA topoisomerase, type IA, core

5.0e-104

36.41

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Query:  ITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRT
        + VL VAEKPS+A S+A++LS  Q +  R G +   ++ EF+   RG   +  VTSV GH+  ++F E+Y+ W + DP +LF AP+ K     K  I R 
Subjt:  ITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRT

Query:  LEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF
        L  EAR C ++VLWLDCDREGENI FEV+E       +    + RA FS++ E+DI +A+ NLV+PN+  A AVDARQEIDL++G +F+RFQT   +  +
Subjt:  LEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF

Query:  -NIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPH
         N+D        ++SYGPCQ PTLGF V+RY  I + +PE+FW +      D       W R  LFD   A +  ++ V+  TA V++V  ++ +K  P 
Subjt:  -NIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPH

Query:  PLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKF
         LNT+ L K AS       +  M +AE LY  GFISYPRTE+  +    D    ++ Q  + +WG Y QRLL  G  + ++    G D   HPPI P + 
Subjt:  PLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKF

Query:  SAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMI-----LAFVPTT--------------------LTLDSGVTRPPPLLS
        +A E     D  R+Y+ V +HFL  VS       T VE+ I GE F  +G+ +      A +P +                    + L  G T PP  L+
Subjt:  SAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMI-----LAFVPTT--------------------LTLDSGVTRPPPLLS

Query:  EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLD
        E++L+S M+K GIGTDA++  HI  + +R Y    +  + +PT LG  L+ GY  +   L  P +R+ +E ++  V++G      V+   +QQ +  F  
Subjt:  EADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLD

Query:  ARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC
             ++ +E M+  FE       D     G  + +CG C
Subjt:  ARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC

AT2G32000.2 DNA topoisomerase, type IA, core

3.4e-92

35.86

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Query:  LMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TAVNCHLNIKRAHFSALIERDIHEAV
        +M  +F E+Y+ W + DP +LF AP+ K     K  I R L  EAR C ++VLWLDCDREGENI FEV+E       +    + RA FS++ E+DI +A+
Subjt:  LMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVC--TAVNCHLNIKRAHFSALIERDIHEAV

Query:  QNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF-NIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNW
         NLV+PN+  A AVDARQEIDL++G +F+RFQT   +  + N+D        ++SYGPCQ PTLGF V+RY  I + +PE+FW +      D       W
Subjt:  QNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAF-NIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNW

Query:  TRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQE
         R  LFD   A +  ++ V+  TA V++V  ++ +K  P  LNT+ L K AS       +  M +AE LY  GFISYPRTE+  +    D    ++ Q  
Subjt:  TRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQE

Query:  HQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMI-----LA
        + +WG Y QRLL  G  + ++    G D   HPPI P + +A E     D  R+Y+ V +HFL  VS       T VE+ I GE F  +G+ +      A
Subjt:  HQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMI-----LA

Query:  FVPTT--------------------LTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKL
         +P +                    + L  G T PP  L+E++L+S M+K GIGTDA++  HI  + +R Y    +  + +PT LG  L+ GY  +   L
Subjt:  FVPTT--------------------LTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKL

Query:  WKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC
          P +R+ +E ++  V++G      V+   +QQ +  F       ++ +E M+  FE       D     G  + +CG C
Subjt:  WKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLC

AT4G31210.1 DNA topoisomerase, type IA, core

2.2e-14

24.72

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Query:  LVLWLDCDREGENIAFEVVEVCT---AVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDK
        L+L  D DREGE IA+ ++E+     A++  + + R  F  + E  I  A+Q+  + +     A  AR+ +D  IG              FNI  +   K
Subjt:  LVLWLDCDREGENIAFEVVEVCT---AVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDK

Query:  -NVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTF-------NWTRGNLFDYTCAVLL--YEMCVQESTATVVNVRRQETLKYPPH
             S G  Q   L  V +R  EI   +P+E+WT+       D  +TF       N  R N    +        E  ++     V   +   T K PP 
Subjt:  -NVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTF-------NWTRGNLFDYTCAVLL--YEMCVQESTATVVNVRRQETLKYPPH

