; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; CuGenDBv2

Tan0017216 (gene) of Snake gourd v1 genome

Gene IDTan0017216
OrganismTrichosanthes anguina (Snake gourd v1)
DescriptionHNH domain-containing protein
Genome locationLG09:71470738..71474120
RNA-Seq ExpressionTan0017216
SyntenyTan0017216
Gene Ontology termsGO:0090305 - nucleic acid phosphodiester bond hydrolysis (biological process)
GO:0016021 - integral component of membrane (cellular component)
GO:0003676 - nucleic acid binding (molecular function)
GO:0004519 - endonuclease activity (molecular function)
InterPro domainsIPR003615 - HNH nuclease


Homology Show/hide homology
GenBank top hitse value%identityAlignment
KAG6587544.1 hypothetical protein SDJN03_16109, partial [Cucurbita argyrosperma subsp. sororia]4.6e-8484.46Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRTS S RFESRR+GS  SRLSP+TSLLDRDLVT EANLLGDLKLS D  VSDYNPRSFP +VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTE+SRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

XP_008453210.1 PREDICTED: uncharacterized protein LOC103493997 [Cucumis melo]1.9e-8282.38Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRT A T  ES RYGS PS LSP+ SLLDRDLVTGE+NLLGDLK S +D VS+YNPRSFP++VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

XP_022933556.1 uncharacterized protein LOC111440950 [Cucurbita moschata]7.1e-8584.97Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRTS S RFESRR+GS  SRLSP+TSLLDRDLVT EANLLGDLKLS DD VSDYNPRSFP +VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTE+SRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

XP_022972967.1 uncharacterized protein LOC111471489 [Cucurbita maxima]1.4e-8585.49Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRTS STRFESRR+GS  SRLSP+TSLLDRDLVT EANLLGDLKLS DD VSDYNPRSFP +VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTE+SRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

XP_023529236.1 uncharacterized protein LOC111792136 [Cucurbita pepo subsp. pepo]9.3e-8584.97Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRTS STRFESRR+GS  SRLSP+TSLLDRDLVT EANLLGDLKLS D  VSDYNPRSFP +VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTE+SRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

TrEMBL top hitse value%identityAlignment
A0A0A0LUI5 HNH domain-containing protein2.7e-8281.87Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRT + T  ESR YGS PS LSP+ SLLDRDLVTGE++LLGDLK S DD VS+YNPRSFP++VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

A0A1S3BWU4 uncharacterized protein LOC1034939979.4e-8382.38Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRT A T  ES RYGS PS LSP+ SLLDRDLVTGE+NLLGDLK S +D VS+YNPRSFP++VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

A0A5A7US43 HNH endonuclease9.4e-8382.38Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRT A T  ES RYGS PS LSP+ SLLDRDLVTGE+NLLGDLK S +D VS+YNPRSFP++VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

A0A6J1EZE0 uncharacterized protein LOC1114409503.4e-8584.97Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRTS S RFESRR+GS  SRLSP+TSLLDRDLVT EANLLGDLKLS DD VSDYNPRSFP +VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTE+SRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

A0A6J1I688 uncharacterized protein LOC1114714896.9e-8685.49Show/hide
Query:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW
        MR  KESKKKTRPSSPLRDRTS STRFESRR+GS  SRLSP+TSLLDRDLVT EANLLGDLKLS DD VSDYNPRSFP +VKQQCWDKAEKIKGRDPDRW
Subjt:  MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRW

Query:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD
        RRDALGN VFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTE+SRAELIQKSSYCRVSG  + LL  +    +H G D
Subjt:  RRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG-TLALLNCNRLWYLHLGSD

SwissProt top hitse value%identityAlignment
No hits found
Arabidopsis top hitse value%identityAlignment
AT1G18680.1 HNH endonuclease domain-containing protein5.7e-2448.04Show/hide
Query:  PRSFPNTVKQQCWDKAEKIKGRDPDRWRRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVS
        PR F    K +CW  A+ + GR P+RWR+D  GNIV ++   C GCLC +YDHI+PYSKGG+S  ENCQ+LQ  VNR K  +  +    L  KS  C + 
Subjt:  PRSFPNTVKQQCWDKAEKIKGRDPDRWRRDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVS

Query:  GT
         T
Subjt:  GT

AT3G47490.1 HNH endonuclease1.4e-5160.12Show/hide
Query:  PGKESKKKTRPSSPLRDRTSASTRFESRRYG-SQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWR
        P +   +    SSP + R   S+   +R  G ++  ++  + +LLDR+    E  L         +P     PRSFP +VKQQCW+KAEKIKGRDP+RWR
Subjt:  PGKESKKKTRPSSPLRDRTSASTRFESRRYG-SQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWR

Query:  RDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG
        RD LGNIVFRKLVGCPGCLCHDYDHI+PYSKGGKSTLENCQVLQA VNRSKGN+T+ISR+ELIQ+SSYCRV+G
Subjt:  RDALGNIVFRKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG

AT3G47490.2 HNH endonuclease9.1e-3051.91Show/hide
Query:  PGKESKKKTRPSSPLRDRTSASTRFESRRYG-SQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWR
        P +   +    SSP + R   S+   +R  G ++  ++  + +LLDR+    E  L         +P     PRSFP +VKQQCW+KAEKIKGRDP+RWR
Subjt:  PGKESKKKTRPSSPLRDRTSASTRFESRRYG-SQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWR

Query:  RDALGNIVFRKLVGCPGCLCHDYDHILPYSK
        RD LGNIVFRKLVGCPGCLCHDYDHI+PYSK
Subjt:  RDALGNIVFRKLVGCPGCLCHDYDHILPYSK

AT3G47490.3 HNH endonuclease5.7e-4853.89Show/hide
Query:  PGKESKKKTRPSSPLRDRTSASTRFESRRYG-SQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWR
        P +   +    SSP + R   S+   +R  G ++  ++  + +LLDR+    E  L         +P     PRSFP +VKQQCW+KAEKIKGRDP+RWR
Subjt:  PGKESKKKTRPSSPLRDRTSASTRFESRRYG-SQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWR

Query:  RDALGNIVFRKLVGCPGCLCHDYDHILPYS--------------------KGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG
        RD LGNIVFRKLVGCPGCLCHDYDHI+PYS                    KGGKSTLENCQVLQA VNRSKGN+T+ISR+ELIQ+SSYCRV+G
Subjt:  RDALGNIVFRKLVGCPGCLCHDYDHILPYS--------------------KGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSG


Sequences Show/hide sequences
CDS sequenceShow/hide CDS sequence
ATGAGGCCTGGCAAAGAATCGAAGAAGAAAACTCGGCCCTCATCACCGCTCAGGGACCGTACCAGTGCTTCAACAAGGTTCGAGTCGAGGCGTTATGGGTCTCAACCATC
AAGGCTCAGCCCCACTACTTCCCTTCTGGACCGTGACCTCGTAACCGGCGAAGCCAATCTCCTCGGAGACCTAAAACTCTCCTCTGACGACCCAGTTTCAGACTACAATC
CCCGGAGCTTTCCTAACACTGTGAAGCAGCAATGTTGGGATAAGGCCGAGAAGATTAAAGGAAGGGACCCAGATCGGTGGCGCCGAGATGCTCTGGGTAACATCGTTTTT
CGAAAGCTTGTTGGCTGCCCTGGTTGTCTTTGTCATGACTATGATCACATTTTGCCTTACTCTAAGGGTGGAAAAAGCACACTGGAAAATTGTCAGGTTTTGCAGGCAAC
TGTTAATCGATCAAAGGGAAACCGTACTGAAATTTCAAGAGCAGAACTAATACAGAAAAGCTCTTACTGCCGGGTCTCAGGTACACTAGCTTTATTAAACTGCAATAGAT
TATGGTATTTACACCTTGGTAGTGATATTATATGGCCAGCCCGTTTAAATAATTTACAGGTCGAGACATGGATCTTCTTGAACTGTCTGCTTATGGCAATGTACATCGTG
GACAAGACTCAGGAGGGTGTAGAATTCAGTGACTCATTGAGTGATTATATCATAACCTGTAGTGGAATTGATTCCAGTGTGAGGCGTGATAACTTAACAAAAAAAGATTG
A
mRNA sequenceShow/hide mRNA sequence
GGCCACTTTGCATTTATTACCGCTCAAATTATCTCATCAACGAGCGAAAGATGAGGCCTGGCAAAGAATCGAAGAAGAAAACTCGGCCCTCATCACCGCTCAGGGACCGT
ACCAGTGCTTCAACAAGGTTCGAGTCGAGGCGTTATGGGTCTCAACCATCAAGGCTCAGCCCCACTACTTCCCTTCTGGACCGTGACCTCGTAACCGGCGAAGCCAATCT
CCTCGGAGACCTAAAACTCTCCTCTGACGACCCAGTTTCAGACTACAATCCCCGGAGCTTTCCTAACACTGTGAAGCAGCAATGTTGGGATAAGGCCGAGAAGATTAAAG
GAAGGGACCCAGATCGGTGGCGCCGAGATGCTCTGGGTAACATCGTTTTTCGAAAGCTTGTTGGCTGCCCTGGTTGTCTTTGTCATGACTATGATCACATTTTGCCTTAC
TCTAAGGGTGGAAAAAGCACACTGGAAAATTGTCAGGTTTTGCAGGCAACTGTTAATCGATCAAAGGGAAACCGTACTGAAATTTCAAGAGCAGAACTAATACAGAAAAG
CTCTTACTGCCGGGTCTCAGGTACACTAGCTTTATTAAACTGCAATAGATTATGGTATTTACACCTTGGTAGTGATATTATATGGCCAGCCCGTTTAAATAATTTACAGG
TCGAGACATGGATCTTCTTGAACTGTCTGCTTATGGCAATGTACATCGTGGACAAGACTCAGGAGGGTGTAGAATTCAGTGACTCATTGAGTGATTATATCATAACCTGT
AGTGGAATTGATTCCAGTGTGAGGCGTGATAACTTAACAAAAAAAGATTGAAATGAAAAAAATCCTATTGTTGAAGGGTTAGGAGTTCAAAAGCAACAAGTTCATTATAT
GGGAAATGAAAGAAGTGAAAGAAAAAGCATATAATGGGAAGTGTATGCGCAAGTTGTGAATACATTTGTAAAGTTAAAATTCTTAGCAATCCCACTCTATCAGGCAGGAA
AGTAAATGGATGTTCCTTTCTTCTTTTTCTTTGCGTTATGGGGAAGTGATGCTTCACACTCGCACTTCTTTCTTGTGGATGTTTTTTCAAACAAAAGAATTTTCACCAAC
TTTTGTTCAATCAAATGCG
Protein sequenceShow/hide protein sequence
MRPGKESKKKTRPSSPLRDRTSASTRFESRRYGSQPSRLSPTTSLLDRDLVTGEANLLGDLKLSSDDPVSDYNPRSFPNTVKQQCWDKAEKIKGRDPDRWRRDALGNIVF
RKLVGCPGCLCHDYDHILPYSKGGKSTLENCQVLQATVNRSKGNRTEISRAELIQKSSYCRVSGTLALLNCNRLWYLHLGSDIIWPARLNNLQVETWIFLNCLLMAMYIV
DKTQEGVEFSDSLSDYIITCSGIDSSVRRDNLTKKD