CuGenDBv2

Gene ID	Tan0005321
Organism	Trichosanthes anguina (Snake gourd v1)
Description	3-hydroxy-3-methylglutaryl coenzyme A synthase
Genome location	LG01:21407156..21412137
RNA-Seq Expression	Tan0005321
Synteny	Tan0005321
Gene Ontology terms	GO:0006084 - acetyl-CoA metabolic process (biological process) GO:0010142 - farnesyl diphosphate biosynthetic process, mevalonate pathway (biological process) GO:0016126 - sterol biosynthetic process (biological process) GO:0004421 - hydroxymethylglutaryl-CoA synthase activity (molecular function)
InterPro domains	IPR000590 - Hydroxymethylglutaryl-coenzyme A synthase, active site IPR010122 - Hydroxymethylglutaryl-CoA synthase, eukaryotic IPR013528 - Hydroxymethylglutaryl-coenzyme A synthase, N-terminal IPR013746 - Hydroxymethylglutaryl-coenzyme A synthase, C-terminal domain IPR016039 - Thiolase-like

Homology

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GenBank top hits

e value

%identity

Alignment

AEM42970.1 hydroxymethylglutaryl-CoA synthase [Siraitia grosvenorii]

2.6e-258

95.91

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Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLS DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKH +LSGNRVILFSYGSGSTATMFSLK+NEGQHPFSLSNIAAILNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKF+EIM+LMEHRYGAKDF TSKDCSLLSPGTYYLTEVDSLYRRFYA  DG+S + ENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

XP_022152764.1 hydroxymethylglutaryl-CoA synthase [Momordica charantia]

7.5e-258

95.27

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Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKN GIL +DIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVES+SWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFS+SDADYFVFHSPYNKLVQKSFARL+FNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISL+HNKH+SLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNI+A+LNVDKKLKSRHEL+P
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIM+LMEHRYGAKDF TSKDCSLL PGTYYLTEVDSLYRRFYA KD ES ++ENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

XP_023540800.1 hydroxymethylglutaryl-CoA synthase-like [Cucurbita pepo subsp. pepo]

2.2e-257

95.27

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Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPT VQQEALEAHDGASKGKYTIGLGQDCMAFC+EVEDVISMSLTVVTSLLEKY IDPKQ+GRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTD+EGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQF+ISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSID+V KEKLAPFSTLSNDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ITQQLAKPLYD+KVQPSTLIPKQVGNMYTASLYAAFISLLHNKH+SLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSN+AA+LNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIM+LMEHRYGAKDF T+KDCSLL PGTYYLTEVDSLYRRFYA KDGE EK++NGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

XP_023553213.1 hydroxymethylglutaryl-CoA synthase-like [Cucurbita pepo subsp. pepo]

1.3e-257

95.7

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Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTY+QQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDF RNASSIDEVAKEKLAPFSTLSNDE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+ SL+GNRV+LFSYGSGSTATMFSLK+NEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIMQLMEHRYGAKDF TSKDCSLL  G+YYLTEVDSLYRRFYA KDGESEK+ENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

XP_038903028.1 hydroxymethylglutaryl-CoA synthase [Benincasa hispida]

4.0e-259

96.99

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Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MA NVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLT VTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFSIS+ADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDE AKEKLAPFS LSNDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+ SL GNRVILFSYGSGSTATMFSLK+NEGQ+PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIMQLMEHRYGAKDF TSKDCSLLSPGTYYLTEVDSLYRRFYA KDGESEKIENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

TrEMBL top hits

e value

%identity

Alignment

A0A6J1DH00 3-hydroxy-3-methylglutaryl coenzyme A synthase

3.6e-258

95.27

Show/hide

Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKN GIL +DIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVES+SWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFS+SDADYFVFHSPYNKLVQKSFARL+FNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISL+HNKH+SLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNI+A+LNVDKKLKSRHEL+P
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIM+LMEHRYGAKDF TSKDCSLL PGTYYLTEVDSLYRRFYA KD ES ++ENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

A0A6J1E6B9 3-hydroxy-3-methylglutaryl coenzyme A synthase

6.8e-257

95.27

Show/hide

Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DI+FPPTY++QEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDF RNASSIDEVAKEKLAPFSTLSNDE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNK+ SL+GNRV+LFSYGSGSTATMFSLK+NEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIMQLMEHRYGAKDF TSKDCSLL  G+YYLTEVDSLYRRFYA KDGESEK+ENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