Query:  PLNTIELEKRASRYFRMSSEHTMKVAEDLYQ---------AGFISYPRTETDCFSQRT--DLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDD
        P  T  L++ A+     S+ HTMK+A+ LY+         AG I+Y RT+    +     D+ ++V E+          ++                +  
Subjt:  PLNTIELEKRASRYFRMSSEHTMKVAEDLYQ---------AGFISYPRTETDCFSQRT--DLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDD

Query:  KAHPPIHPTKF----SAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDI
        +AH  I PT      S        D  ++Y L+    +AC  +PA  ++  +++DI
Subjt:  KAHPPIHPTKF----SAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDI

AT5G13920.1 GRF zinc finger / Zinc knuckle protein

3.4e-07

39.47

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Query:  CIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKC-QSQECNFFIWEDNV
        C  C+Q GH  NDCP +               ++ C   G  C ++ ANT  N GRKFYKC  +Q C FF W D V
Subjt:  CIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRTANTANNRGRKFYKC-QSQECNFFIWEDNV

AT5G63920.1 topoisomerase 3alpha

0.0e+00

67.68

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Query:  GGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMD
        GG P+TVLNVAEKPSVAKSVA ILSR    R R+GRSRYNKIFEF+YAI GQ C ML+TSV GHLMELEF +RYRKWHSCDPA+L+ APV K VPEDK D
Subjt:  GGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMD

Query:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD
        IK+TLE+EAR+  WLVLWLDCDREGENIAFEVV+VC AV  +L I+RAHFSALI+RDIHEAVQNL  PN+ FA+AVDARQEIDLRIGASFTRFQTMLL+D
Subjt:  IKRTLEQEARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKD

Query:  AFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNV-RRQETLKYP
         F IDS  ++++ ++SYGPCQFPTLGF+VERYWEIQ+HEPEEFWTINCSH S++G++TFNW RG+LFDY  AV+LYEMCV+E TATV+NV   +E  KYP
Subjt:  AFNIDSVTDDKNVILSYGPCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNV-RRQETLKYP

Query:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT
        P+PLNTIELEKRASRYFR+SSEHTMKVAE+LYQAGFISYPRTETD FS RTDL A+V+EQ  H  WG+YAQRLL+P  GLWRNP+ GGHDDKAHPPIHPT
Subjt:  PHPLNTIELEKRASRYFRMSSEHTMKVAEDLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPT

Query:  KFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPL
        KFS+GE  WS+DH  VYELVVRH+LACVSQPAV A TTVEIDIAGE FS SGR ILA                         F+PTTLTLD+ VTRPPPL
Subjt:  KFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTVEIDIAGELFSTSGRMILA-------------------------FVPTTLTLDSGVTRPPPL

Query:  LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF
        L EADLLSCMDK GIGTDATMHDHIKKLLDR YATKD NTRF PTNLGEALVMGYDDMGY+LWKP+LRA+MEH+M  VS G K K EVL T LQQMK CF
Subjt:  LSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHEMKAVSEGTKRKDEVLATSLQQMKDCF

Query:  LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQF
        LDAR+ K KLLEAM +FFERSN +   E+   GEVVRRC LC +SDM L++NR             CRN VWLPG   EA+VT++ C SC PGPVY I F
Subjt:  LDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNR-------------CRNVVWLPGSIAEAAVTSDCCNSCTPGPVYLIQF

Query:  KFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGR-GTS-SSNVQRGNTGQS-VCIFCQQVGHSSNDCPSQVVGSRSARCW----QSGESS
        KFRQ+ IPP ++ NHLGC+GGCDDIL+QL +ICGTGSR  AR   GT+ S+N+Q  NT QS VCI CQQ GH+S +CPS+V  SR++R      ++ ES+
Subjt:  KFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGR-GTS-SSNVQRGNTGQS-VCIFCQQVGHSSNDCPSQVVGSRSARCW----QSGESS

Query:  VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIA-------ATFVSAT
        VSC+TCG+ CVLRTANT  NRGR+F+ C +Q C+FF WED+++N +G          ++ + +++   GR   RGRGRG   GQ +        +FVSAT
Subjt:  VSCSTCGTPCVLRTANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIA-------ATFVSAT

