CuGenDBv2

Gene ID	Tan0005124
Organism	Trichosanthes anguina (Snake gourd v1)
Description	DNA topoisomerase 2
Genome location	LG06:66475675..66487329
RNA-Seq Expression	Tan0005124
Synteny	Tan0005124
Gene Ontology terms	GO:0006265 - DNA topological change (biological process) GO:0043231 - intracellular membrane-bounded organelle (cellular component) GO:0003677 - DNA binding (molecular function) GO:0046872 - metal ion binding (molecular function) GO:0005524 - ATP binding (molecular function) GO:0003918 - DNA topoisomerase type II (ATP-hydrolyzing) activity (molecular function)
InterPro domains	IPR013506 - DNA topoisomerase, type IIA, subunit B, domain 2 IPR036890 - Histidine kinase/HSP90-like ATPase superfamily IPR034157 - DNA topoisomerase 2, TOPRIM domain IPR031660 - C-terminal associated domain of TOPRIM IPR020568 - Ribosomal protein S5 domain 2-type fold IPR018522 - DNA topoisomerase, type IIA, conserved site IPR014721 - Ribosomal protein S5 domain 2-type fold, subgroup IPR013760 - DNA topoisomerase, type IIA-like domain superfamily IPR013759 - DNA topoisomerase, type IIA, subunit B, C-terminal IPR013758 - DNA topoisomerase, type IIA, subunit A/ C-terminal, alpha-beta IPR013757 - Type IIA DNA topoisomerase subunit A, alpha-helical domain superfamily IPR006171 - TOPRIM domain IPR003594 - Histidine kinase/HSP90-like ATPase IPR002205 - DNA topoisomerase, type IIA, subunit A/C-terminal IPR001241 - DNA topoisomerase, type IIA IPR001154 - DNA topoisomerase II, eukaryotic-type

Homology

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GenBank top hits

e value

%identity

Alignment

KAG7018075.1 DNA topoisomerase 2 [Cucurbita argyrosperma subsp. argyrosperma]

0.0e+00

84.74

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Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E N ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR ML+G++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK QGKA V +D   ++DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKT--TPEATKEREPGGKLGQKLITQMLEPAEKSN
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KT  T + TK++EP  +LGQKLITQMLEP E S 
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKT--TPEATKEREPGGKLGQKLITQMLEPAEKSN

Query:  ISPEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFE
        ISPEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    E
Subjt:  ISPEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFE

Query:  D
        D
Subjt:  D

XP_022935015.1 DNA topoisomerase 2 isoform X1 [Cucurbita moschata]

0.0e+00

84.79

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Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E N ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR ML+G++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK QGK  V +D   ++DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

XP_022935016.1 DNA topoisomerase 2 isoform X2 [Cucurbita moschata]

0.0e+00

84.72

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Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E N ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR ML+G++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK  GK  V +D   ++DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

XP_022982562.1 DNA topoisomerase 2 isoform X1 [Cucurbita maxima]

0.0e+00

84.86

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+E KRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E NCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR MLDG++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSI+VHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK QGKA V +D G   DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

XP_023527820.1 DNA topoisomerase 2 isoform X1 [Cucurbita pepo subsp. pepo]

0.0e+00

84.71

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+AANV   P G KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E N ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR ML+G++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK QGKA V +D   ++DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSD+ DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLEE---GGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G EE     GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLEE---GGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DGT3 DNA topoisomerase 2

0.0e+00

83.94

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+ ANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        SVKVVIDVE NCISVFNNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDDT KKTTGGRNGYGAKLTNIFSTEFVIETADGKR KKYKQVF DNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        P+ITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLD+AGCLGKTVKVELNGQRV V+SFQDYVDLYLKS S F  EPPKRYH+KPNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVN IAT+KGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGSGCELTPEFLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        A+KSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGG+NSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN VK LRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKE+LR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK F+WQD HDGEAIELAFSKKKIE+RKNW+R +EPGT+LDQTEK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPS+VDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFP+DDD+LLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+Y+PNYNP+DII NV+ +LDG++M+PMDPWY+GFSG IEKT TKEG  +YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK+ L+SVTRVA+K  NDKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FD+NGV+KKYDTPEQILEEFF LRLE+YEKRK NLLE+LE ELL+LENKVRFILAVVNGEI+V NRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIPE----------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPKI
        TDE E+ PE          YLL +AIGTL I+KVQELCN+RD+LK EVEDLR+ATPKSLWLKDLD+LEKELDE DRNDAQAEEVR+QQRIK N + KPKI
Subjt:  TDETEDIPE----------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPKI

Query:  SRN-APKAPRNSKKIADSETVTESID----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLET
        SRN APKAPRNSKK  +SET+ ES+D    STT EVASNA+VKPKGKAAPRKA AKK  GK V  ND   ++DDEVLELKDRLAAYKIDSSPD+ E +ET
Subjt:  SRN-APKAPRNSKKIADSETVTESID----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLET

Query:  KV-----SAKKKEPSKRAAAKKKTTAKSAQTS---DSDDKDFEINEIAPPAAKKGRGGRKATANGKTT--PEATKERE-PGGKLGQKLITQMLEPAEKSN
        +V     +AKKKEPSKRA AKKKTTAKSAQ S   DSDD DFEI E+APPAAKKG GGRKA AN KTT  P A K+RE   GKLGQKLITQML P + + 
Subjt:  KV-----SAKKKEPSKRAAAKKKTTAKSAQTS---DSDDKDFEINEIAPPAAKKGRGGRKATANGKTT--PEATKERE-PGGKLGQKLITQMLEPAEKSN

Query:  ISPEKKVRKIRASPFNKKSGSTLGRVGLE-----EGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        ISPEKKVRK+RASPFNKKSGS LGRVG E     E  GNEGK++ S+ +   EE+  FLPARGRSQRAN TQV+YV+SDSDS+PV E    D++D DF+D
Subjt:  ISPEKKVRKIRASPFNKKSGSTLGRVGLE-----EGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

Query:  E
        E
Subjt:  E

A0A6J1F3D6 DNA topoisomerase 2

0.0e+00

84.72

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E N ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR ML+G++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK  GK  V +D   ++DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

A0A6J1F9E0 DNA topoisomerase 2

0.0e+00

84.79

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+EKKRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E N ISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR ML+G++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSIDVHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK QGK  V +D   ++DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

A0A6J1IWX9 DNA topoisomerase 2

0.0e+00

84.86

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+E KRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E NCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR MLDG++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSI+VHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK QGKA V +D G   DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

A0A6J1J555 DNA topoisomerase 2

0.0e+00

84.79

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Query:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD
        MA+E KRPLQNS+AANV   PAG KKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLW+YENDKMVHRSVTYVPGLYKIFDE+LVNAADNKQRDPSMD
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMD

Query:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE
        S+KVVID E NCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADG+RLKKYKQVFSDNMGKKSE
Subjt:  SVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSE

Query:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV
        PIITKCK G+NWTKVTFKPDL KFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRV V+SFQDYVD YLKS + F  EPPKRYH++PNERWEIVV
Subjt:  PIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVV

Query:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV
        +LSEGQFQQVSFVNGIAT+KGGTHVDYITNQIANYVM VVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQS+FGS CELTP+FLKNV
Subjt:  SLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNV

Query:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT
        ATKSGI+D+VLSWVNFKQSKDLKKTDG KT KISGI KLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPL+GK LNVRE S+KQIT
Subjt:  ATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQIT

Query:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR
         NKEIQ IKQILGLQQGKEYN  KALRYGHLMIMTDQDHDGSHIKGLLINFIH FWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYE+WK+NLR
Subjt:  NNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLR

Query:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS
        GNASGWSIKYYKGLGTSTSKEG+EYFEQL KHKK FIWQD HDGEAIELAFSKKKIE+RKNW+RQ+E GT+LDQ+EK+IKYSDFVNKELIL+S+A+ +RS
Subjt:  GNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRS

Query:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT
        IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQF GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLLLPNGQFGTRNHGGKDHASSRYIYTKLSN T
Subjt:  IPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVT

Query:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS
        RFLFPKDDDKLLNYLNED QSIEPTWYMPIIP VLVNGSEGIGTGWS+YIPNYNP+DIIRNVR MLDG++MLPMDPWYRGFSGTIEKT TKEG T+YTVS
Subjt:  RFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVS

Query:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL
        GIIE V++T LRITELPVR+WTN YK  L+SVTRV++KND DKEKA KDPFIEQ DHHSDDK VSI+VHLTEENM+LA+QEGLK+KFKLTTT+S SNMHL
Subjt:  GIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHL

Query:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
        FDANGV+KKYDTPEQILEEFF LRLEF+EKRKRNLLE+LE ELLKLENKVRFILAVVNGEIIV NRRRVDLFHELQ KGFTPFPKKTKSVEPEVAGASNE
Subjt:  FDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE

Query:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK
        TDE E+ P           EYLL +AIGTL I+KVQELCNERDK K EVE+LR+ATPKSLWLKDLD LEKELDE DRNDAQA+EVR+QQRIK N + KPK
Subjt:  TDETEDIP-----------EYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPK

Query:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--
        ISRNAPKAPRNSKK ++SET+TES+D     STT EVA+N +VKPKGKAAPRKA AKK  GKA V +D G   DDEVLELKDRLAAYK++SSP+  EV  
Subjt:  ISRNAPKAPRNSKKIADSETVTESID-----STTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEV--

Query:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
        +ET+V     +AKKKEPSKRAAAKKKTTAKSAQ S DSDD DFEI EIAPPAAKKG GGRKA AN KTT + TK++EP  +LGQKLITQMLEP E S IS
Subjt:  LETKV-----SAKKKEPSKRAAAKKKTTAKSAQTS-DSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
        PEKKVRKIR SPFNKKSGS LGR +G E    E  GNEGKM+ S+ +  T+E    +P ARGRSQR N TQVRYVVSDSDSEPV EDSD+DEE    ED
Subjt:  PEKKVRKIRASPFNKKSGSTLGR-VGLE----EGGGNEGKMLDSSLTVMTEETTRFLP-ARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

SwissProt top hits

e value

%identity

Alignment

O24308 DNA topoisomerase 2

0.0e+00

60.07

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Query:  KKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKV
        +KRPLQ S+AAN+        KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYEND+MVHR+V+YVPGLYKIFDE+LVNAADNKQRDPSMDS+KV
Subjt:  KKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKV

Query:  VIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIT
         ID E N +SV+NNGDGVPVE+HQEEKVYVPELIFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADG+RLKKYKQVFS+NMG K EP+IT
Subjt:  VIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIT

Query:  KCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSE
        KCK  ENWTKVTFKPDL KF M +LE+DVVALMKKRVLD+AGC GKTVKVELNG  +  +SF+DY DL+LK        P  R H K  +RWEI +SLS+
Subjt:  KCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSE

Query:  GQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVATKS
        GQFQQVSFVN IAT+KGGTHVDYITNQI  Y+MN VNKK K+ANVKAH VK++LWVF+N+LIDNPAFDSQTKETLT RQ++FGS C++    LK+V  KS
Subjt:  GQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVATKS

Query:  GIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKE
        GI+D +LSW +FKQSKDLKKTDGTKT ++ G  K EDAN AGG+NSEKCTLILTEGDSAKALAMAGL VVGRD YGVFPL+GK LNVRE S+KQI +N+E
Subjt:  GIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKE

Query:  IQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNAS
        IQ IK+ILGLQQ KEY  VK+LRYGHLMIM DQDHDGSHIKGLLINFIH FWPSLL+VPSFLVEF TP+++A+H N T+ SFY+MPEYE+WKE L  +A+
Subjt:  IQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNAS

Query:  GWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRSIPSM
         W IKYYKGLGTST +EG+EYF  L +H+K FIW D  DG AIELAFSKKK E RK W+R +EPGT  D   K+I Y DFVNKELIL+S A+        
Subjt:  GWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRSIPSM

Query:  VDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF
                   LF SFK+   KE KV+QF+GYVSEHSAYHHGE+SLA TI+GMAQDFVGSNN+NLL PNGQFGT N GGKDHAS+RYIYT+LS VTR LF
Subjt:  VDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLF

Query:  PKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVSGIIE
         + DDKLL YLNED +SIEP WYMPIIP+VLVNGSEGIGTGWS+YIPNYNP++II NVR +L+G+ ++PMDPWY+GF GTIEK + KEG   Y V+G + 
Subjt:  PKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVSGIIE

Query:  VVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHLFDAN
         ++E   RITELP+R+WT  YK+ L S+T        D     KDP IE    + DD IV I++ +  E +   +QEGL +KFKLT+TIS SNMHLFDA 
Subjt:  VVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHLFDAN

Query:  GVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNETDET
        G  KK+DTPEQILEEFF LRL++YEK K  +L +L   LL L+NKVRFIL VVNGEIIV NR++ +L  EL+ KGFTP P+K KS +P+VAGA+++  E 
Subjt:  GVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNETDET

Query:  EDIPE-------------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKE
        ++  E                    LL + IGTL ++ VQ+L +E+ + ++E E L      SLWLKDLD  EK+LDE D   A+ +  R  Q  K+   
Subjt:  EDIPE-------------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKE

Query:  EKPKISRNAPKAPRNSKKIADSETVTES----IDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLE
           K ++  P+  +N+KK    E   ++    I++         + KPKG+AAP+K + K+P              +D++  L++RLAAY I+SS ++ +
Subjt:  EKPKISRNAPKAPRNSKKIADSETVTES----IDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLE

Query:  VLET----KVSAKKKEPSKRAAAKKKTTA------KSAQTSDSDDKDFEINEIAPPAAKKGRGGRK-ATANGK--------TTPEATKEREPGGK--LGQ
         +E+    + +A KK+ +KR  AKKK++          + +D DD D +  E+   AA   +GGRK A  N K          P A K+R  G K   GQ
Subjt:  VLET----KVSAKKKEPSKRAAAKKKTTA------KSAQTSDSDDKDFEINEIAPPAAKKGRGGRK-ATANGK--------TTPEATKEREPGGK--LGQ

Query:  KLITQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVGLEE-----GGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVA
        KL+T ML+PAE +  SPEKKVRK+R SPFNKKSGS LGR    +        + G   ++ L+          PAR R QRAN TQ++Y +S+S+SE   
Subjt:  KLITQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVGLEE-----GGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVA

Query:  EDSDYDEEDGDFEDE
        EDSD D E  DFE++
Subjt:  EDSDYDEEDGDFEDE

O42130 DNA topoisomerase 2-alpha

0.0e+00

47.39

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Query:  RPLQNSSAANVYPVPAGAKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVH-RSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVK
        RPL ++      P   GA+K  ++E +YQKKTQLEHILLRPDTY+GS+E  TQ +WV++ D  ++ R VT+VPGLYKIFDE+LVNAADNKQRD SM  +K
Subjt:  RPLQNSSAANVYPVPAGAKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVH-RSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVK

Query:  VVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPII
        V ID E+N ISV+NNG G+PV  H+ EKVYVP LIFG LLTSSNYDD EKK TGGRNGYGAKL NIFST+F +ETA  +  K +KQ ++DNMGK  E + 
Subjt:  VVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPII

Query:  TKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLS
         K   GE++T VTF+PDL+KF MT L+ D+VALM +R  D+AG   K VKV LNG+R+ V+ F+ YVDLYLK          K  H + N RWE+ ++LS
Subjt:  TKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLS

Query:  EGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKN-ANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVAT
        E  FQQVSFVN IAT KGG HVDY+ +QI   +++VV KKNKN   VK   VK+++W+F+N+LI+NP FDSQTKE +T++  +FGS C+L+ +F+K  A 
Subjt:  EGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKN-ANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVAT

Query:  KSGIIDNVLSWVNFKQSKDL-KKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITN
          GI++++L+WV FK    L KK    K  KI G+ KL+DAN AG KNS  CTLILTEGDSAK LA++GLGVVGRD YGVFPL+GK LNVRE S+KQI  
Subjt:  KSGIIDNVLSWVNFKQSKDL-KKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITN

Query:  NKEIQCIKQILGLQQGKEY---NTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKEN
        N EI  I +I+GLQ  K Y    ++K+LRYG +MIMTDQD DGSHIKGLLINFIH+ WPSLLR  +FL EFITPI+K + +N   + FY++PE+E WK +
Subjt:  NKEIQCIKQILGLQQGKEY---NTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKEN

Query:  LRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYE-----------PGTYL-DQTEKMIKYSDFVN
         + N + W IKYYKGLGTSTSKE KEYF  + +H+  F +    D  AI LAFSKKK+E+RK W+  +            P  YL  +    + Y+DF+N
Subjt:  LRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYE-----------PGTYL-DQTEKMIKYSDFVN

Query:  KELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDH
        KEL+L+S ++  RSIPS+VDGLKPGQRK+LF  FKRN  +E K +Q  G V+E S+YHHGE SL  TI+ +AQ+FVGSNNLNLL P GQFGTR HGGKD 
Subjt:  KELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDH

Query:  ASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIE
        AS RYI+T LS + R LFP  DD +L +L +D+Q +EP WYMPIIPMVL+NG+EGIGTGWS  IPN++ ++ + N+R +LDGK  LPM P Y+ F GTI+
Subjt:  ASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIE

Query:  KTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEK
        +     G   Y +SG + +++ T + ITELPVR WT  YK++      V     N  EK    P I     +  D  V   V ++EE +  A   GL + 
Subjt:  KTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEK

Query:  FKLTTTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFP--
        FKL T ++ ++M LFD  G LKKY++P+ IL+EFF LRL +Y  RK  L+  L  E  KL N+ RFIL  ++G+I++ N+ + +L   L  +G+   P  
Subjt:  FKLTTTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFP--

Query:  --KKTKSVEPEVAGASNETDETEDIPE--YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELD---ERDRNDAQAEEVRRQ
          K+ ++ E E    S E       P+  YLL M +  L  +K  ELC +RD   +E+EDL+  +P  LW +DL +  +ELD    +   D  A    + 
Subjt:  --KKTKSVEPEVAGASNETDETEDIPE--YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELD---ERDRNDAQAEEVRRQ

Query:  QRIKENKE-EKPKISRNAPKAPRNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSS
         ++K  K+  K K+++          ++  S      +   TAE+ + A  + K K    K  + + Q      N  G++E      LK RLA       
Subjt:  QRIKENKE-EKPKISRNAPKAPRNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSS

Query:  PDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS
          Q    E     +   P K    K K    S   SDS+  DFE+       +K+ R  R+A A  K    +  + +           +  E    S+ +
Subjt:  PDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNIS

Query:  PEKKVRKIRASPFNKK
         +KK  K +A P  KK
Subjt:  PEKKVRKIRASPFNKK

O46374 DNA topoisomerase 2-alpha

0.0e+00

44.67

Show/hide

Query:  MAMEKKRPLQNSSAANVYPVPAGAKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMV-HRSVTYVPGLYKIFDEVLVNAADNKQRDP
        M +   +P+  +   N       AKK  +IE +YQKKTQLEHILLRPDTY+GS+E  TQ +WVY+ D  + +R VT+VPGLYKIFDE+LVNAADNKQRDP
Subjt:  MAMEKKRPLQNSSAANVYPVPAGAKK--TIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMV-HRSVTYVPGLYKIFDEVLVNAADNKQRDP

Query:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK
         M  ++V ID E+N IS++NNG G+PV  H+ EK+YVP LIFG LLTSSNYDD EKK TGGRNGYGAKL NIFST+F +ETA  +  K +KQ + DNMG+
Subjt:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK

Query:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWE
          E +  K   GE++T +TF PDL+KF M  L+ D+VALM +R  D+AG   K VKV LNG ++ V+ F+ YVDLYLK        P K  H + N RWE
Subjt:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWE

Query:  IVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNK-NANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF
        + +++SE  FQQ+SFVN IAT KGG HVDY+ +QI   +++VV KKNK    VKAH VK+++W+F+NALI+NP FDSQTKE +T++  +FGS C+L+ +F
Subjt:  IVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNK-NANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF

Query:  LKNVATKSGIIDNVLSWVNFKQSKDL-KKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVS
        +K  A   GI++++L+WV FK    L KK    K  +I GI KL+DAN AGG+NS +CTLILTEGDSAK LA++GLGVVGRD YGVFPL+GK LNVRE S
Subjt:  LKNVATKSGIIDNVLSWVNFKQSKDL-KKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVS

Query:  NKQITNNKEIQCIKQILGLQQGKEY---NTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEY
        +KQI  N EI  I +I+GLQ  K Y   +++K LRYG +MIMTDQD DGSHIKGLLINFIH+ WPSLLR   FL EFITPIVK + +N   ++FY++PE+
Subjt:  NKQITNNKEIQCIKQILGLQQGKEY---NTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEY

Query:  ESWKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYE-----------PGTYL-DQTEKMIK
        E WK +   N   W +KYYKGLGTSTSKE KEYF  +++H+  F +    D  AI LAFSKK+I+ RK W+  +            P  YL  QT   + 
Subjt:  ESWKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYE-----------PGTYL-DQTEKMIK

Query:  YSDFVNKELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRN
        Y+DF+NKELIL+S ++  RSIPSMVDGLKPGQRK+LF  FKRN  +E KV+Q  G V+E S+YHHGE SL  TI+ +AQ+FVGSNNLNLL P GQFGTR 
Subjt:  YSDFVNKELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRN

Query:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRG
        HGGKD AS RYI+T LS + R LFP  DD  L +L +D+Q +EP WY+PIIPMVL+NG+EGIGTGWS  IPN++ ++++ N+RL++DG+  LPM P Y+ 
Subjt:  HGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRG

Query:  FSGTIEKTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQ
        F GTIE+    +    Y +SG + ++N T + I+ELP+R WT  YK++      V     N  EK    P I     +  D  V   V +TEE +  A +
Subjt:  FSGTIEKTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQ

Query:  EGLKEKFKLTTTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGF
         GL + FKL T+++ ++M LFD  G LKKYDT   IL +FF LRL++Y  RK  LL  L  E  KL N+ RFIL  ++G+II+ N+ + +L   L  +G+
Subjt:  EGLKEKFKLTTTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGF

Query:  TPFPKKT---------KSVEPEVAGASNETDETEDIPE------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERD
           P K             E E +    E D+++ + +      YLL M +  L  +K  ELC  R++ ++E+E L+  +P  LW +DL +  +EL+  +
Subjt:  TPFPKKT---------KSVEPEVAGASNETDETEDIPE------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERD

Query:  RNDAQAEEVRRQQRIKENKEEKPKISRNAP-----------------KAPRNSKKIADSETVTES-------IDSTTAEVASNALVKPKGKAAPRKALAK
          + Q E++    +  + K +K +++   P                 +A +  KK   SE    S       ++     +      +P  K   +  L  
Subjt:  RNDAQAEEVRRQQRIKENKEEKPKISRNAP-----------------KAPRNSKKIADSETVTES-------IDSTTAEVASNALVKPKGKAAPRKALAK

Query:  KPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTA---KSAQTSDSD----DKDFEINEIAPPAAKKG-R
        KP  KA   N + + E D             I S           V  ++KEP +RAAAK K T         SD+D    D+DF  ++ +P  A+   +
Subjt:  KPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTA---KSAQTSDSD----DKDFEINEIAPPAAKKG-R

Query:  GGRKATANGKTTPEAT-------KEREPGGKLGQ----KLITQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVGLEEGGGNEGKMLDSSLTVMTE
           K     K+TP  +       K+  P            +T+ ++P  K N++ +K            KS S+    G ++    +G   D  L     
Subjt:  GGRKATANGKTTPEAT-------KEREPGGKLGQ----KLITQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVGLEEGGGNEGKMLDSSLTVMTE

Query:  ETTRFLPARGRSQRANITQVRYVVSDSDS
        +       +GR +R   T       DSDS
Subjt:  ETTRFLPARGRSQRANITQVRYVVSDSDS

P08096 DNA topoisomerase 2

0.0e+00

47.16

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Query:  IEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVY--ENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEHNCISVFNNGDGVPVE
        +   YQ+ T  EH+L RPDTY+GSIE  T  +WV+  E +K+ +++VTYVPGLYKIFDE++VNAADNK RDP+M+++KV +D E N IS++NNG G+P+E
Subjt:  IEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVY--ENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEHNCISVFNNGDGVPVE

Query:  VHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIITKCKVGENWTKVTFKPDLTKFN
        +H +EK+Y+PELIFG+LLTSSNYDD +KK TGGRNGYGAKL NIFSTEFV+ETAD +R+KKYKQ + DNM +KSEP+IT  K  + +TK+TFKPDL KF 
Subjt:  VHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIITKCKVGENWTKVTFKPDLTKFN

Query:  MTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQQVSFVNGIATVKGGTHV
        M  ++DD+V+++K+R+ D+AG + +T KV LN +R+++  F+ YV++YL S +    EPP+  +   N+RW++  ++S+GQF+QVSFVN I+T++GGTHV
Subjt:  MTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQQVSFVNGIATVKGGTHV

Query:  DYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVATKSGIIDNVLSWVNFKQSKDLKKT
        +Y+ N+I + +  VV K+NK A VKA  +K+Y+ VF+N  I+NP+FDSQTKETLT + S FGS C L+ +FLK +  KS +++ VL +   K  + L K 
Subjt:  DYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVATKSGIIDNVLSWVNFKQSKDLKKT

Query:  DGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKEIQCIKQILGLQQGKEYNTVKA
        DG    +I+G+ KLEDAN AG K S KC LILTEGDSAK+LA++GL VVGRD+YGVFPL+GK LNVRE S+ QI NNKEIQ IK+I+G    K Y  VK 
Subjt:  DGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKEIQCIKQILGLQQGKEYNTVKA

Query:  LRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNASGWSIKYYKGLGTSTSKEGKEY
        LRYGHLMIMTDQDHDGSHIKGL+IN++   +PSLL++P FL++FITPI+K T R   V +FYT+PEYE WKE    N  GW IKYYKGLGTS   + K Y
Subjt:  LRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNASGWSIKYYKGLGTSTSKEGKEY

Query:  FEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFI
        F  L +H K+F      D E IE+AF+KKK + RK W+R Y PG Y+D T+  I   DF+N+ELI +S+A+  RSIPS+VDGLKPGQRK+++  FKRN +
Subjt:  FEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFI

Query:  KEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPT
         E KVS+  GYV+  +AYHHGE S+ +TIV +AQ+FVGSNN+NLL+PNGQFGTR+ GGK+ ++SRY+ T LS + R LF  +DD+LLNY N++ Q IEP 
Subjt:  KEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPT

Query:  WYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKY
        +Y+PI+PMVLVNG+EGIGTGWST+IPNYNPKDI  N+R ML+G+ +  M PWYRGF G+I    TK     Y +SGII  + E  + ITELP+R WT   
Subjt:  WYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKY

Query:  KKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRL
        K+ L +            EK  K  FI   + H  +  V  +V LTE  M  A+ E L+ KFKL+ T + SNM  FDA+G +KKYD+ E IL EF+ +RL
Subjt:  KKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRL

Query:  EFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPF--PKKTKSVEPEVAGASNETDETEDIPE--------YLLGMA
          Y++RK +++ +LE    +  N+ RFI  ++ GE++V  +++ DL  EL+ K F P   PKK   V+ EV  A  E +++ D+ +        YLL M 
Subjt:  EFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPF--PKKTKSVEPEVAGASNETDETEDIPE--------YLLGMA

Query:  IGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPKISRNAPKAPRNSKKIADSETVTESID
        + +L  ++  EL  ++D++  E++ L + TPK LWL DLD+ E   + +  +D Q E +  +Q  ++      K  R      R  + IA S + T ++ 
Subjt:  IGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPKISRNAPKAPRNSKKIADSETVTESID

Query:  STTAEVASNALVKPKGKAAPRKALAKKPQGKAVV------ANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLETKVSAKKKEPSKRAAAK----KKTT
           +  +  +    K +     A +K+P+  + +       N +G   ++  +     L +     S  + + ++++ +  KK   K AA+     +KT 
Subjt:  STTAEVASNALVKPKGKAAPRKALAKKPQGKAVV------ANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLETKVSAKKKEPSKRAAAK----KKTT

Query:  AKSAQT-SDSDDKD------FEINEIAPPAAKKGRGGRKATANGKTTPEATKER--EPGGKLGQKLITQMLEPAEKSNISPEKKVRKIRAS
           A T   SDD+D       + + I    A     G+KA++  K +PE   +    PG     K  +   EP E S+ SP +K    RA+
Subjt:  AKSAQT-SDSDDKD------FEINEIAPPAAKKGRGGRKATANGKTTPEATKER--EPGGKLGQKLITQMLEPAEKSNISPEKKVRKIRAS

P30182 DNA topoisomerase 2

0.0e+00

60.88

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Query:  MEKKRPLQNSSAANVYPVPAGAK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDP
        M  K PLQNS+AANV   PA ++     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDE+LVNAADNKQRD 
Subjt:  MEKKRPLQNSSAANVYPVPAGAK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDP

Query:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK
         MDSV+VVIDVE N ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGK
Subjt:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK

Query:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPP-KRYHVKPNERW
        KSEP+ITKC   ENWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++ V+SF DYVDLYL + +    E P  R   K N+RW
Subjt:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPP-KRYHVKPNERW