A0A6J1FE30 3-hydroxy-3-methylglutaryl coenzyme A synthase

3.1e-257

95.48

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Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPT VQQEALEAHDGASKGKYTIGLGQDCMAFC+EVEDVISMSLTVVTSLLEKY IDPKQ+GRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGK+F+ISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEV KEKLAPFSTLSNDESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ITQQLAKPLYD+KVQPSTLIPKQVGNMYTASLYAAFISLLHNKH+SLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSN+AAILNVDKKLKSR ELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIM+LMEHRYGAKDF T+KDCSLL PGTYYLTEVDSLYRRFYA KDGE EK++NGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

A0A6J1HPX8 3-hydroxy-3-methylglutaryl coenzyme A synthase

1.2e-256

95.27

Show/hide

Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTY+QQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAML+GPDAPI FESKLRGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDF RNASSIDEVAKEKLAPFSTLSNDE+YQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHN++ SL+GNRV+LFSYGSGSTATMFSLK+NEGQ PFSLSNI+AILNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVEIMQLMEHRYGAKDF TSKDCSLL  G+YYLTEVDSLYRRFYA KDGESE IEN VVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

K7NBW5 3-hydroxy-3-methylglutaryl coenzyme A synthase

1.2e-258

95.91

Show/hide

Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EKHGNTDIEGVDSTNACYGGTAAL NCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFES++RGSHMSHVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLS DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        I+QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKH +LSGNRVILFSYGSGSTATMFSLK+NEGQHPFSLSNIAAILNVDKKLKSRHELVP
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKF+EIM+LMEHRYGAKDF TSKDCSLLSPGTYYLTEVDSLYRRFYA  DG+S + ENGVVANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

SwissProt top hits

e value

%identity

Alignment

P54868 Hydroxymethylglutaryl-CoA synthase, mitochondrial

1.6e-122

49.67

Show/hide

Query:  KNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK
        K+VGILAL++YFP  YV Q  LE ++    GKYT+GLGQ  M FC+  ED+ S+ LTVV  L+E+  +    +GRLEVG+ET+IDKSK++KT LM++F+ 
Subjt:  KNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK

Query:  HGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYP
         GNTDIEG+D+TNACYGGTA+LFN  NW+ESSSWDGRY +VVC D AVY  G ARPTGGA A+AMLIGP AP+A E  LRG+HM +VYDFYKPNLASEYP
Subjt:  HGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYP

Query:  VVDGKLSQTCYLMALD---SSYKQLCHKYEKLEG--KQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRD
        +VDGKLS  CYL ALD   +SY++      K  G  + F++ D  Y +FH+P+ K+VQKS ARL+FNDF   +S       + L  F  L  +++Y ++D
Subjt:  VVDGKLSQTCYLMALD---SSYKQLCHKYEKLEG--KQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRD

Query:  LEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSN--IAAILNVDKKLKS
        L+K   + ++ ++D K + S  +    GNMYT+SLY    SLL H+    L+G+R+  FSYGSG  A+ FS ++++   P S  +  +++  ++ K+L S
Subjt:  LEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSN--IAAILNVDKKLKS

Query:  RHELVPEKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATK
        R  + PE+F EIM   E  Y   +F+   D + L PGT+YL  VD  +RR YA +
Subjt:  RHELVPEKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATK

P54872 Hydroxymethylglutaryl-CoA synthase A

2.1e-125

49.78

Show/hide

Query:  KNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK
        +N+GI  +++YFP TYV QE LE  DG S+GKYT+GLGQ  MAFC + ED+ S+SL  V +L++K+ +DP  IGRLEVG+ETVIDKSKS+KT LM +F K
Subjt:  KNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK

Query:  HGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYP
        HGNT I+G+D+ NACYGGT+AL N + W+ESS WDGR  +VV  D AVY +GPARPTGGA  +AMLIGP+API FES LRG HM +VYDFYKP++ SEYP
Subjt:  HGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYP

Query:  VVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKIT
         VDGKLS +CY  A+D+ Y +    +EK  GK FS+   D+ +FHSPYNKLVQKSF R+L+NDF  N    ++     L  +  +  +++Y    LEK  
Subjt:  VVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKIT

Query:  QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVPEK
          + K  Y  KV P+TL+ KQ+GN Y  S Y+  +SLL  K   L G RV+ FSYGSG  A+ FS K+ +      +++I   +++  +L  R  + PE 
Subjt:  QQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVPEK

Query:  FVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSL----YRRFYAT
        F E + L E R+  K++  S + + + PG++YL+ VD+     Y R Y+T
Subjt:  FVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSL----YRRFYAT

P54873 Hydroxymethylglutaryl-CoA synthase

8.1e-223

80.94

Show/hide

Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPT VQQEALEAHDGASKGKYTIGLGQDC+AFCTE+EDVISMS   VTSL EKY IDP QIGRLEVGSETVIDKSKSIKTFLMQ+F
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EK GNTD+EGVDSTNACYGGTAAL NCVNWVES+SWDGRYGLV+CTDSAVYAEGPARPTGGAAAIAMLIGPDAPI FESKLR SHM+HVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YK LC+K+EK+EGK+FSI+DADY VFHSPYNKLVQKSFARLL+NDF RNASSIDE AKEK  P+S+L+ DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ++QQ+AKP YDAKVQP+TLIPK+VGNMYTASLYAAF SL+H KH  L+G RV++FSYGSGSTATMFSL++N+ + PFS+SNIA++++V  KLK+RHE  P
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKD--CSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVE M+LMEHRYGAKDF T+K+    LL+PGTYYL EVDSLYRRFY  K       E+G VANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKD--CSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

P54961 Hydroxymethylglutaryl-CoA synthase 1

3.9e-124

Show/hide

Query:  NVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKH
        +VGI+AL++ FP  YV Q  LE +D  S GKYT+GLGQ  M FCT+ ED+ S+ LTVV+ L+E++ I   QIGRLEVG+ET++DKSKS+KT LMQ+F+  
Subjt:  NVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKH

Query:  GNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYPV
         NTDIEGVD+ NACYGGT+ALFN ++WVESSSWDGRY LVV  D AVYA+G ARPTGGA A+AML+G +AP+ F+  +R SHM H YDFYKP+L+S YP 
Subjt:  GNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYPV

Query:  VDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKITQ
        VDGKLS  CYL ALD  Y+  C K +K  G++F I   D  +FH+PY KLVQKS ARL+ NDF R +          L     +  +++Y  R++EK   
Subjt:  VDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKITQ

Query:  QLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHT-SLSGNRVILFSYGSGSTATMFSLKI-NEGQHPFSLSNIAAIL-NVDKKLKSRHELVP
          +K +++ K +PS L+  QVGNMYT SLY   +SLL +K    L+G RV LFSYGSG  ++MFSL+I ++     SL  + + L ++  +L  RH++ P
Subjt:  QLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHT-SLSGNRVILFSYGSGSTATMFSLKI-NEGQHPFSLSNIAAIL-NVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDG
        E+F + M+  EH +    +       +L PGT+YL  VDSLYRR Y    G
Subjt:  EKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATKDG

Q5R7Z9 Hydroxymethylglutaryl-CoA synthase, cytoplasmic

2.1e-122

50.11

Show/hide

Query:  KNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK
        K+VGI+AL+IYFP  YV Q  LE +DG + GKYTIGLGQ  M FCT+ ED+ S+ +TVV +L+E+  +    IGRLEVG+ET+IDKSKS+KT LMQ+FE+
Subjt:  KNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEK

Query:  HGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYP
         GNTDIEG+D+TNACYGGTAA+FN VNW+ESSSWDGRY LVV  D AVYA G ARPTGG  A+A+LIGP+AP+ FE  LRG+HM H YDFYKP++ SEYP
Subjt:  HGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYP

Query:  VVDGKLSQTCYLMALDSSYKQLCHKYE---KLEG--KQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRD
        +VDGKLS  CYL ALD  Y   C K     + EG  K F+++D  + +FHSPY KLVQKS AR+L NDF  + +         L  F  +  +++Y  RD
Subjt:  VVDGKLSQTCYLMALDSSYKQLCHKYE---KLEG--KQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRD

Query:  LEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSN--IAAILNVDKKLKS
        +EK   + +  L+  K + S L+  Q GNMYT+S+Y +  S+L       L+G R+ +FSYGSG  AT++SLK+ +   P S  +   A++ ++  +L S
Subjt:  LEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLL-HNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSN--IAAILNVDKKLKS

Query:  RHELVPEKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATK
        R  + P+ F E M+L E  +   ++        L  GT+YL  VD  +RR YA +
Subjt:  RHELVPEKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDSLYRRFYATK

Arabidopsis top hits

e value

%identity

Alignment

AT4G11820.1 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase

4.4e-192

79.37

Show/hide

Query:  MSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGP
        MS   VTSL EKY IDP QIGRLEVGSETVIDKSKSIKTFLMQ+FEK GNTD+EGVDSTNACYGGTAAL NCVNWVES+SWDGRYGLV+CTDSAVYAEGP
Subjt:  MSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGP

Query:  ARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQ
        ARPTGGAAAIAMLIGPDAPI FESKLR SHM+HVYDFYKPNLASEYPVVDGKLSQTCYLMALDS YK LC+K+EK+EGK+FSI+DADY VFHSPYNKLVQ
Subjt:  ARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQ

Query:  KSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILF
        KSFARLL+NDF RNASSIDE AKEK  P+S+L+ DESYQSRDLEK++QQ+AKP YDAKVQP+TLIPK+VGNMYTASLYAAF SL+H KH  L+G RV++F
Subjt:  KSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILF

Query:  SYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFVEIMQLMEHRYGAKDFATSKD--CSLLSPGTYYLTEVDSLYRRFYATKDGES
        SYGSGSTATMFSL++N+ + PFS+SNIA++++V  KLK+RHE  PEKFVE M+LMEHRYGAKDF T+K+    LL+PGTYYL EVDSLYRRFY  K    
Subjt:  SYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFVEIMQLMEHRYGAKDFATSKD--CSLLSPGTYYLTEVDSLYRRFYATKDGES

Query:  EKIENGVVANGH
           E+G VANGH
Subjt:  EKIENGVVANGH

AT4G11820.2 hydroxymethylglutaryl-CoA synthase / HMG-CoA synthase / 3-hydroxy-3-methylglutaryl coenzyme A synthase

5.8e-224

80.94

Show/hide

Query:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF
        MAKNVGILA+DIYFPPT VQQEALEAHDGASKGKYTIGLGQDC+AFCTE+EDVISMS   VTSL EKY IDP QIGRLEVGSETVIDKSKSIKTFLMQ+F
Subjt:  MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIF

Query:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE
        EK GNTD+EGVDSTNACYGGTAAL NCVNWVES+SWDGRYGLV+CTDSAVYAEGPARPTGGAAAIAMLIGPDAPI FESKLR SHM+HVYDFYKPNLASE
Subjt:  EKHGNTDIEGVDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASE

Query:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK
        YPVVDGKLSQTCYLMALDS YK LC+K+EK+EGK+FSI+DADY VFHSPYNKLVQKSFARLL+NDF RNASSIDE AKEK  P+S+L+ DESYQSRDLEK
Subjt:  YPVVDGKLSQTCYLMALDSSYKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEK

Query:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP
        ++QQ+AKP YDAKVQP+TLIPK+VGNMYTASLYAAF SL+H KH  L+G RV++FSYGSGSTATMFSL++N+ + PFS+SNIA++++V  KLK+RHE  P
Subjt:  ITQQLAKPLYDAKVQPSTLIPKQVGNMYTASLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVP

Query:  EKFVEIMQLMEHRYGAKDFATSKD--CSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH
        EKFVE M+LMEHRYGAKDF T+K+    LL+PGTYYL EVDSLYRRFY  K       E+G VANGH
Subjt:  EKFVEIMQLMEHRYGAKDFATSKD--CSLLSPGTYYLTEVDSLYRRFYATKDGESEKIENGVVANGH