Query:  GEPISDRRCFVCGDPSHFANVCPNR
        GEP+S  RCF CGDPSHFAN CPNR
Subjt:  GEPISDRRCFVCGDPSHFANVCPNR

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGTCCGGCGGCCGTCCGATCACCGTTCTCAATGTAGCAGAGAAGCCATCGGTGGCGAAATCTGTGGCCACCATACTCTCCAGGAACCAGGGCCTTCGAGTTCGCGACGG
TCGTTCTCGCTACAACAAGATTTTCGAGTTCAACTACGCCATTCGAGGCCAGTCTTGCAATATGCTCGTCACCTCCGTCACAGGTCATTTGATGGAGCTCGAGTTCGAAG
AACGGTACCGCAAATGGCATTCCTGTGACCCAGCCGAGCTTTTCCATGCTCCCGTCCGCAAATTTGTCCCCGAGGACAAGATGGATATAAAGAGGACATTGGAACAAGAA
GCTAGAAGGTGTCAATGGCTCGTCCTCTGGCTTGATTGTGATAGAGAAGGAGAAAATATTGCCTTTGAAGTCGTGGAAGTTTGCACAGCAGTGAATTGTCATCTTAACAT
TAAGAGGGCCCACTTCTCTGCTTTGATCGAAAGGGATATTCACGAAGCTGTGCAAAATCTTGTCCAACCAAATAAATGGTTTGCTGATGCGGTTGATGCTAGACAAGAAA
TTGATCTAAGAATTGGTGCTTCTTTTACTAGGTTCCAAACTATGCTGTTGAAAGATGCATTTAATATTGATTCTGTCACAGATGACAAAAATGTTATTTTGAGTTATGGG
CCTTGTCAGTTTCCTACTCTTGGTTTTGTTGTTGAGCGGTACTGGGAGATTCAATCCCATGAGCCAGAAGAATTTTGGACGATCAACTGTTCGCACAATTCTGATGATGG
AATTTCTACATTTAATTGGACGAGAGGGAATCTATTTGATTATACTTGTGCTGTTTTGCTCTATGAAATGTGTGTACAAGAATCGACTGCTACGGTTGTAAATGTTAGAC
GACAAGAGACGTTAAAGTATCCTCCTCATCCATTGAATACAATTGAACTTGAAAAACGAGCTTCACGGTACTTCCGAATGAGTTCTGAACACACTATGAAGGTGGCCGAA
GATCTGTACCAAGCAGGTTTCATTAGTTATCCTCGTACAGAGACTGATTGCTTTTCTCAAAGGACCGATCTTCATGCGATTGTGCAAGAACAACAAGAACACCAAATATG
GGGAGCCTATGCACAAAGGTTGCTGGATCCTGGATCAGGACTTTGGAGGAATCCTAGTGGTGGTGGCCATGATGACAAAGCCCATCCACCTATTCACCCAACGAAGTTCT
CTGCTGGGGAACGCAGATGGAGCCAAGATCATCATAGAGTGTATGAGCTAGTCGTTCGCCATTTTCTGGCATGTGTCTCACAGCCAGCTGTAGGTGCTGTGACCACTGTT
GAAATTGATATTGCTGGTGAATTGTTTTCTACATCTGGGAGAATGATACTAGCATTTGTTCCAACAACATTAACTCTTGATTCAGGAGTCACAAGACCACCTCCCCTTCT
GAGTGAAGCTGATTTGCTCTCTTGTATGGATAAGGAGGGAATTGGTACAGATGCAACAATGCATGACCACATCAAGAAGTTGCTGGATAGATTTTATGCAACAAAGGACA
CAAACACTCGTTTCATGCCAACTAACCTGGGTGAGGCTCTGGTTATGGGATATGACGACATGGGGTATAAACTGTGGAAACCTCACCTTAGAGCCGTCATGGAGCACGAG
ATGAAAGCAGTTAGTGAGGGCACTAAGAGAAAAGATGAAGTGTTGGCTACATCCTTGCAGCAGATGAAAGATTGCTTCTTAGATGCAAGGTTGAATAAGCTAAAACTTCT
TGAAGCCATGGAGGTTTTCTTTGAGAGATCTAATGGTTCTGGCGGGGATGAAAATCATGCAGTTGGAGAAGTTGTCCGTCGATGTGGACTGTGTCAGGACTCAGATATGG
TGCTTAAAAGAAACAGGTGTAGAAATGTTGTCTGGCTCCCAGGATCCATTGCAGAAGCAGCAGTAACCTCTGATTGTTGCAACTCGTGCACCCCAGGTCCTGTTTACTTG
ATCCAATTTAAGTTTCGTCAGCTGGAAATACCACCAAACTACAATGCTAACCACTTGGGTTGTATAGGTGGTTGCGATGATATTCTTCGGCAGTTGACAGAAATCTGTGG
TACTGGATCTCGCATGTCAGCTAGAGGTCGAGGAACTTCATCATCAAATGTGCAACGAGGTAACACCGGGCAAAGTGTATGCATTTTCTGCCAACAAGTAGGCCATTCCT
CAAACGATTGCCCTTCACAGGTTGTAGGTTCCAGAAGTGCTCGTTGTTGGCAAAGTGGGGAATCTTCAGTTTCATGTAGTACCTGTGGTACACCATGCGTCTTACGGACA
GCAAATACTGCCAATAATAGGGGAAGAAAATTCTACAAATGTCAATCTCAAGAGTGCAATTTTTTCATATGGGAAGACAACGTAGACAATGGCAATGGAGGACATAATGC
TCCACGGTCAAATGTCAGGAGCTCAGGCTCAGCGGCATCTAATCCAAACCCTGGTCGAAACATTGGGCGTGGTCGCGGTCGCGGTCGCGGTCACGGTCAGATTGCAGCAA
CATTCGTGTCTGCAACTGGTGAGCCAATATCTGATAGAAGATGTTTTGTTTGTGGTGATCCATCACACTTTGCAAATGTTTGCCCAAATCGTGGTGCTTGA