Query:  EIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF
        E+ VSLSEGQFQQVSFVN IAT+KGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNPAFDSQTKETLT+RQS+FGS CEL+ +F
Subjt:  EIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF

Query:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSN
        LK V  KSG+++N+LSW +FKQ+KDLKK+DG KTG++  + KL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPL+GK LNVRE S 
Subjt:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSN

Query:  KQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYES
         QITNNKEI+ +K+ILGL+Q  +Y  V +LRYG +MIMTDQDHDGSHIKGLLINFIH FWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE 
Subjt:  KQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYES

Query:  WKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSI
        WKE+L+GNA+GW IKYYKGLGTST++EGKEYF  L  HKK F+W+D  DGEAIELAFSKKKIE RKNW+  Y PG +LDQ +  + YSDFVNKELIL+S+
Subjt:  WKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSI

Query:  ANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYT
        A+ +RSIPSMVDGLKPGQRKILF +FK+   KE KV+Q VGYVS  SAYHHGE+SLA  I+GMAQD+VGSNN+NLLLPNGQFGTR  GGKD AS+RYI+T
Subjt:  ANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYT

Query:  KLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGD
        KLS VTR LFPKDDD LL+YLNED Q IEPTWYMPIIP VLVNG+EGIGTGWST+IPNYNP++I+ NVR +L+G+SM+PMDPWYRGF GTIEKT +KEG 
Subjt:  KLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGD

Query:  TNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTIS
          YT++G+ E V+ET +RITELP+R+W + YK  L S+     K DN        PF + V  ++D+K V  D+ L+EENM+ A QEG  +KFKLTTTI+
Subjt:  TNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTIS

Query:  MSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEV
         SNMHLFD  GV+KKY TPEQILEEFF LR E+YEKRK  +++++E+ELLKLENK RFILAV++GEIIV  R++ D+  +L+ KGFTPFP+K +SVE  +
Subjt:  MSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEV

Query:  AGASNE--TDETEDI---PE------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEV--R
        AGA ++   +E E+I   PE            YLL MAI +L I+KV+EL  +RDK+   V D+++ TPKSLWL DL+SL+KEL++ D  DAQ ++    
Subjt:  AGASNE--TDETEDI---PE------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEV--R

Query:  RQQRIKENKEEKPKISRNAPKAP---RNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLEL---KDRLA
         Q++I+       K+ R APK P   + +KK ++SET   S  +   +     +VKPK +   +K   K  + +   A+    + D+ V E+   K R  
Subjt:  RQQRIKENKEEKPKISRNAPKAP---RNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLEL---KDRLA

Query:  AYK----IDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLI--
        A K         ++ E+L+      +       A   KT   S   +  DD D  + E+AP      +GGRK  A     P A        K G++ +  
Subjt:  AYK----IDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLI--

Query:  TQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVG-LEEGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDE
        T++L       +SPEKKVRK+R+SPFNKKS S + R+   +E   +E    +SS    +E++   + A  R QRAN  ++ YV+SDS+SE  A DS++D+
Subjt:  TQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVG-LEEGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDE

Query:  EDGDFEDE
         + D +DE
Subjt:  EDGDFEDE

Arabidopsis top hits

e value

%identity

Alignment

AT2G13720.1 DNA topoisomerase (ATP-hydrolyzing)s;ATP binding;DNA binding

2.8e-14

34.97

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Query:  WPSLLRVP------SFLVEFITPIVK------ATHRNGTV---LSFYTMP-EYESWKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQ
        WP  +RVP      SF+   +TP VK      ++H+   V   LS+ T      + K   R   + W+IK+YKG+     +E K     + ++K+ FIW 
Subjt:  WPSLLRVP------SFLVEFITPIVK------ATHRNGTV---LSFYTMP-EYESWKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQ

Query:  DAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILY-SIANARRSI
        +  +  A+E AF   + +Q+K WI +Y PGT+LD  ++ I YSDFV K+L LY + +N R+ I
Subjt:  DAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILY-SIANARRSI

AT3G10270.1 DNA GYRASE B1

1.6e-22

24.34

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Query:  GLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFSTEF
        GL+ +  E+L NA D  Q       + VV+  + + +S+ +NG G+P ++H        E +   L     +         +GG +G G  + N  S   
Subjt:  GLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFSTEF

Query:  -VIETADGKRLKKYKQVFSDNMGKKSEPIIT-KCKV------GENWTKVTFKPDLTKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRS
         VI   DG    +++Q +S     + +P+ T  C V      G   T + F PD   F      + + +A   + +  L   +  ++K E +     V S
Subjt:  -VIETADGKRLKKYKQVFSDNMGKKSEPIIT-KCKV------GENWTKVTFKPDLTKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRS

Query:  FQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQ---------QVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKS
           Y     +  S +L    K  H     R EI  S  +   Q          + + N I T+ GGTH++ +   +    +N + KK K   VK + + S
Subjt:  FQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQ---------QVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKS

Query:  YLWV-------------------------------------FINALIDNPAFDSQTKETL---TIR-------QSNFGSGCELTPEFLKNVATKSGIIDN
          W+                                      ++  + NP F+ QTK  L    +R       Q       EL P+ L+++ +KS  ++ 
Subjt:  YLWV-------------------------------------FINALIDNPAFDSQTKETL---TIR-------QSNFGSGCELTPEFLKNVATKSGIIDN

Query:  VLSWVNFKQSKDLKKTDGT-KTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKEIQCI
          + +  K++++L ++    K+  + G  KL D +      SE   + + EGDSA   A  G     R F  + PL+GK LN+       +  N+EIQ +
Subjt:  VLSWVNFKQSKDLKKTDGT-KTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKEIQCI

Query:  KQILGL-QQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNASGWS
           LGL  +G+++N  + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   R       Y     +    +  GNAS ++
Subjt:  KQILGL-QQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNASGWS

Query:  IKYYKGLG
        I+ +KGLG
Subjt:  IKYYKGLG

AT3G23890.1 topoisomerase II

0.0e+00

60.88

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Query:  MEKKRPLQNSSAANVYPVPAGAK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDP
        M  K PLQNS+AANV   PA ++     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDE+LVNAADNKQRD 
Subjt:  MEKKRPLQNSSAANVYPVPAGAK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDP

Query:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK
         MDSV+VVIDVE N ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGK
Subjt:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK

Query:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPP-KRYHVKPNERW
        KSEP+ITKC   ENWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++ V+SF DYVDLYL + +    E P  R   K N+RW
Subjt:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPP-KRYHVKPNERW

Query:  EIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF
        E+ VSLSEGQFQQVSFVN IAT+KGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNPAFDSQTKETLT+RQS+FGS CEL+ +F
Subjt:  EIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF

Query:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSN
        LK V  KSG+++N+LSW +FKQ+KDLKK+DG KTG++  + KL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPL+GK LNVRE S 
Subjt:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSN

Query:  KQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYES
         QITNNKEI+ +K+ILGL+Q  +Y  V +LRYG +MIMTDQDHDGSHIKGLLINFIH FWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE 
Subjt:  KQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYES

Query:  WKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSI
        WKE+L+GNA+GW IKYYKGLGTST++EGKEYF  L  HKK F+W+D  DGEAIELAFSKKKIE RKNW+  Y PG +LDQ +  + YSDFVNKELIL+S+
Subjt:  WKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSI

Query:  ANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYT
        A+ +RSIPSMVDGLKPGQRKILF +FK+   KE KV+Q VGYVS  SAYHHGE+SLA  I+GMAQD+VGSNN+NLLLPNGQFGTR  GGKD AS+RYI+T
Subjt:  ANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYT

Query:  KLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGD
        KLS VTR LFPKDDD LL+YLNED Q IEPTWYMPIIP VLVNG+EGIGTGWST+IPNYNP++I+ NVR +L+G+SM+PMDPWYRGF GTIEKT +KEG 
Subjt:  KLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGD

Query:  TNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTIS
          YT++G+ E V+ET +RITELP+R+W + YK  L S+     K DN        PF + V  ++D+K V  D+ L+EENM+ A QEG  +KFKLTTTI+
Subjt:  TNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTIS

Query:  MSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEV
         SNMHLFD  GV+KKY TPEQILEEFF LR E+YEKRK  +++++E+ELLKLENK RFILAV++GEIIV  R++ D+  +L+ KGFTPFP+K +SVE  +
Subjt:  MSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEV

Query:  AGASNE--TDETEDI---PE------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEV--R
        AGA ++   +E E+I   PE            YLL MAI +L I+KV+EL  +RDK+   V D+++ TPKSLWL DL+SL+KEL++ D  DAQ ++    
Subjt:  AGASNE--TDETEDI---PE------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEV--R

Query:  RQQRIKENKEEKPKISRNAPKAP---RNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLEL---KDRLA
         Q++I+       K+ R APK P   + +KK ++SET   S  +   +     +VKPK +   +K   K  + +   A+    + D+ V E+   K R  
Subjt:  RQQRIKENKEEKPKISRNAPKAP---RNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLEL---KDRLA

Query:  AYK----IDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLI--
        A K         ++ E+L+      +       A   KT   S   +  DD D  + E+AP      +GGRK  A     P A        K G++ +  
Subjt:  AYK----IDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLI--

Query:  TQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVG-LEEGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDE
        T++L       +SPEKKVRK+R+SPFNKKS S + R+   +E   +E    +SS    +E++   + A  R QRAN  ++ YV+SDS+SE  A DS++D+
Subjt:  TQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVG-LEEGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDE

Query:  EDGDFEDE
         + D +DE
Subjt:  EDGDFEDE

AT3G23890.2 topoisomerase II

0.0e+00

61.63

Show/hide

Query:  MEKKRPLQNSSAANVYPVPAGAK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDP
        M  K PLQNS+AANV   PA ++     KTIEEMYQKK+QLEHILLRPDTY+GSIEKHTQ LWVYE D+MV R VTYVPGLYKIFDE+LVNAADNKQRD 
Subjt:  MEKKRPLQNSSAANVYPVPAGAK-----KTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDP

Query:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK
         MDSV+VVIDVE N ISV N+G GVPVE+HQEE +YVPE+IFGHLLTSSNYDD  KKTTGGRNGYGAKLTNIFSTEF+IETADGKRLKKYKQVF +NMGK
Subjt:  SMDSVKVVIDVEHNCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGK

Query:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPP-KRYHVKPNERW
        KSEP+ITKC   ENWTKVTFKPDL KFNMT LEDDVVALM KRV D+AGCLGK+VKVELNG+++ V+SF DYVDLYL + +    E P  R   K N+RW
Subjt:  KSEPIITKCKVGENWTKVTFKPDLTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPP-KRYHVKPNERW

Query:  EIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF
        E+ VSLSEGQFQQVSFVN IAT+KGGTHVDY+T+QI N+++  VNKKNKNANVKAHNVK++LWVF+NALIDNPAFDSQTKETLT+RQS+FGS CEL+ +F
Subjt:  EIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITNQIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEF

Query:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSN
        LK V  KSG+++N+LSW +FKQ+KDLKK+DG KTG++  + KL+DA  AGGKNS  CTLILTEGDSAK+LA+AG  V+G ++ GVFPL+GK LNVRE S 
Subjt:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSN

Query:  KQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYES
         QITNNKEI+ +K+ILGL+Q  +Y  V +LRYG +MIMTDQDHDGSHIKGLLINFIH FWPSLL+VPSFLVEFITPIVKAT R GT  VLSFY+MPEYE 
Subjt:  KQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGT--VLSFYTMPEYES

Query:  WKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSI
        WKE+L+GNA+GW IKYYKGLGTST++EGKEYF  L  HKK F+W+D  DGEAIELAFSKKKIE RKNW+  Y PG +LDQ +  + YSDFVNKELIL+S+
Subjt:  WKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRKNWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSI

Query:  ANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYT
        A+ +RSIPSMVDGLKPGQRKILF +FK+   KE KV+Q VGYVS  SAYHHGE+SLA  I+GMAQD+VGSNN+NLLLPNGQFGTR  GGKD AS+RYI+T
Subjt:  ANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLLLPNGQFGTRNHGGKDHASSRYIYT

Query:  KLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGD
        KLS VTR LFPKDDD LL+YLNED Q IEPTWYMPIIP VLVNG+EGIGTGWST+IPNYNP++I+ NVR +L+G+SM+PMDPWYRGF GTIEKT +KEG 
Subjt:  KLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRGFSGTIEKTTTKEGD

Query:  TNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTIS
          YT++G+ E V+ET +RITELP+R+W + YK  L S+     K DN        PF + V  ++D+K V  D+ L+EENM+ A QEG  +KFKLTTTI+
Subjt:  TNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLTTTIS

Query:  MSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEV
         SNMHLFD  GV+KKY TPEQILEEFF LR E+YEKRK  +++++E+ELLKLENK RFILAV++GEIIV  R++ D+  +L+ KGFTPFP+K +SVE  +
Subjt:  MSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEV

Query:  AGASNE--TDETEDI---PE------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEV--R
        AGA ++   +E E+I   PE            YLL MAI +L I+KV+EL  +RDK+   V D+++ TPKSLWL DL+SL+KEL++ D  DAQ ++    
Subjt:  AGASNE--TDETEDI---PE------------YLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEV--R

Query:  RQQRIKENKEEKPKISRNAPKAP---RNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYK
         Q++I+       K+ R APK P   + +KK ++SET   S  +   +     +VKPKG+   +K        KA  A    E E+DE+L+L  RLA Y 
Subjt:  RQQRIKENKEEKPKISRNAPKAP---RNSKKIADSETVTESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYK

Query:  IDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLI--TQMLEPA
          S+P          S+K  E SK  A               DD D  + E+AP      +GGRK  A     P A        K G++ +  T++L   
Subjt:  IDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFEINEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLI--TQMLEPA

Query:  EKSNISPEKKVRKIRASPFNKKSGSTLGRVG-LEEGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED
            +SPEKKVRK+R+SPFNKKS S + R+   +E   +E    +SS    +E++   + A  R QRAN  ++ YV+SDS+SE  A DS++D+ + D +D
Subjt:  EKSNISPEKKVRKIRASPFNKKSGSTLGRVG-LEEGGGNEGKMLDSSLTVMTEETTRFLPARGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFED

Query:  E
        E
Subjt:  E

AT5G04130.1 DNA GYRASE B2

4.4e-28

24.68

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Query:  EMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEHNCISVFNNGDGVPVEVHQE
        E  Q    L+ +  RP  Y+GS                     T   GL+ +  E+L NA D  Q   +   V VV+  +   +SV +NG G+P ++H  
Subjt:  EMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEHNCISVFNNGDGVPVEVHQE

Query:  EKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIT-KCKV------GENWTKVTFKPD
         K    E +   L     +  T      +GG +G G  + N  S    +E +  +   ++KQ +S     + +PI T  C+V      G   T + F PD
Subjt:  EKVYVPELIFGHLLTSSNYDDTEK--KTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIIT-KCKV------GENWTKVTFKPD

Query:  LTKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQ---------QV
           F      + + +A   + +  L   +  ++K E +    T  S   +     +  S +L       H     R EI  +  +   Q          +
Subjt:  LTKFNMT-HLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQ---------QV

Query:  SFVNGIATVKGGTHVDYITNQIANYVMNVVNK----KNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETL---TIR-------QSNFGSGCELTPEF
         + N I T+ GGTH++ +   +   +  +  K    K K+ ++   +V+  L   ++  + NP F+ QTK  L    +R       Q       EL P+ 
Subjt:  SFVNGIATVKGGTHVDYITNQIANYVMNVVNK----KNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETL---TIR-------QSNFGSGCELTPEF

Query:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGT-KTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVS
        L+++ +KS  ++   + +  K++++L ++    K+  + G  KL D +    + SE   + + EGDSA   A  G     R F  + PL+GK LN+    
Subjt:  LKNVATKSGIIDNVLSWVNFKQSKDLKKTDGT-KTGKISGIAKLEDANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVS

Query:  NKQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESW
           +  N+EIQ +   LGL    E    + LRY  ++I+TD D DG+HI+ LL+ F   +  +L       V  + P+ K   R       Y   + +  
Subjt:  NKQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLINFIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESW

Query:  KENLRGNASGWSIKYYKGLG
          N   NAS ++I+ +KGLG
Subjt:  KENLRGNASGWSIKYYKGLG

Sequences

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CDS sequence

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ATGGCCATGGAGAAGAAGCGACCACTGCAGAACAGCAGCGCCGCCAATGTATACCCGGTTCCGGCAGGGGCGAAGAAAACCATTGAAGAAATGTATCAGAAGAAGACTCA
ACTCGAGCACATCCTGCTTAGGCCCGATACCTACGTCGGATCAATCGAAAAACACACTCAAAATCTCTGGGTTTACGAGAACGACAAGATGGTTCACCGATCTGTCACTT
ATGTACCCGGTCTTTACAAGATCTTTGATGAAGTTTTGGTCAATGCTGCAGATAATAAGCAGAGAGACCCTTCGATGGACTCGGTCAAGGTTGTAATTGATGTTGAACAC
AACTGTATCAGCGTGTTCAACAATGGTGACGGAGTTCCGGTTGAGGTTCATCAGGAAGAGAAGGTATATGTGCCTGAGTTGATCTTTGGACATTTGTTGACTAGTAGTAA
TTATGACGATACTGAGAAGAAAACCACTGGTGGTCGTAATGGCTATGGTGCGAAACTTACAAATATATTTTCGACTGAATTTGTGATTGAGACGGCCGATGGAAAACGCC
TGAAGAAGTATAAACAGGTATTCTCTGATAACATGGGGAAAAAATCTGAGCCAATCATAACAAAGTGCAAAGTGGGTGAAAATTGGACCAAGGTGACTTTTAAGCCAGAC
TTGACAAAGTTTAACATGACTCATCTTGAAGATGATGTTGTTGCCCTCATGAAAAAGAGGGTGTTAGATCTGGCGGGATGTCTCGGAAAAACCGTGAAGGTTGAGTTGAA
CGGACAAAGGGTCACTGTCAGATCGTTTCAAGATTATGTGGATCTCTACCTCAAATCGACCTCGCCATTCCTGCTAGAACCTCCAAAAAGGTACCATGTCAAGCCAAATG
AGAGATGGGAAATCGTGGTGAGCTTAAGTGAGGGGCAATTCCAGCAGGTAAGCTTTGTAAACGGAATTGCAACCGTAAAGGGTGGAACTCATGTTGATTACATCACTAAT
CAGATAGCAAATTATGTGATGAATGTTGTAAATAAGAAAAACAAGAATGCTAACGTGAAGGCCCACAACGTGAAGAGTTACTTGTGGGTTTTTATCAACGCTCTTATTGA
TAATCCTGCCTTTGACTCCCAAACCAAGGAAACTTTGACAATTCGCCAAAGCAATTTCGGTTCTGGCTGTGAACTTACACCAGAGTTTTTGAAGAATGTGGCCACGAAAT
CTGGAATTATAGACAATGTTCTCTCGTGGGTTAATTTCAAACAAAGCAAAGATTTGAAAAAAACAGATGGAACAAAAACAGGAAAGATTAGTGGTATTGCAAAGTTGGAG
GATGCAAATTGCGCTGGAGGGAAAAATTCAGAAAAATGTACCTTGATTTTGACAGAAGGAGATTCAGCTAAGGCCCTTGCGATGGCCGGGCTTGGTGTAGTGGGACGAGA
CTTCTATGGCGTGTTTCCATTGAAAGGTAAATTTCTCAACGTGAGGGAAGTGAGTAACAAACAGATCACAAACAATAAAGAAATTCAGTGCATCAAGCAAATTCTTGGAC
TTCAGCAAGGGAAGGAATACAACACTGTCAAGGCTTTGAGATATGGCCATTTGATGATTATGACTGATCAGGATCATGATGGTTCACACATTAAAGGACTCTTGATCAAC
TTTATTCACTATTTCTGGCCTTCTCTCCTAAGGGTGCCGTCTTTCTTGGTTGAGTTCATAACGCCTATTGTCAAGGCTACTCATAGAAATGGAACTGTCTTATCATTCTA
TACAATGCCTGAGTACGAGTCTTGGAAAGAGAACTTGAGGGGCAATGCAAGTGGTTGGTCAATCAAGTACTATAAGGGGTTGGGAACAAGCACGTCAAAAGAAGGAAAAG
AGTACTTTGAACAACTGCAAAAGCACAAGAAACATTTTATTTGGCAAGATGCCCATGATGGAGAGGCCATTGAACTTGCGTTCAGTAAGAAGAAGATTGAACAGAGGAAA
AATTGGATCCGTCAATATGAGCCTGGTACCTATCTAGATCAGACAGAAAAAATGATAAAATACAGTGACTTTGTCAACAAAGAGCTTATATTATATTCAATCGCTAATGC
ACGAAGGTCTATTCCCTCAATGGTTGATGGCCTCAAGCCTGGCCAGAGGAAGATCCTTTTCTGTTCTTTCAAGAGGAACTTTATCAAAGAAGCAAAAGTTTCTCAATTTG
TCGGTTATGTATCTGAGCACTCTGCTTATCATCATGGTGAGGAGAGTCTTGCTCGCACCATCGTTGGAATGGCACAAGACTTTGTCGGCAGCAACAACTTAAATCTTCTT
CTGCCAAATGGACAGTTTGGCACTCGGAACCATGGAGGCAAAGATCATGCAAGTTCTAGGTACATTTACACTAAGCTTTCAAATGTTACACGGTTCCTTTTCCCAAAAGA
CGACGACAAACTTCTTAATTACTTAAATGAAGACGACCAGTCGATTGAACCAACTTGGTACATGCCTATCATACCAATGGTTCTTGTCAACGGAAGTGAAGGAATTGGAA
CTGGGTGGAGTACGTACATTCCAAATTATAATCCTAAAGATATCATTAGAAATGTAAGACTCATGTTGGACGGTAAATCAATGTTGCCAATGGATCCTTGGTATAGAGGC
TTTTCAGGAACTATAGAGAAAACTACCACTAAAGAAGGAGACACTAATTACACTGTTAGTGGAATCATCGAGGTAGTCAACGAAACGATGTTGAGAATAACTGAACTGCC
AGTCCGCCAATGGACTAATAAGTATAAGAAAGAACTTAATTCTGTCACGAGAGTTGCATCCAAGAATGACAATGACAAAGAAAAAGCAACAAAGGATCCTTTTATTGAGC
AAGTTGATCATCACAGCGATGACAAAATTGTTTCCATTGATGTGCACTTGACAGAGGAAAACATGATGCTGGCCGTCCAGGAGGGTTTGAAGGAGAAATTCAAGTTAACT
ACTACTATCAGCATGAGCAACATGCATCTGTTTGATGCAAATGGCGTCCTTAAGAAATATGACACCCCAGAACAAATTCTGGAGGAATTTTTCCACCTTAGACTTGAATT
CTATGAGAAAAGAAAGAGGAATCTTTTGGAAGACCTTGAAATGGAGTTGCTCAAACTGGAAAACAAGGTTAGGTTTATCCTTGCTGTTGTGAATGGAGAGATAATAGTGG
GCAATAGAAGAAGAGTTGATTTGTTCCATGAGCTTCAAGCAAAAGGCTTTACTCCCTTTCCAAAGAAGACGAAATCTGTTGAGCCAGAGGTTGCTGGGGCATCTAATGAA
ACAGATGAAACAGAAGACATTCCGGAATATCTACTTGGAATGGCAATTGGAACCTTGATCATCGACAAGGTTCAGGAGCTGTGCAATGAAAGAGACAAGCTCAAAAGGGA
AGTGGAAGATCTGAGGGAGGCAACTCCCAAGTCTTTGTGGCTGAAAGATCTTGATTCTCTTGAGAAGGAACTTGATGAGAGGGATAGAAATGATGCTCAAGCAGAGGAGG
TAAGAAGACAACAGAGAATCAAAGAAAATAAGGAAGAAAAGCCAAAGATCTCTAGAAATGCACCAAAAGCTCCACGTAACAGTAAAAAAATCGCCGATTCAGAAACTGTC
ACAGAGAGTATAGATTCTACAACAGCTGAAGTTGCAAGTAATGCTTTGGTGAAGCCCAAAGGCAAAGCAGCTCCAAGAAAAGCTCTAGCCAAAAAGCCGCAAGGTAAAGC
TGTAGTTGCCAACGATTATGGTGAAGAAGAGGATGACGAAGTGCTAGAGCTTAAAGATCGTCTTGCCGCCTATAAAATTGATTCATCTCCCGATCAATTAGAAGTGCTAG
AAACCAAAGTGTCGGCCAAGAAGAAAGAACCCAGCAAGAGAGCAGCTGCCAAGAAGAAAACTACTGCAAAGTCTGCTCAGACTTCTGACAGTGACGACAAGGACTTTGAA
ATAAATGAGATAGCCCCTCCGGCAGCCAAGAAGGGAAGAGGAGGAAGAAAGGCAACTGCAAATGGCAAAACAACCCCTGAGGCAACAAAGGAGCGAGAGCCGGGGGGGAA
GTTGGGGCAGAAACTGATAACTCAAATGTTGGAGCCGGCGGAGAAATCGAATATCTCGCCGGAGAAGAAAGTGAGGAAAATAAGAGCATCTCCTTTCAACAAGAAAAGTG
GGTCTACCCTGGGAAGAGTTGGGTTAGAAGAAGGAGGTGGAAATGAAGGGAAGATGTTGGATTCTTCTTTGACTGTGATGACTGAAGAAACTACTAGATTTCTGCCGGCG
AGAGGAAGATCACAGAGGGCCAACATAACTCAGGTGAGATATGTGGTTAGTGATTCGGACAGTGAGCCAGTTGCTGAGGATTCGGACTATGACGAAGAAGATGGCGATTT
TGAAGACGAGTGA