Sequences

Show/hide sequences

CDS sequence

Show/hide CDS sequence

ATGGCTAAGAATGTGGGAATTCTCGCTCTTGATATCTACTTCCCTCCTACCTACGTTCAGCAGGAAGCTTTGGAAGCTCATGATGGAGCAAGCAAGGGGAAATACACTAT
TGGGCTTGGACAGGATTGCATGGCATTCTGTACTGAGGTTGAAGATGTCATCTCAATGAGCTTGACAGTTGTCACTTCCCTTCTTGAGAAGTATGGAATTGACCCAAAAC
AAATTGGCCGGCTGGAAGTAGGCAGTGAGACTGTTATAGATAAAAGCAAATCAATTAAGACTTTCCTGATGCAAATATTTGAGAAGCATGGAAATACCGATATTGAAGGT
GTTGATTCAACTAATGCATGCTATGGGGGTACAGCTGCCCTTTTCAACTGTGTCAACTGGGTAGAGAGCAGCTCCTGGGATGGGCGTTATGGTCTTGTGGTGTGCACAGA
CAGTGCGGTCTATGCGGAAGGACCAGCTCGTCCTACTGGTGGGGCTGCTGCTATTGCCATGCTGATAGGACCTGATGCTCCCATTGCTTTTGAAAGCAAGTTGAGGGGAA
GTCATATGTCTCACGTTTATGATTTCTACAAGCCTAACCTAGCCAGTGAATACCCGGTTGTTGATGGTAAGCTCTCTCAAACTTGTTACCTCATGGCCCTGGATTCTAGT
TACAAACAATTATGTCACAAGTATGAGAAACTGGAGGGCAAACAGTTTTCCATTTCTGATGCTGACTATTTTGTATTTCATTCTCCCTATAACAAGCTTGTGCAGAAGAG
CTTTGCTCGATTGCTCTTTAATGACTTCAAGAGAAATGCCAGCTCAATCGATGAAGTTGCTAAAGAAAAGCTGGCACCATTTTCAACCTTGTCTAACGATGAAAGTTACC
AGAGTCGGGATCTCGAAAAGATAACTCAACAACTTGCAAAGCCTCTTTATGATGCAAAGGTGCAACCCTCTACTTTAATACCAAAGCAAGTTGGAAACATGTATACTGCC
TCTCTCTATGCAGCATTTATTTCACTCCTTCATAACAAGCATACCTCACTGTCAGGAAATAGGGTGATATTGTTCTCTTATGGAAGTGGGTCAACTGCAACAATGTTCTC
ATTGAAAATCAATGAAGGTCAACATCCCTTTAGTTTATCCAACATCGCAGCTATCTTGAATGTGGATAAGAAGTTGAAATCGAGGCACGAGTTGGTACCCGAGAAATTTG
TCGAAATAATGCAGCTGATGGAGCATCGGTATGGGGCCAAGGACTTCGCGACGAGCAAGGACTGCAGCCTCCTATCACCAGGCACCTACTATCTCACTGAAGTCGATTCA
TTGTACAGGAGATTCTACGCTACGAAGGATGGCGAAAGCGAAAAGATTGAGAATGGTGTGGTTGCCAATGGTCACTGA