mRNA sequence

Show/hide mRNA sequence

Protein sequence

Show/hide protein sequence

MSGGRPITVLNVAEKPSVAKSVATILSRNQGLRVRDGRSRYNKIFEFNYAIRGQSCNMLVTSVTGHLMELEFEERYRKWHSCDPAELFHAPVRKFVPEDKMDIKRTLEQE
ARRCQWLVLWLDCDREGENIAFEVVEVCTAVNCHLNIKRAHFSALIERDIHEAVQNLVQPNKWFADAVDARQEIDLRIGASFTRFQTMLLKDAFNIDSVTDDKNVILSYG
PCQFPTLGFVVERYWEIQSHEPEEFWTINCSHNSDDGISTFNWTRGNLFDYTCAVLLYEMCVQESTATVVNVRRQETLKYPPHPLNTIELEKRASRYFRMSSEHTMKVAE
DLYQAGFISYPRTETDCFSQRTDLHAIVQEQQEHQIWGAYAQRLLDPGSGLWRNPSGGGHDDKAHPPIHPTKFSAGERRWSQDHHRVYELVVRHFLACVSQPAVGAVTTV
EIDIAGELFSTSGRMILAFVPTTLTLDSGVTRPPPLLSEADLLSCMDKEGIGTDATMHDHIKKLLDRFYATKDTNTRFMPTNLGEALVMGYDDMGYKLWKPHLRAVMEHE
MKAVSEGTKRKDEVLATSLQQMKDCFLDARLNKLKLLEAMEVFFERSNGSGGDENHAVGEVVRRCGLCQDSDMVLKRNRCRNVVWLPGSIAEAAVTSDCCNSCTPGPVYL
IQFKFRQLEIPPNYNANHLGCIGGCDDILRQLTEICGTGSRMSARGRGTSSSNVQRGNTGQSVCIFCQQVGHSSNDCPSQVVGSRSARCWQSGESSVSCSTCGTPCVLRT
ANTANNRGRKFYKCQSQECNFFIWEDNVDNGNGGHNAPRSNVRSSGSAASNPNPGRNIGRGRGRGRGHGQIAATFVSATGEPISDRRCFVCGDPSHFANVCPNRGA

Tan0004448 (gene) of Snake gourd v1 genome