mRNA sequence

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Protein sequence

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MAMEKKRPLQNSSAANVYPVPAGAKKTIEEMYQKKTQLEHILLRPDTYVGSIEKHTQNLWVYENDKMVHRSVTYVPGLYKIFDEVLVNAADNKQRDPSMDSVKVVIDVEH
NCISVFNNGDGVPVEVHQEEKVYVPELIFGHLLTSSNYDDTEKKTTGGRNGYGAKLTNIFSTEFVIETADGKRLKKYKQVFSDNMGKKSEPIITKCKVGENWTKVTFKPD
LTKFNMTHLEDDVVALMKKRVLDLAGCLGKTVKVELNGQRVTVRSFQDYVDLYLKSTSPFLLEPPKRYHVKPNERWEIVVSLSEGQFQQVSFVNGIATVKGGTHVDYITN
QIANYVMNVVNKKNKNANVKAHNVKSYLWVFINALIDNPAFDSQTKETLTIRQSNFGSGCELTPEFLKNVATKSGIIDNVLSWVNFKQSKDLKKTDGTKTGKISGIAKLE
DANCAGGKNSEKCTLILTEGDSAKALAMAGLGVVGRDFYGVFPLKGKFLNVREVSNKQITNNKEIQCIKQILGLQQGKEYNTVKALRYGHLMIMTDQDHDGSHIKGLLIN
FIHYFWPSLLRVPSFLVEFITPIVKATHRNGTVLSFYTMPEYESWKENLRGNASGWSIKYYKGLGTSTSKEGKEYFEQLQKHKKHFIWQDAHDGEAIELAFSKKKIEQRK
NWIRQYEPGTYLDQTEKMIKYSDFVNKELILYSIANARRSIPSMVDGLKPGQRKILFCSFKRNFIKEAKVSQFVGYVSEHSAYHHGEESLARTIVGMAQDFVGSNNLNLL
LPNGQFGTRNHGGKDHASSRYIYTKLSNVTRFLFPKDDDKLLNYLNEDDQSIEPTWYMPIIPMVLVNGSEGIGTGWSTYIPNYNPKDIIRNVRLMLDGKSMLPMDPWYRG
FSGTIEKTTTKEGDTNYTVSGIIEVVNETMLRITELPVRQWTNKYKKELNSVTRVASKNDNDKEKATKDPFIEQVDHHSDDKIVSIDVHLTEENMMLAVQEGLKEKFKLT
TTISMSNMHLFDANGVLKKYDTPEQILEEFFHLRLEFYEKRKRNLLEDLEMELLKLENKVRFILAVVNGEIIVGNRRRVDLFHELQAKGFTPFPKKTKSVEPEVAGASNE
TDETEDIPEYLLGMAIGTLIIDKVQELCNERDKLKREVEDLREATPKSLWLKDLDSLEKELDERDRNDAQAEEVRRQQRIKENKEEKPKISRNAPKAPRNSKKIADSETV
TESIDSTTAEVASNALVKPKGKAAPRKALAKKPQGKAVVANDYGEEEDDEVLELKDRLAAYKIDSSPDQLEVLETKVSAKKKEPSKRAAAKKKTTAKSAQTSDSDDKDFE
INEIAPPAAKKGRGGRKATANGKTTPEATKEREPGGKLGQKLITQMLEPAEKSNISPEKKVRKIRASPFNKKSGSTLGRVGLEEGGGNEGKMLDSSLTVMTEETTRFLPA
RGRSQRANITQVRYVVSDSDSEPVAEDSDYDEEDGDFEDE

Tan0005124 (gene) of Snake gourd v1 genome