mRNA sequence

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CCCATGTGAGCCTCACCATCTTTCTCTGCTACTTTCAAGGATTTCCTCTCTCCTCTCTCAATTTTCTTCTCTCTATTTCGTCATTTTCACAGAAAAACGAGATACAGAAG
GAGAGCTTCGTAGCATACTTTGGTTCTTTATTGCTTTGGATCGGTTTAATTTGAATTGAGCGCAAAAAACTGGTTCTGGAAATGGCTAAGAATGTGGGAATTCTCGCTCT
TGATATCTACTTCCCTCCTACCTACGTTCAGCAGGAAGCTTTGGAAGCTCATGATGGAGCAAGCAAGGGGAAATACACTATTGGGCTTGGACAGGATTGCATGGCATTCT
GTACTGAGGTTGAAGATGTCATCTCAATGAGCTTGACAGTTGTCACTTCCCTTCTTGAGAAGTATGGAATTGACCCAAAACAAATTGGCCGGCTGGAAGTAGGCAGTGAG
ACTGTTATAGATAAAAGCAAATCAATTAAGACTTTCCTGATGCAAATATTTGAGAAGCATGGAAATACCGATATTGAAGGTGTTGATTCAACTAATGCATGCTATGGGGG
TACAGCTGCCCTTTTCAACTGTGTCAACTGGGTAGAGAGCAGCTCCTGGGATGGGCGTTATGGTCTTGTGGTGTGCACAGACAGTGCGGTCTATGCGGAAGGACCAGCTC
GTCCTACTGGTGGGGCTGCTGCTATTGCCATGCTGATAGGACCTGATGCTCCCATTGCTTTTGAAAGCAAGTTGAGGGGAAGTCATATGTCTCACGTTTATGATTTCTAC
AAGCCTAACCTAGCCAGTGAATACCCGGTTGTTGATGGTAAGCTCTCTCAAACTTGTTACCTCATGGCCCTGGATTCTAGTTACAAACAATTATGTCACAAGTATGAGAA
ACTGGAGGGCAAACAGTTTTCCATTTCTGATGCTGACTATTTTGTATTTCATTCTCCCTATAACAAGCTTGTGCAGAAGAGCTTTGCTCGATTGCTCTTTAATGACTTCA
AGAGAAATGCCAGCTCAATCGATGAAGTTGCTAAAGAAAAGCTGGCACCATTTTCAACCTTGTCTAACGATGAAAGTTACCAGAGTCGGGATCTCGAAAAGATAACTCAA
CAACTTGCAAAGCCTCTTTATGATGCAAAGGTGCAACCCTCTACTTTAATACCAAAGCAAGTTGGAAACATGTATACTGCCTCTCTCTATGCAGCATTTATTTCACTCCT
TCATAACAAGCATACCTCACTGTCAGGAAATAGGGTGATATTGTTCTCTTATGGAAGTGGGTCAACTGCAACAATGTTCTCATTGAAAATCAATGAAGGTCAACATCCCT
TTAGTTTATCCAACATCGCAGCTATCTTGAATGTGGATAAGAAGTTGAAATCGAGGCACGAGTTGGTACCCGAGAAATTTGTCGAAATAATGCAGCTGATGGAGCATCGG
TATGGGGCCAAGGACTTCGCGACGAGCAAGGACTGCAGCCTCCTATCACCAGGCACCTACTATCTCACTGAAGTCGATTCATTGTACAGGAGATTCTACGCTACGAAGGA
TGGCGAAAGCGAAAAGATTGAGAATGGTGTGGTTGCCAATGGTCACTGAAATAAAAATGACAACAAACAAGGAGTGTAGCCAAAGCTTCTGTTCATCCAAATATTGTCAG
TGTCAACAAGAATTTTTCTTCTCACAAGTTATTTGCAAGCTAAGCTATAGAAGGCAGTATGTTCACAGCGGGTAGTTTTCTGTTGTTCTTTCTCTCCCTCTCTCTCTTTT
TTTTCTTTTTTTCTTTTTTTTTTTTTCATTTCTCCCTGTTAGAAAAATTGTCTCAATAATCGGTTGGCTTTATGTAATGTTGTTGATGATGATGATGATAATGTAGACTC
CTCTCCATTTTCCACTTTCTATTGGTAATTATCATCAAATTTGTTTGTTGATTCTTCAAATTCCCAAATTAATGGAGAACTGAGCAATATTGTTGAAAGAAAAAGACAAA
TGGCCCCTTTGGATCAAAGAATATATTGACTATCTAAAAATATAATATTTAGAATTTTACCATTTTAACCTTCCATTAATTTTGAATCCCAACCATGATCTCTCAC

Protein sequence

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MAKNVGILALDIYFPPTYVQQEALEAHDGASKGKYTIGLGQDCMAFCTEVEDVISMSLTVVTSLLEKYGIDPKQIGRLEVGSETVIDKSKSIKTFLMQIFEKHGNTDIEG
VDSTNACYGGTAALFNCVNWVESSSWDGRYGLVVCTDSAVYAEGPARPTGGAAAIAMLIGPDAPIAFESKLRGSHMSHVYDFYKPNLASEYPVVDGKLSQTCYLMALDSS
YKQLCHKYEKLEGKQFSISDADYFVFHSPYNKLVQKSFARLLFNDFKRNASSIDEVAKEKLAPFSTLSNDESYQSRDLEKITQQLAKPLYDAKVQPSTLIPKQVGNMYTA
SLYAAFISLLHNKHTSLSGNRVILFSYGSGSTATMFSLKINEGQHPFSLSNIAAILNVDKKLKSRHELVPEKFVEIMQLMEHRYGAKDFATSKDCSLLSPGTYYLTEVDS
LYRRFYATKDGESEKIENGVVANGH

Tan0005321 (gene) of Snake gourd v1 genome